ARHGAP22
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Official Full Name
Rho GTPase activating protein 22
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Overview
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS;superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt;and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of;these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been;found for this gene. -
Synonyms
ARHGAP22; Rho GTPase activating protein 22; rho GTPase-activating protein 22; RhoGAP2; Rho GTPase activating protein 2; rho-type GTPase-activating protein 22; RhoGap22;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- ARHGAP22 Related Articles
ARHGAP22 involved in several pathways and played different roles in them. We selected most pathways ARHGAP22 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rho GTPase cycle | CHN1;OPHN1;FGD2;TAGAP;DEPDC7;ARHGAP17B;ARHGAP20;AKAP13;ARHGEF17 |
| Signal Transduction | RSPO2;DHRS9;CDH5;GPR39;KIF14;HEBP1;FABP11B;ADAM12;CNR2 |
| Signaling by Rho GTPases | ARHGAP17A;RHOT1A;ARHGAP32;ARHGAP44;ARHGAP11A;ARHGAP40;RHOT2;ARHGAP29;NOXO1A |
ARHGAP22 has several biochemical functions, for example, GTPase activator activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP22 itself. We selected most functions ARHGAP22 had, and list some proteins which have the same functions with ARHGAP22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | TBC1D10A;ECT2;RGS5;VPS9D1;RAP1GDS1;ARHGAP4;AGAP5;RACGAP1;DEPDC1B |
| molecular_function | LRRC45;DCDC2A;CATSPERG1;ARL6IP5B;DEFB7;MYG1;CCDC169;HAUS1;TAS2R126 |
ARHGAP22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP22 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP22.
PRKAA1
- Q&As
- Reviews
Q&As (9)
Ask a questionThe exact signaling pathways influenced by ARHGAP22 are still largely unknown. Since it is predicted to possess a RhoGAP domain, it suggests a potential involvement in modulating Rho GTPase-mediated signaling networks, which are crucial for numerous cellular processes ranging from cell migration to cytoskeletal organization.
The protein interaction network of ARHGAP22 is not well-defined. However, it has been reported to potentially interact with the Rho GTPase Cdc42, suggesting a role in regulating Cdc42-mediated signaling pathways.
The regulation of ARHGAP22 expression under different conditions has not been extensively examined. It is necessary to explore its expression patterns in various physiological and pathological contexts to determine if it is influenced by specific cues or stimuli.
There is limited evidence regarding the association between ARHGAP22 and cancer. While some studies have identified alterations in ARHGAP22 expression in certain cancer types, the functional implications and clinical significance are still unclear and require further investigation.
The therapeutic potential of targeting ARHGAP22 is not yet explored or well-understood due to limited research on its function. Further investigation into its role in cellular processes and disease pathogenesis is necessary before any targeted therapeutic strategies can be considered.
Currently, there are no specific animal models available to study ARHGAP22 function. Generating animal models, such as knockout mice or zebrafish models, could be valuable in investigating its in vivo role and understanding its significance in biological processes.
Limited information is available regarding post-translational modifications of ARHGAP22, as research on this protein is relatively scarce. Further studies are needed to explore any potential modifications and their functional consequences.
As of now, there are no known genetic disorders specifically linked to ARHGAP22 mutations or dysregulation. However, considering its potential role in cellular processes, it is plausible that future studies may unveil associations between ARHGAP22 variations and certain diseases or disorders.
While the specific tissue or cell type expression patterns of ARHGAP22 have not been extensively studied, existing data suggests that it is expressed in a wide range of tissues, including the brain, skeletal muscle, heart, liver, and kidneys.
Customer Reviews (8)
Write a reviewARHGAP22 protein is an enzyme involved in the digestion of carbohydrates, specifically starch.
A reliable manufacturer ensures the production and purification of ARHGAP22 protein, maintaining its quality and purity.
Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using ARHGAP22 protein.
the manufacturer's dedication to continuous improvement and innovation is evident in their ongoing efforts to enhance the ARHGAP22 protein's performance and optimize its applications.
This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.
Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.
Its purity and consistency guarantee accurate and consistent results, allowing for confident data interpretation and analysis.
The exceptional quality and reliability of the ARHGAP22 protein provided by the manufacturer cannot be overstated.
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