angpt1
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  • Official Full Name
  • Angiopoietin 1
  • Background
  • Angiopoietin-1 is a 498 amino acid secreted protein that undergoes post-translational glycosylation. It contains 1 fibrinogen C-terminal domain. Angiopoietin-1 is found to bind and activate TIE2 receptors by inducing its tyrosine phosphorylation. It is implicated in endothelial developmental processes later and is distinct from that of VEGF. Angiopoietin-1 appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Moreover, it mediates blood vessel maturation/stability. Angiopoietin-1 may also play an important role in early development of the heart. It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.
  • Synonyms
  • ANGPT1; AGP1; AGPT; ANG1; ANG-1
Cat.#:ANGPT1-159HTag:HIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT1 Protein, HIgG1 Fc-tagged
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Cat.#:Angpt1-539RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat Angpt1 protein, His-tagged
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Cat.#:ANGPT1-1065HTag:HlgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT1 Protein (Met1-Leu261 and Arg277-Phe498), HlgG1 Fc-tagged
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Cat.#:ANGPT1-1066CTag:HlgG1 Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus ANGPT1 Protein (Arg277-Phe498), HlgG1 Fc-tagged
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Cat.#:ANGPT1-115HTag:MYC
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Angiopoietin 1, Myc-tagged
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Cat.#:ANGPT1-2518HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Angiopoietin 1
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Cat.#:ANGPT1-27316THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPT1
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Cat.#:ANGPT1-27317THTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPT1, FLAG-tagged
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Cat.#:ANGPT1-434HTag:Flag
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Angiopoietin 1, FLAG-tagged
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Cat.#:COMP-Ang1-01Tag:N/A
Source (Host):CHOSpecies:Rat and Human
Product nameRecombinant Comp(Rat) and ANGPT1(Human), Flag-tagged
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Cat.#:Ang-1-3455HTag:N/A
Source (Host):HeLa cellsSpecies:Human
Product nameRecombinant Human Ang-1
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Cat.#:ANGPT1-157HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ANGPT1 Protein, His-tagged, Biotinylated
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Cat.#:ANGPT1-256HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ANGPT1 protein, GST-tagged
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Cat.#:ANGPT1-3455HTag:His
Source (Host):HELASpecies:Human
Product nameRecombinant Human ANGPT1 protein, His-tagged
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Cat.#:ANGPT1-35HTag:FLAG
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT1/COMP protein, FLAG-tagged
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Cat.#:ANGPT1-525HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPT1 protein, His-tagged
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Cat.#:ANGPT1-526HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPT1 protein, His-tagged
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Cat.#:ANGPT1-6881HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Angiopoietin 1
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Cat.#:Angpt1-4964MTag:N/A
Source (Host):COSSpecies:Mouse
Product nameRecombinant Mouse Angpt1 protein
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Cat.#:Angpt1-527MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Angpt1 protein, His-tagged
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Cat.#:Angpt1-528MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Angpt1 protein, His-tagged
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Cat.#:Angpt1-857MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Angpt1 Protein, His-tagged
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Cat.#:Angpt1-529RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Angpt1 protein, His-tagged
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Cat.#:ANGPT1-668RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ANGPT1 Protein
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Cat.#:ANGPT1-1171CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ANGPT1 Protein, His-tagged
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Cat.#:ANGPT1-324RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ANGPT1 Protein, His-tagged
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Cat.#:ANGPT1-523DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog ANGPT1 protein, His-tagged
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Cat.#:ANGPT1-524DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog ANGPT1 protein, His-tagged
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Cat.#:ANGPT1-4313CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ANGPT1
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Cat.#:ANGPT1-9324ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ANGPT1
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Cat.#:ANGPT1-8863HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ANGPT1 293 Cell Lysate
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Involved Pathway

ANGPT1 involved in several pathways and played different roles in them. We selected most pathways ANGPT1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
LOC608458; NFKB1; RASAL3; PGF; RASA3; MAPK3; PAK2; PLA2G12A; PLA2G3; RIN1
Rap signaling pathway
Itgam&Itgb2; FGF20; AKT1; PFN3; ITGB2L; RHOA; SRC; FGF21; FGF8; FYB
HIF- signaling pathway
PDHA1; STAT3; TIMP1; Il6ra; NOS3; HIF1A; IFNGR2; IGF1R; ERBB2; MAP2K2
PIK-Akt signaling pathway
Il4ra; ITGB5; PPP2R3C; GNB1; MAPK3; FIGF; PPP2CA; FGF8; OSM; TLR2
Rheumatoid arthritis
CCL2; HLA-DRB1; Ccl12; HLA-DMB; ATP6V0E2; CTLA4; FOS; ATP6V1G1; ATP6V0D1; ACP5

Protein Function

ANGPT1 has several biochemical functions, for example, protein binding, receptor tyrosine kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPT1 itself. We selected most functions ANGPT1 had, and list some proteins which have the same functions with ANGPT1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein GALT; POU5F1; SCN5A; RARG; RGMA; RUNX1T1; LSM10; RPS6KA3; ATP6V0C; HIST1H4E
Function receptor tyrosine kinase binding
Related Protein PITPNM3; NRG1; PTPN11; GAS6; ANXA5; MYOC; ANGPT4; PIK3R2; NCK1; PCNA

Interacting Protein

ANGPT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPT1.
daap-5; TEK

ANGPT1 Related Articles

Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
Scotti, L; Abramovich, D; et al. Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS). MOLECULAR AND CELLULAR ENDOCRINOLOGY 365:223-230(2013).

ANGPT1 Related Gene Family

Cytokines