| Description : |
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
78.6 kDa |
| Protein Length : |
714 amino acids |
| AA Sequence : |
MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI MKNWQQRWFV LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK HLFEISPGGA GEREKVPANP EALLLMASSQ RDMEDWVQAI RRVIWAPLGG GTARRSHAHP LEPLPPGIFG QRLEETVHHE RKYGPRLAPL LVEQCVDFIR ERGLTEEGLF RMPGQANLVR DLQDSFDCGE KPLFDSTTDV HTVASLLKLY LRELPEPVVP FARYEDFLSC AQLLTKDEGE GTLELAKQVS NLPQANYNLL RYICKFLDEV QAYSNVNKMS VQNLATVFGP NILRPQVEDP VTIMEGTSLV QHLMTVLIRK HSQLFTAPVP EGPTSPRGGL QCAVGWGSEE VTRDSQGEPG GPGLPAHRTS SLDGAAVAVL SRTAPTGPGS RCSPGKKVQT LPSWKSSFRQ PRSLSGSPKG GGSSLEVPII SSGGNWLMNG LSSLRGHRRA SSGDRLKDSG SVQRLSTYDN VPAPGLVPGI PSVASMAWSG ASSSESSVGG SLSSCTACRA SDSSARSSLH TDWALEPSPL PSSSEDPKSL DLDHSMDEAG AGASNSEPSE PDSPTREHAR RSEALQGLVT ELRAELCRQR TEYERSVKRI EEGSADLRKR MSRLEEELDQ EKKKYIMLEI KLRNSERARE DAERRNQLLQ REMEEFFSTL GSLTVGAKGA RAPK |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
