Recombinant Mouse Arhgap22 Protein, Myc/DDK-tagged

• Cat.No.: Arhgap22-1681M
• Product Overview: Purified recombinant protein of mouse full-length Rho GTPase activating protein 22 (cDNA clone MGC:47316 IMAGE:4237331), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.
• Molecular Mass: 55.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Arhgap22 Rho GTPase activating protein 22 [ Mus musculus (house mouse) ]
• Official Symbol: Arhgap22
• Synonyms: Arhgap22; Rho GTPase activating protein 22; RHO; RHOGAP2; p68RacGAP; B230341L19Rik; rho GTPase-activating protein 22; rho-type GTPase-activating protein 22
• Gene ID: 239027
• mRNA Refseq: NM_153800
• Protein Refseq: NP_722495
• UniProt ID: Q8BL80