ALOX15B
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Official Full Name
arachidonate 15-lipoxygenase, type B
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Overview
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
ALOX15B; arachidonate 15-lipoxygenase, type B; arachidonate 15 lipoxygenase, second type; arachidonate 15-lipoxygenase B; 15 LOX 2; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenase 2; arachidonate omega(6) lipoxygenase; arachidonate 15-lipoxygenas;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Wheat Germ
- Fc
- Fc|His
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ALOX15B-408H | Recombinant Human ALOX15B, Gly & Pro tagged | Insect Cell | Fc/His | ||
Human | ALOX15B-486H | Recombinant Human ALOX15B Protein, GST-tagged | Wheat Germ | GST | ||
Human | ALOX15B-488H | Recombinant Human ALOX15B, His-GST tagged | Insect Cell | Fc | ||
Human | ALOX15B-580H | Recombinant Human Arachidonate 15-lipoxygenase, Type B, His-tagged | E.coli | His | ||
Human | ALOX15B-6849H | Recombinant Human ALOX15B protein, His & T7-tagged | E.coli | His/T7 | Arg253~Glu490 (Accession # O15296) | |
Human | ALOX15B-001HCL | Recombinant Human ALOX15B cell lysate | Insect Cell | N/A | ||
Human | ALOX15B-002HCL | Recombinant Human ALOX15B cell lysate | Insect Cell | N/A | ||
Human | ALOX15B-054H | Recombinant Human ALOX15B Protein, His-tagged | E. coli | His | ||
Human | ALOX15B-1316H | Recombinant Human ALOX15B protein(Met1-Ile676), His&GST-tagged | Insect Cells | N-His&GST | Met1-Ile676 | |
Human | ALOX15B-40H | Recombinant Human ALOX15B Protein, His-tagged | E.coli | His | ||
Human | ALOX15B-1480HF | Recombinant Full Length Human ALOX15B Protein, GST-tagged | In Vitro Cell Free System | GST | 676 amino acids | |
Human | ALOX15B-0521H | Recombinant Human ALOX15B Protein (Arg253-Glu490), N-His-tagged | E.coli | N-His | Arg253-Glu490 | |
Human | ALOX15B-3241H | Recombinant Human ALOX15B protein(Met1-Ile676) | Insect Cells | N/A | Met1-Ile676 | |
Human | ALOX15B-26021TH | Recombinant Human ALOX15B | Wheat Germ | N/A | 100 amino acids | |
Rat | Alox15b-6850R | Recombinant Rat Alox15b protein, His & T7-tagged | E.coli | His/T7 | Asp349~Val633 (Accession # Q8K4F2) | |
Rat | ALOX15B-637R | Recombinant Rat ALOX15B Protein | Mammalian Cell | His | ||
Rat | ALOX15B-293R-B | Recombinant Rat ALOX15B Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ALOX15B-293R | Recombinant Rat ALOX15B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
ALOX15B involved in several pathways and played different roles in them. We selected most pathways ALOX15B participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX15B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arachidonic acid metabolism | CYP1A2;ALOX12E;CYP2J5;CYP2U1;PLA2G4C;LTA4H;CYP2N13;CYP2C8;ALOX5B.3 |
Metabolic pathways | CYP2P6;B3GAT3;LASS4;GBA2;PYCR1A;UQCRH;BCMO1;SPRA;CYP2C45 |
Serotonergic synapse | PLA2G4A;GNG4;HRAS;GNB4;ALOX12;PLCB1;MAOA;HTR2B;CYP2C54 |
ALOX15B has several biochemical functions, for example, arachidonate 15-lipoxygenase activity, arachidonate 8(S)-lipoxygenase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX15B itself. We selected most functions ALOX15B had, and list some proteins which have the same functions with ALOX15B. You can find most of the proteins on our site.
Function | Related Protein |
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arachidonate 15-lipoxygenase activity | ALOX15;ALOX8;ALOX15B |
arachidonate 8(S)-lipoxygenase activity | ALOX15B;ALOX8 |
calcium ion binding | PCDH2AC;TBC1D9;PLCD1B;FAT1A;TPM4;GNPTAB;STIM1;PCDHGA11;CIB4 |
iron ion binding | CYP7B1;CYP2P10;CYP26A1;CYP2C70;FDX1;NOS1;CYP2A13;CYP2AD6;HBAD |
linoleate 13S-lipoxygenase activity | ALOX15B;ALOX8;ALOX12 |
lipid binding | BPIFA5;DOK7;STARD8;PCYT1A;PFN4;BPIFB3;APOA4A;ACOT11A;TRIP10A |
ALOX15B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX15B here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX15B.
- Q&As
- Reviews
Q&As (13)
Ask a questionYes, certain ALOX15B gene mutations are closely associated with the onset of several autoimmune diseases.
The expression level of ALOX15B in tumors is closely related to the treatment response and prognosis of patients.
Whether ALOX15B is related to the occurrence of diseases related to the blood circulation system (such as heart disease, thrombosis, etc.) still needs further research.
Mutations in ALOX15B can lead to a variety of diseases, such as asthma and autoimmune diseases.
Yes, ALOX15B may be a target for the treatment of certain skin diseases.
Studies have shown that the level of ALOX15B expression in asthma patients is positively correlated with the severity of the disease.
Yes, ALOX15B can promote an increased systemic inflammatory response in patients with asthma.
Yes, some studies suggest that ALOX15B has the potential to be a new target for tumor therapy.
Yes, ALOX15B is associated with the occurrence, development and metastasis of various cancers.
The enzyme encoded by ALOX15B is mainly involved in the metabolism of arachidonic acid (AA), which is closely related to biological processes such as inflammation and immune regulation.
Many experimental studies have shown that ALOX15B is closely related to the pathogenesis and pathophysiological mechanism of asthma.
ALOX15B can inhibit angiogenesis and thus play a role in tumor growth and metastasis.
Yes, ALOX15B is closely related to the onset and progression of many skin diseases (such as psoriasis, psoriasis, etc.).
Customer Reviews (4)
Write a reviewBy using this recombinant protein, the efficiency of my experiments was significantly improved, and unnecessary waste of time was also reduced.
I appreciate the attention paid to product quality by this recombinant protein manufacturer, and their recombinant proteins are very stable, which makes our experiments smoother.
The catalytic activity of this protein is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.
The reproducibility of the Western blot was significantly improved using this recombinant protein.
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