ATP4B
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Official Full Name
ATPase, H+/K+ exchanging, beta polypeptide
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Overview
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase;is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated;beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and;K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta;subunit of the gastric H+, K+-ATPase. -
Synonyms
ATP4B; ATPase, H+/K+ exchanging, beta polypeptide; potassium-transporting ATPase subunit beta; ATP6B; Gastric H(+)/K(+) ATPase subunit beta; ATPase H+/K+ exchanging beta polypeptide; ATPase H+/K+ transporting beta polypeptide; Gastric H K ATPase catalytic subunit; Gastric H+/K+ ATPase beta subunit; Gastric hydrogen potassium ATPase; Gastric hydrogen potassium ATPase beta; Hydrogen/potassium exchanging ATPase 4B; OTTHUMP00000178856; Potassium transporting ATPase beta chain; Potassium transporting ATPase subunit beta; Proton pump; Proton pump beta chain; gastric hydrogen-potassium ATPase, beta; potassium-transporting ATPase beta chain; ATPase, H+/K+ tra;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Human
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ATP4B involved in several pathways and played different roles in them. We selected most pathways ATP4B participated on our site, such as Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | COX6B2;ATP5D;PPA2;UQCRB;ATP5G1;ATP5IA;ATP5J2;ATP6V0A2;ATP5IB |
| Collecting duct acid secretion | ATP4A;ATP6V0D1;ATP6V0C;ATP6V0A1;TCIRG1;ATP6V1B1;ATP6V1E2;CA2;ATP6V0E |
| Gastric acid secretion | ATP1A4;ATP1B4;CALM2;CAMK2D;SSTR2;SLC26A7;GNAQ;PRKACG;PLCB2 |
ATP4B has several biochemical functions, for example, hydrogen:potassium-exchanging ATPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP4B itself. We selected most functions ATP4B had, and list some proteins which have the same functions with ATP4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrogen:potassium-exchanging ATPase activity | ATP6V1E1B;ATP4B;ATP4A;ATP12A |
| protein binding | PKN2;TSC22D4;MBD1;VPS54;POMP;UBE2B;TCF25;C16orf72;DOK4 |
ATP4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP4B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP4B.
CCNDBP1; BPGM; AGO3
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, several studies have been devoted to the development of drugs that can modulate ATP4B activity for the regulation of gastric acid secretion and the treatment of related gastric diseases.
ATP4B regulates gastric acid secretion through ATP binding and ion pump transport, and the specific mechanism involves the regulation of a variety of signaling pathways and hormones.
The abnormal expression of ATP4B can be used as an important indicator for the diagnosis and prognosis of some gastric-related diseases, but it needs to be comprehensively analyzed in combination with other clinical and molecular biological results.
Interacts with other proteins in the Parietal cells of the gastric mucosa, such as those associated with the parietal cells of the gastric mucosa, to jointly regulate the production and secretion of gastric acid.
Mutations in ATP4B may lead to abnormal changes in its intracellular localization and function, and then affect the normal secretion of gastric acid.
Yes, polymorphic variations in the ATP4B gene may be associated with the susceptibility and pathogenesis of gastric acid abnormalities, such as hyperacidity or hypoacidity.
Customer Reviews (2)
Write a reviewTheir wide range of products can meet our needs in different research areas.
ATP4B were highly reproducible and showed good process control and product quality.
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