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ALOX15B

  • Official Full Name

    arachidonate 15-lipoxygenase, type B

  • Overview

    This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms

    ALOX15B; arachidonate 15-lipoxygenase, type B; arachidonate 15 lipoxygenase, second type; arachidonate 15-lipoxygenase B; 15 LOX 2; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenase 2; arachidonate omega(6) lipoxygenase; arachidonate 15-lipoxygenas;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • Fc|His
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALOX15B-408H Recombinant Human ALOX15B, Gly & Pro tagged Insect Cell Fc/His
Human ALOX15B-486H Recombinant Human ALOX15B Protein, GST-tagged Wheat Germ GST
Human ALOX15B-488H Recombinant Human ALOX15B, His-GST tagged Insect Cell Fc
Human ALOX15B-580H Recombinant Human Arachidonate 15-lipoxygenase, Type B, His-tagged E.coli His
Human ALOX15B-6849H Recombinant Human ALOX15B protein, His & T7-tagged E.coli His/T7 Arg253~Glu490 (Accession # O15296)
Human ALOX15B-001HCL Recombinant Human ALOX15B cell lysate Insect Cell N/A
Human ALOX15B-002HCL Recombinant Human ALOX15B cell lysate Insect Cell N/A
Human ALOX15B-054H Recombinant Human ALOX15B Protein, His-tagged E. coli His
Human ALOX15B-1316H Recombinant Human ALOX15B protein(Met1-Ile676), His&GST-tagged Insect Cells N-His&GST Met1-Ile676
Human ALOX15B-40H Recombinant Human ALOX15B Protein, His-tagged E.coli His
Human ALOX15B-1480HF Recombinant Full Length Human ALOX15B Protein, GST-tagged In Vitro Cell Free System GST 676 amino acids
Human ALOX15B-0521H Recombinant Human ALOX15B Protein (Arg253-Glu490), N-His-tagged E.coli N-His Arg253-Glu490
Human ALOX15B-3241H Recombinant Human ALOX15B protein(Met1-Ile676) Insect Cells N/A Met1-Ile676
Human ALOX15B-26021TH Recombinant Human ALOX15B Wheat Germ N/A 100 amino acids
Rat Alox15b-6850R Recombinant Rat Alox15b protein, His & T7-tagged E.coli His/T7 Asp349~Val633 (Accession # Q8K4F2)
Rat ALOX15B-637R Recombinant Rat ALOX15B Protein Mammalian Cell His
Rat ALOX15B-293R-B Recombinant Rat ALOX15B Protein Pre-coupled Magnetic Beads HEK293
Rat ALOX15B-293R Recombinant Rat ALOX15B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ALOX15B involved in several pathways and played different roles in them. We selected most pathways ALOX15B participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX15B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCYP1A2;ALOX12E;CYP2J5;CYP2U1;PLA2G4C;LTA4H;CYP2N13;CYP2C8;ALOX5B.3
Metabolic pathwaysCYP2P6;B3GAT3;LASS4;GBA2;PYCR1A;UQCRH;BCMO1;SPRA;CYP2C45
Serotonergic synapsePLA2G4A;GNG4;HRAS;GNB4;ALOX12;PLCB1;MAOA;HTR2B;CYP2C54

ALOX15B has several biochemical functions, for example, arachidonate 15-lipoxygenase activity, arachidonate 8(S)-lipoxygenase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX15B itself. We selected most functions ALOX15B had, and list some proteins which have the same functions with ALOX15B. You can find most of the proteins on our site.

Function Related Protein
arachidonate 15-lipoxygenase activityALOX15;ALOX8;ALOX15B
arachidonate 8(S)-lipoxygenase activityALOX15B;ALOX8
calcium ion bindingPCDH2AC;TBC1D9;PLCD1B;FAT1A;TPM4;GNPTAB;STIM1;PCDHGA11;CIB4
iron ion bindingCYP7B1;CYP2P10;CYP26A1;CYP2C70;FDX1;NOS1;CYP2A13;CYP2AD6;HBAD
linoleate 13S-lipoxygenase activityALOX15B;ALOX8;ALOX12
lipid bindingBPIFA5;DOK7;STARD8;PCYT1A;PFN4;BPIFB3;APOA4A;ACOT11A;TRIP10A

ALOX15B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX15B here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX15B.

  • Q&As
  • Reviews

Q&As (13)

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Does ALOX15B mutation cause autoimmune diseases? 04/18/2023

Yes, certain ALOX15B gene mutations are closely associated with the onset of several autoimmune diseases.

What is the relationship between the expression level of ALOX15B in tumors and patient prognosis? 11/25/2022

The expression level of ALOX15B in tumors is closely related to the treatment response and prognosis of patients.

What is the relationship between ALOX15B and diseases related to blood circulation system? 02/25/2022

Whether ALOX15B is related to the occurrence of diseases related to the blood circulation system (such as heart disease, thrombosis, etc.) still needs further research.

What diseases will be caused if the ALOX15B gene is mutated? 08/20/2021

Mutations in ALOX15B can lead to a variety of diseases, such as asthma and autoimmune diseases.

Does ALOX15B have application prospects in the treatment of skin diseases? 04/08/2021

Yes, ALOX15B may be a target for the treatment of certain skin diseases.

How does the expression level of ALOX15B in patients with asthma correlate with the severity of the disease? 01/24/2021

Studies have shown that the level of ALOX15B expression in asthma patients is positively correlated with the severity of the disease.

Does ALOX15B participate in the systemic inflammatory response of asthma? 10/27/2020

Yes, ALOX15B can promote an increased systemic inflammatory response in patients with asthma.

Does ALOX15B have potential application value in the treatment of tumors? 10/07/2020

Yes, some studies suggest that ALOX15B has the potential to be a new target for tumor therapy.

Is ALOX15B involved in tumor growth and development? 07/12/2020

Yes, ALOX15B is associated with the occurrence, development and metastasis of various cancers.

What is the role of ALOX15B in the human body? 04/25/2020

The enzyme encoded by ALOX15B is mainly involved in the metabolism of arachidonic acid (AA), which is closely related to biological processes such as inflammation and immune regulation.

What is the relationship between ALOX15B and asthma? 04/24/2020

Many experimental studies have shown that ALOX15B is closely related to the pathogenesis and pathophysiological mechanism of asthma.

What is the role of ALOX15B in angiogenesis? 03/22/2020

ALOX15B can inhibit angiogenesis and thus play a role in tumor growth and metastasis.

Is ALOX15B involved in the onset and progression of skin diseases? 06/30/2019

Yes, ALOX15B is closely related to the onset and progression of many skin diseases (such as psoriasis, psoriasis, etc.).

Customer Reviews (4)

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Reviews
05/22/2022

    By using this recombinant protein, the efficiency of my experiments was significantly improved, and unnecessary waste of time was also reduced.

    06/21/2021

      I appreciate the attention paid to product quality by this recombinant protein manufacturer, and their recombinant proteins are very stable, which makes our experiments smoother.

      03/06/2020

        The catalytic activity of this protein is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.

        09/22/2019

          The reproducibility of the Western blot was significantly improved using this recombinant protein.

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