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AMBP

  • Official Full Name

    alpha-1-microglobulin/bikunin precursor

  • Overview

    This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes.
  • Synonyms

    AMBP; alpha-1-microglobulin/bikunin precursor; A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Urine
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • P.pastoris
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • mFc
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AMBP-230H Active Recombinant Human AMBP P.pastoris N/A
Human AMBP-493H Recombinant Human AMBP protein, mFc-tagged HEK293 mFc Met1-Val203
Human AMBP-220H Recombinant Human AMBP, His-tagged Human Cell His Met1-Val203
Human AMBP-222H Recombinant Human AMBP Protein, His-tagged E.coli His Val22~Val203
Human AMBP-6894H Recombinant Human Alpha-1-Microglobulin/Bikunin Precursor, His-tagged E.coli His 20-203aa
Human AMBP-494H Active Recombinant Human AMBP protein, His-tagged Yeast His Ala206-Leu348
Human AMBP-515H Recombinant Human AMBP protein, GST-tagged Wheat Germ GST
Human AMBP-001HCL Recombinant Human AMBP cell lysate Human Cell N/A
Human AMBP-127H Recombinant Human AMBP Protein, His-tagged HEK293F N-His Gly20-Asn352
Human AMBP-5H Active Human alpha 1-Microglobulin Reference Standard N/A
Human AMBP-5312H Native Human Alpha-1-Microglobulin/Bikunin Precursor Human Urine N/A
Human AMBP-27H Native Human AMBP N/A
Human AMBP-128H Recombinant Human AMBP Protein, His-tagged HEK293F N-His Gly20-Arg202
Human AMBP-1942H Recombinant Human AMBP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AMBP-882HFL Recombinant Full Length Human AMBP Protein, C-Flag-tagged Mammalian cells Flag
Human AMBP-1024HF Recombinant Full Length Human AMBP Protein, GST-tagged In Vitro Cell Free System GST 352 amino acids
Human AMBP-331H Recombinant Human AMBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AMBP-0308H Recombinant Human AMBP Protein (Val22-Val203), His-tagged E.coli His Val22-Val203
Human AMBP-331H-B Recombinant Human AMBP Protein Pre-coupled Magnetic Beads HEK293
Mouse AMBP-1589M Recombinant Mouse AMBP Protein Mammalian Cell His
Mouse Ambp-223M Recombinant Mouse Ambp Protein, His-tagged E.coli His Arg18~Ala202
Mouse Ambp-224M Recombinant Mouse Ambp Protein, His/GST-tagged E.coli His/GST Arg18~Ala202
Mouse AMBP-500M-B Recombinant Mouse AMBP Protein Pre-coupled Magnetic Beads HEK293
Mouse Ambp-590M Recombinant Mouse Ambp Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse AMBP-500M Recombinant Mouse AMBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ambp-225R Recombinant Rat Ambp Protein, His-tagged E.coli His Asp20~Ala202
Rat AMBP-646R Recombinant Rat AMBP Protein Mammalian Cell His
Rat Ambp-1152R Recombinant Rat Ambp protein, His-tagged HEK293 His Met1-Ala202
Rat Ambp-226R Recombinant Rat Ambp Protein, His/GST-tagged E.coli His/GST Asp20~Ala202
Rat AMBP-302R-B Recombinant Rat AMBP Protein Pre-coupled Magnetic Beads HEK293
Rat AMBP-302R Recombinant Rat AMBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle AMBP-129C Recombinant Cattle AMBP Protein, His-tagged E.coli N-His Ser20-Ala203
Zebrafish AMBP-11340Z Recombinant Zebrafish AMBP Mammalian Cell His
Chicken AMBP-5071C Recombinant Chicken AMBP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AMBP Related Research Area

AMBP involved in several pathways and played different roles in them. We selected most pathways AMBP participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Binding and Uptake of Ligands by Scavenger ReceptorsHPX;AMBP;APOA1B;LOC479668;NFX1;HSPH1;SCGB3A2;COL3A1;SAA1
Scavenging of heme from plasmaHPX;LOC479668;HP;NFX1;CD163;AMBP
Vesicle-mediated transportRALAA;SNF8;TRAPPC2;TBC1D8B;TCEAL4;SNX9A;CLINT1;MYO6B;COPE

AMBP has several biochemical functions, for example, IgA binding, calcium channel inhibitor activity, calcium oxalate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMBP itself. We selected most functions AMBP had, and list some proteins which have the same functions with AMBP. You can find most of the proteins on our site.

Function Related Protein
IgA bindingIGJ;FCAR;AMBP;FCAMR
calcium channel inhibitor activityCCDC109B;FKBP1AA;STX1A;FKBP1AB;PHPT1;PACSIN3;FKBP1B;SLC30A1B;SLC30A1
calcium oxalate binding
heme bindingCYP17A1;CYP2A13;CYP2P6;CYP3A25;XGB;CYP46A1.3;CYP2AA3;LPO;TDO2B
protein bindingBMPR1B;UHMK1;ATRX;STAR;GIPC1;CSRP2;ZNF2;STX11;PFDN5
protein homodimerization activityTFAP4;CREB3L3;RNF40;USF2;LMLN;HSP90AA1;STK25;GJC3;PDGFRA
serine-type endopeptidase inhibitor activitySERPINA1E;SPINK12;HRG;SERPINA12;SPINT1A;Serpina1b;FURIN;OVAL;SERPINB7
small molecule bindingPTGDSA;MUP17;MUP3;LCN2;AMBP;APODA.2;PAEP;LCN15;RBP4L

AMBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMBP here. Most of them are supplied by our site. Hope this information will be useful for your research of AMBP.

CTSB; FHL3; orf3_hevbu; eno1; COX8A; STAT3; PIK3CA; GRB2; PIK3R3; DAAM1; d-mannose; q99xu0_strp1

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Can AMBP serve as a diagnostic biomarker for inflammatory diseases or immune dysregulation, and what are the clinical implications of its expression levels or isoform variations? 12/01/2021

AMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.

What are the genetic and epigenetic factors that regulate AMBP expression, and how do they contribute to its physiological and pathological roles in the immune system? 03/15/2021

AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.

How does AMBP modulate the activity and function of immune cells, such as neutrophils, macrophages, or lymphocytes, and what signaling pathways are involved? 12/21/2020

AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.

How does AMBP participate in the regulation of complement activation and the modulation of the inflammatory response? 12/20/2019

AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.

Can AMBP be targeted for therapeutic interventions in immune-mediated disorders or inflammatory conditions, and what strategies can be employed to modulate its activity? 05/18/2019

Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.

What are the cellular and molecular functions of AMBP in the immune system and inflammation processes? 11/17/2018

AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.

What are the mechanisms of AMBP release or secretion from immune cells, and how can these processes be modulated for therapeutic purposes? 08/10/2018

AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.

How does AMBP contribute to tissue homeostasis and immune surveillance in different organs, and what are the consequences of its dysregulation in specific tissues or disease contexts? 11/05/2017

AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.

How does AMBP interact with other immune-related proteins, such as complement components or cytokines, and what are the functional consequences of these interactions? 10/29/2017

AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.

What are the structural features of AMBP and its domains that are essential for its immune-related functions? 10/09/2017

The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.

Customer Reviews (3)

Write a review
Reviews
08/27/2018

    Compatibility with various protein modification detection methods.

    08/05/2018

      Enhanced data reproducibility in protein quantification.

      03/20/2018

        Comprehensive profiling of protein expression patterns.

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