apoc2
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  • Official Full Name
  • apolipoprotein C-II
  • Background
  • This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
  • Synonyms
  • APOC2; apolipoprotein C-II; APO-CII; APOC-II; apolipoprotein C2;
Cat.#:APOC2-4773HTag:N/A
Source (Host):PurifiedSpecies:Human
Product nameHuman Apolipoprotein C-II
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Cat.#:APOC2-705HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APOC2 protein, GST-tagged
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Cat.#:APOC2-916HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOC2 Protein, His-tagged
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Cat.#:APOC2-1788MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APOC2 Protein
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Cat.#:Apoc2-2087MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Apoc2 protein, His & GST-tagged
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Cat.#:APOC2-304CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus APOC2 Protein, His-tagged
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Cat.#:APOC2-367RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey APOC2 Protein, His-tagged
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Cat.#:APOC2-2085HTag:His/T7
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse APOC2 protein, His & T7-tagged
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Cat.#:Apoc2-2086GTag:His/GST
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Apoc2 protein, His & GST-tagged
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Cat.#:Apoc2-3569CTag:GST
Source (Host):Mammalian CellsSpecies:Guinea pig
Product nameRecombinant Cavia porcellus (Guinea pig) Apoc2, GST-tagged
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Cat.#:APOC2-27331THTag:
Source (Host):Human PlasmaSpecies:Human
Product nameNative Human APOC2 protein
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Cat.#:APOC2-27332THTag:
Source (Host):Species:Human
Product nameNative Human APOC2
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Cat.#:APOC2-4904HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Apolipoprotein CII
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Cat.#:APOC2-8783HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APOC2 293 Cell Lysate
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Involved Pathway

APOC2 involved in several pathways and played different roles in them. We selected most pathways APOC2 participated on our site, such as Chylomicron-mediated lipid transport, HDL-mediated lipid transport, Lipid digestion, mobilization, and transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chylomicron-mediated lipid transport
APOA4B.2; MTP; APOC2; APOEB; APOBB.1; APOA1B; APOA5; APOA4A; APOEA; APOA4B.1
HDL-mediated lipid transport
ABCA1; APOA1B; CETP; BMP1A; AMN; Alb; APOC2
Lipid digestion, mobilization, and transport
Alb; APOA5; FABP1B.1; APOEB; APOC2; FABP12; ABCA1; LMF1; MTP; APOBB.1
Lipoprotein metabolism
MTP; APOA4B.1; ABCA1; CETP; APOA1B; APOEB; Alb; LPA; APOF; APOA4B.2
Metabolism
PFKLB; MED8; CYP2N13; SULT1ST6; OSBP; ETFA; SREBF2; ADHFE1; TMEM195; ITPKA
Metabolism of lipids and lipoproteins
MED16; ALOX5B.2; TMEM195; APOA5; MED7; PNPLA8; CYP2N13; CDIPT; LBR; THEM5
Retinoid metabolism and transport
AKR1C21; BCO2L; LRP12; CLPS; APOA4B.2; APOA4A; APOA4B.1; APOM; BCO2A; BCO2
Signal Transduction
CDC42EP3; ACVR1C; GPR132; OR52J3; PROK1; APLNR; EDNRAB; BCL9L; BCO2A; ARHGAP36

Protein Function

APOC2 has several biochemical functions, for example, lipase inhibitor activity, lipid binding, lipoprotein lipase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOC2 itself. We selected most functions APOC2 had, and list some proteins which have the same functions with APOC2. You can find most of the proteins on our site.
Function
Related Protein
Function lipase inhibitor activity
Related Protein APOC1; APOA2; APOA1; APOC3; FAF2; APOC2
Function lipid binding
Related Protein CADPS; LPAR4; APOL6; APOL1; FABP6; SNX10B; UNC119; ALOX8; FAM123A; BPIFB4
Function lipoprotein lipase activator activity
Related Protein APOC2; APOH; APOA5
Function phospholipase activator activity
Related Protein CCL5; GM2A; PDPK1; CCL8; APOC2; ARHGAP6; CCL3
Function phospholipase binding
Related Protein WAS; NEFL; SELE; PRKCZ; PDPK1; CALM2; LMNB1; CALM; SNCA; PARK2
Function protein homodimerization activity
Related Protein MCL1B; TRPM8; Trl; CR2; TPD52L1; TPD52; ADH5; GRPEL2; PRMT8; KCNN2

Interacting Protein

APOC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOC2.
d-mannose; APOE; APOA2; ALB; APOB