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Acvr1c

  • Official Full Name

    activin A receptor, type IC

  • Overview

    ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
  • Synonyms

    ACVR1C; activin A receptor, type IC; ALK7; ACVRLK7; activin receptor type-1C; ALK-7; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Fc
  • GST
  • GST|His
  • hFc
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACVR1C-530H Active Recombinant Human ACVR1C, Fc-tagged, Biotinylated Human Cell Fc
Human ACVR1C-531H Active Recombinant Human ACVR1C, Fc-tagged Human Cell Fc
Human ACVR1C-9356H Recombinant Human ACVR1C, GST-tagged E.coli GST C-term-355a.a.
Human ACVR1C-6996H Recombinant Human ALK7, GST-tagged Sf9 Insect Cell GST 135 aa-end
Human ALK7-3271H Recombinant Human ALK7, GST-tagged Sf9 Insect Cell GST 3267
Human ACVR1C-255H Recombinant Human ACVR1C Protein, Fc-tagged HEK293 Fc
Human ACVR1C-189H Recombinant Human v protein, GST/His-tagged E.coli GST/His
Human ACVR1C-252H Recombinant Human ACVR1C Protein, GST-tagged Wheat Germ GST
Human ACVR1C-289H Recombinant Human ACVR1C Protein, His-tagged E.coli His Glu21~Ala493
Human ACVR1C-1019H Recombinant Human ACVR1C Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ACVR1C-829HF Recombinant Full Length Human ACVR1C Protein, GST-tagged In Vitro Cell Free System GST 493 amino acids
Human ACVR1C-0484H Recombinant Human ACVR1C Protein (Glu21-Ala493), His-tagged E.coli His Glu21-Ala493
Human ACVR1C-5045H Recombinant Human ACVR1C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACVR1C-1263H Recombinant Human ACVR1C protein, hFc&His-tagged HEK293 hFc&His Leu22-Glu113
Mouse Acvr1c-1523M Recombinant Mouse Acvr1c Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Acvr1c-822R Active Recombinant Rat Acvr1c Protein, Fc Chimera Mammalian cells Fc
Rat Acvr1c-502R Recombinant Rat Activin A Receptor, Type IC Mammalian cells N/A
Rat ACVR1C-493R Recombinant Rat ACVR1C Protein Mammalian Cell His
Rat Acvr1c-1R-B Recombinant Rat Acvr1c Protein Pre-coupled Magnetic Beads HEK293
Rat Acvr1c-1R Recombinant Rat Acvr1c Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ACVR1C-8816C Recombinant Cynomolgus ACVR1C, Fc tagged Human Cell Fc
Cynomolgus Monkey ACVR1C-1277CCL Recombinant Cynomolgus ACVR1C cell lysate Human Cell N/A
Rattus norvegicus (Rat) RFL-4260RF Recombinant Full Length Rat Activin Receptor Type-1C(Acvr1C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-493)
Rhesus ACVR1C-2311R Recombinant Rhesus ACVR1C protein, hFc-tagged HEK293 hFc Gly25-Glu113
Rhesus Macaque ACVR1C-232R Recombinant Rhesus monkey ACVR1C Protein, His-tagged Mammalian Cell His
Rhesus Macaque ACVR1C-60R Recombinant Rhesus Macaque ACVR1C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ACVR1C-60R-B Recombinant Rhesus Macaque ACVR1C Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Acvr1c involved in several pathways and played different roles in them. We selected most pathways Acvr1c participated on our site, such as Developmental Biology, MAPK signaling pathway, Regulation of signaling by NODAL, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acvr1c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyMEF2B;EBF1;GFRA2;LEFTY1;UNC5D;PHB;ARHGEF28;SCN2A;COL9A1A
MAPK signaling pathwayTGFB1;ARRB2B;PDGFRA;PPP3R1;CACNG1;HSC70;TGFB1A;CACNB1;MECOM
Regulation of signaling by NODALTDGF1;ACVR1C;CFC1;LEFTY1
Signal TransductionTHBS3B;DHRS3A;MAPK6;USP4;KAL1A;RDH14B;ARHGAP36;STAM2;RGS18
Signaling by ActivinFSTB;FSTL3;DRAP1;FOXH1;INHBAA;ACVR1C;FST
Signaling by NODALPCSK6;DRAP1;FOXH1;GDF1;ACVR1C;CFC1;TDGF1;LEFTY1
Signaling pathways regulating pluripotency of stem cellsBMI1;PIK3CB;SMAD4;WNT2B;HAND1;ESX1;BMPR2;MAPK13;BMP2
TGF-beta signaling pathwayID2B;LFT2;NOG3;PPP2CA;INHBB;GDF6A;BMP7B;RPS6KB2;ID1

Acvr1c has several biochemical functions, for example, ATP binding, activin receptor activity, type I, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Acvr1c itself. We selected most functions Acvr1c had, and list some proteins which have the same functions with Acvr1c. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAPKAPK2;MYH7;STK32C;MARK2;UBE2N;KIF3C;RLN1;TOR1B;FIGNL2
activin receptor activity, type IACVR1B;ACVRL1;ACVR1C
growth factor bindingBMPR2;ACVR2A;IGFBP2B;TEK;HTRA1B;REG3B;OSMR;ACVR2B;LTBP4
metal ion bindingAIFM4;CYB561A3A;GALNT5;ZFP426;NOB1;ETFDH;FBXO5;CBFA2T2;ZFP319
nodal bindingACVR1C;CFC1
receptor signaling protein serine/threonine kinase activityNEK4;BMPR2A;STK25A;STK24B;ACVR1BA;ACVRL1;PANK1A;PAK2B;TGFBR1A

Acvr1c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acvr1c here. Most of them are supplied by our site. Hope this information will be useful for your research of Acvr1c.

b4dyc6_human; HSP90AB1; INHBB

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