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  • Official Full Name
  • anaplastic lymphoma receptor tyrosine kinase
  • Background
  • This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
  • Synonyms
  • Alk; ALK tyrosine kinase receptor; ALK Tyrosine Kinase Receptor Precursor; ALK/EML4 fusion gene, included; ALK/NPM1 fusion gene, included; ALK_HUMAN; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; CD246; CD246 Antigen; EC 2.7.10.1; Ki 1; Ki1; NBLST3; Tcrz; TFG/ALK
Cat.#:Alk-15MTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Alk Protein
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Cat.#:ALK-16MTag:
Source (Host):HEK293Species:Macaca nemestrina
Product nameRecombinant Macaca nemestrina ALK Protein
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Cat.#:ALK-26499THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALK
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Cat.#:ALK-01HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALK (aa1060-1620), His-tagged
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Cat.#:ALK-08HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALK, GST-tagged
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Cat.#:ALK-09HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALK, MYC/DDK-tagged
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Cat.#:ALK-10HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK, His-tagged
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Cat.#:ALK-12HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK, GST-tagged
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Cat.#:ALK-13HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (F1174S), GST-tagged
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Cat.#:ALK-14HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (L1196M), GST-tagged
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Cat.#:ALK-15HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (S1206R), GST-tagged
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Cat.#:ALK-27HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (T1151_L1152insT), GST-tagged
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Cat.#:ALK-28HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (F1174L), GST-tagged
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Cat.#:ALK-29HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (G1202R), GST-tagged
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Cat.#:ALK-30HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (G1269S), GST-tagged
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Cat.#:ALK-31HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (R1275Q), GST-tagged
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Cat.#:ALK-32HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ALK protein, Flag-tagged, Biotinylated
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Cat.#:ALK-33HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ALK(L1196M) protein, Flag-tagged, Biotinylated
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Cat.#:ALK-385HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ALK Protein, DDK/His-tagged
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Cat.#:ALK-469HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ALK Protein, GST-tagged
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Cat.#:ALK-471HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ALK Protein, GST-His tagged
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Cat.#:ALK-473HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALK Protein, GST-tagged
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Cat.#:ALK-49HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (T1151M), GST-tagged
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Cat.#:ALK-50HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (L1152R), GST-tagged
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Cat.#:ALK-51HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (G1269A), GST-tagged
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Cat.#:ALK-58HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (C1156Y), GST-tagged
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Cat.#:ALK-65HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Anaplastic Lymphoma Receptor Tyrosine Kinase
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Cat.#:ALK-89HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALK, His Tag
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Cat.#:ALK-92HTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALK, GST-His Tag
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Cat.#:ALK-1552MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALK Protein
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Cat.#:Alk-3270MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Alk, His-tagged
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Cat.#:ALK-1625RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ALK Protein
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Cat.#:ALK-1626RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ALK Protein, hIgG1-tagged
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Cat.#:ALK-1627RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ALK Protein, hIgG4-tagged
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Involved Pathway

ALK involved in several pathways and played different roles in them. We selected most pathways ALK participated on our site, such as Non-small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Non-small cell lung cancer
KRAS; RXRB; FHIT; STK4; SOS1; GRB2; TRP53; ALK; TGFA; ARAF

Protein Function

ALK has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALK itself. We selected most functions ALK had, and list some proteins which have the same functions with ALK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein IARS; CHD9; XRCC6; PIP5KL1; NME4; PAK2B; ZNF143B; IGF1RA; Aatk; HSPD1
Function NF-kappaB-inducing kinase activity
Related Protein MAP3K14; IRAK1; RIPK3; PPP4C; ALPK2; IKBKE; ALK
Function identical protein binding
Related Protein ATG16L1; SH3GL3; HGF; DAPK1; PLIN5; PRKD1; HAND2; DHX8; NOD1; FTL
Function protein binding
Related Protein TMEM182; ALOX5AP; ARL2; DCPS; USP36; PIANP; SEPT7; FKBP7; HTR1A; DOCK9
Function protein tyrosine kinase activity
Related Protein JAK2A; MET; EPHA2A; BMX; BTK; PDGFRB; MAP3K11; CSF1RA; NTRK2B; JAK2
Function transmembrane receptor protein tyrosine kinase activity
Related Protein MERTK; FGFR1A; IGF1RB; EGFRA; EPHB2B; EK1; EPHB4; AXL; KITB; INSRB

Interacting Protein

ALK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALK here. Most of them are supplied by our site. Hope this information will be useful for your research of ALK.
crizotinib; ch5424802; PTPRZ1; HSP90AB1; EPHA1; EIF4B

ALK Related Articles

Ziegler, JU; Schweiggert, RM; et al. A method for the simultaneous extraction and quantitation of lipophilic antioxidants in Triticum sp by HPLC-DAD/FLD-MSn. JOURNAL OF FOOD COMPOSITION AND ANALYSIS 39:94-102(2015).
Ishibashi, Y; Miyoshi, H; et al. Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis. ONCOLOGY REPORTS 33:1667-1674(2015).