ANXA1 Protein, annexin A1


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Official Full Name annexin A1
Background Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
Synonyms ANXA1; annexin A1; ANX1; LPC1; p35; annexin-1; calpactin-2; calpactin II; lipocortin I; chromobindin-9; annexin I (lipocortin I); phospholipase A2 inhibitory protein;
    • Species :
    • Chicken
    • Guinea pig
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • S
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ANXA1-001H Recombinant Human ANXA1 Protein, His-tagged E.coli His
    Human ANXA1-26347TH Recombinant Human ANXA1, His-tagged E.coli His
    Human ANXA1-26348TH Recombinant Human ANXA1 N/A
    Human ANXA1-26594TH Recombinant Human ANXA1 E.coli N/A
    Human ANXA1-33H Recombinant Human ANXA1 protein, His-tagged E.coli His
    Human ANXA1-504H Recombinant Human annexin A1 E.coli N/A
    Human ANXA1-5257H Recombinant Human Annexin A1, His-tagged E.coli His
    Human ANXA1-5277H Recombinant Human Annexin A1, T7-tagged E.coli T7
    Human ANXA1-627H Recombinant Human ANXA1 protein, GST-tagged Wheat Germ GST
    Human ANXA1-8839HCL Recombinant Human ANXA1 293 Cell Lysate HEK293 N/A
    Human ANXA1-9159H Recombinant Human ANXA1 protein E.coli His
    Mouse Anxa1-1122M Recombinant Mouse Anxa1 Protein, His-tagged E.coli His
    Mouse ANXA1-1710M Recombinant Mouse ANXA1 Protein Mammalian Cell His
    Mouse Anxa1-1712M Recombinant Mouse Anxa1 protein, His/S-tagged E.coli His/S
    Mouse Anxa1-1713M Recombinant Mouse Anxa1 Protein, His-tagged E.coli His
    Mouse Anxa1-1714M Recombinant Mouse Anxa1 Protein, His-tagged Yeast His
    Rat Anxa1-1345R Recombinant Rat Anxa1 protein, His & S-tagged E.coli His/S
    Rat ANXA1-688R Recombinant Rat ANXA1 Protein Mammalian Cell His
    Rabbit ANXA1-1346R Recombinant Rabbit ANXA1 protein, His & S-tagged E.coli His/S
    Rabbit ANXA1-1347R Recombinant Rabbit ANXA1 protein, His-tagged E.coli His
    Chicken ANXA1-7094C Recombinant Chicken ANXA1 Mammalian Cell His
    Pig ANXA1-133P Recombinant Pig ANXA1 Protein, His-tagged E.coli His
    Pig ANXA1-1344P Recombinant Pig ANXA1 protein, His & S-tagged E.coli His/S
    Guinea pig ANXA1-3491C Recombinant Cavia cutleri (Guinea pig) ANXA1, His-tagged E.Coli or Yeast His
    Guinea pig ANXA1-3492C Recombinant Cavia (Guinea pig) ANXA1, His-tagged, S tagged E.coli His/S

    ANXA1 involved in several pathways and played different roles in them. We selected most pathways ANXA1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class A/1 (Rhodopsin-like receptors) LPAR1; GPR65; TAC3; PROKR1; ADRa1A; DRD1; OPN1SW1; APLN; TAC1; CGA
    Formyl peptide receptors bind formyl peptides and many other ligands FPR-RS6; FPR-RS4; ANXA1; FPR-RS3; HEBP1
    G alpha (i) signalling events SSTR4; SOUL3; RGS11; RGS6; RGS7; PYYA; CCL27; NPB; ANXA1C; CNR2
    G alpha (q) signalling events FFAR3; PMCH; FPR-RS6; TRH; HCRT; GPR17; LPAR1; DGKQ; CHRM3; KALRNB
    GPCR downstream signaling INSL5; GRP; CCL35.2; ANXA1; HCAR1-2; ABR; ARHGEF18A; NMB; SSTR1; NMBB
    GPCR ligand binding TRH; OPN4A; OXER1; CRH; CRHR2; TAS2R13; RAMP3; CYSLTR1; PENKA; PENKB
    Gastrin-CREB signalling pathway via PKC and MAPK LPAR1; LPAR2A; ARHGEF25; NTS; NMB; TRPC7; ANXA1B; TRPC3; MGLL; OPN4.1
    Integrated Breast Cancer Pathway ERAL1; ZMIZ1; APOBEC3G; LGALS13; PLK3; DCAKD; DHTKD1; BACH1; EDAR; NAB1

    ANXA1 has several biochemical functions, for example, annealing helicase activity, calcium ion binding, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA1 itself. We selected most functions ANXA1 had, and list some proteins which have the same functions with ANXA1. You can find most of the proteins on our site.

    Function Related Protein
    annealing helicase activity BLM; RECQL4; RAD54L; SMARCAL1; ZRANB3; ANXA1; RECQL
    calcium ion binding DHH; PRRG2; CASQ2; MMP8; HSP90B1; DLK2; PLCD1B; MASP2; CANT1B; ACTN3B
    calcium-dependent phospholipid binding PLA2G4A; ANXA2B; ANXA1A; SYT9; ANXA1; SYTL4; C2CD4B; SYT12; SYTL1; ANXA2
    calcium-dependent protein binding NELF; MBL1; PLSCR3; VPS37C; PDCD6; SEC31A; KOP; VLDLR; A2M; MASP2
    double-stranded DNA-dependent ATPase activity ANXA1
    helicase activity HLTF; CHD8; SMARCA5; SHPRH; ZRANB3; YTHDC2; HELQ; NAV2; IFIH1; PIF1
    phospholipase A2 inhibitor activity ANXA2; CC10; ANXA1; ANXA3
    phospholipid binding PLA2G2A; SPTBN1; PACSIN1; APOA1; APOM; APOB; F10; OSBPL1A; APOC3; GLTPD1
    protein binding NCBP2; WARS; IST1; PPIL1; GSTO2; F10; FOXR2; TSKS; FZD7; SMARCD1
    protein binding, bridging TCAP; NCK1; STX1A; EVPL; GOLGA5; ADAP2; TRIM17; CSTA; RAD50; AMFR
    protein homodimerization activity DMRTB1; GRM6; ERBB3; HMGCL; CREB3L3; RAB11FIP3; BCL2L2; SUPV3L1; KIT; TERF2
    receptor binding TRIM24; IL29; POU2F1; CNPY3; TYROBP; NPPA; CD70; BLK; PVR; SMARCD1
    single-stranded DNA binding SSBP3B; TSNAX; RAD51L1; TREX1; WBP11; NABP1; C10orf2; NCL; NME2; POLR2G
    single-stranded RNA binding IFIT5; DDX58; CBX4; ENDOV; TLR8; ANXA1; DLX2; HMGB1; LUZP4; EIF2C3
    structural molecule activity CLTCA; KRT33B; NEFLB; KRT81; BVES; KRT31; SPRR2F; LAMA5; KRT3; TUBA1B

    ANXA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA1.


    Belvedere, R; Bizzarro, V; et al. Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells. BMC CANCER 14:-(2014).
    Wang, WL; Guan, SL; et al. Detection of circulating antibodies to linear peptide antigens derived from ANXA1 and DDX53 in lung cancer. TUMOR BIOLOGY 35:4901-4905(2014).

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