acvr1c
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  • Official Full Name
  • activin A receptor, type IC
  • Background
  • ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
  • Synonyms
  • ACVR1C; activin A receptor, type IC; ALK7; ACVRLK7; activin receptor type-1C; ALK-7; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7;
Cat.#:ACVR1C-1019HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1C Protein, MYC/DDK-tagged
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Cat.#:ACVR1C-289HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACVR1C Protein, His-tagged
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Cat.#:ACVR1C-189HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human v protein, GST/His-tagged
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Cat.#:ACVR1C-252HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACVR1C Protein, GST-tagged
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Cat.#:ACVR1C-255HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1C Protein, Fc-tagged
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Cat.#:ACVR1C-530HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACVR1C, Fc-tagged, Biotinylated
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Cat.#:ACVR1C-531HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACVR1C, Fc-tagged
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Cat.#:ACVR1C-6996HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK7, GST-tagged
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Cat.#:ACVR1C-9356HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACVR1C, GST-tagged
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Cat.#:ALK7-3271HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK7, GST-tagged
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Cat.#:ACVR1C-493RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACVR1C Protein
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Cat.#:Acvr1c-822RTag:Fc
Source (Host):NSO CellsSpecies:Rat
Product nameRecombinant Rat Acvr1c Protein, Fc Chimera
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Cat.#:ACVR1C-8816CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR1C, Fc tagged
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Cat.#:ACVR1C-232RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACVR1C Protein, His-tagged
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Cat.#:Acvr1c-502RTag:N/A
Source (Host):NS0Species:Rat
Product nameRecombinant Rat Activin A Receptor, Type IC
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Cat.#:ACVR1C-1277CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR1C cell lysate
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Involved Pathway

Acvr1c involved in several pathways and played different roles in them. We selected most pathways Acvr1c participated on our site, such as Developmental Biology, MAPK signaling pathway, Regulation of signaling by NODAL, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acvr1c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
EPHA4A; SCN2B; FRS2B; NTN1B; TRPC7; NADL1.1; COL9A1; MED7; TCF4; MED29
MAPK signaling pathway
JIP1; RPS6KA4; FGFR2; PLA2G4A; FGF12A; STK3; RASA2; CACNB1; NLK; NTRK1
Regulation of signaling by NODAL
LEFTY1; CFC1; ACVR1C; TDGF1
Signal Transduction
HHAT; MLN; BOC; DHRS9; FGD4; EVC; GPR31B; GPR4; RDH10; ARHGAP29
Signaling by Activin
FSTL3; ACVR1C; FOXH1; DRAP1; FSTB; FST; INHBAA
Signaling by NODAL
TDGF1; ACVR1C; GDF1; CFC1; FOXH1; DRAP1; PCSK6; LEFTY1
Signaling pathways regulating pluripotency of stem cells
WNT3; KLF4; PCGF6; APC; BMPR1A; WNT3A; WNT2; WNT2B; ID1; Fzd4
TGF-beta signaling pathway
ACVR1L; BMP6; BMPR1AA; BMPR1AB; BAMBIA; BMP7A; TGIF2; CUL1; AMHR2; BMP7B

Protein Function

Acvr1c has several biochemical functions, for example, ATP binding, activin receptor activity, type I, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Acvr1c itself. We selected most functions Acvr1c had, and list some proteins which have the same functions with Acvr1c. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATP1A3A; EPHA7; ATP11C; ATP1A1A.4; CHD8; SRPK3; ROCK2; MYO1D; MCM2; ACTR3
Function activin receptor activity, type I
Related Protein ACVRL1; ACVR1C; ACVR1B
Function growth factor binding
Related Protein FLT1; RHBDF2; SDCBP; ACVR2B; GHRHR; RHBDF1; A2M; HTRA1B; OSMR; NRP1
Function metal ion binding
Related Protein SOBPB; MGAT4C; PPM1F; GLIS2B; KLK1B3; NME2; ZFYVE28; SALL1; TRIM12A; ZFP330
Function nodal binding
Related Protein CFC1; ACVR1C
Function receptor signaling protein serine/threonine kinase activity
Related Protein ACVR2AA; PAK2B; STK25B; BMPR2B; PAK2A; BMPR1B; SLKA; BMPR1BB; STK26; STK24B

Interacting Protein

Acvr1c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acvr1c here. Most of them are supplied by our site. Hope this information will be useful for your research of Acvr1c.
b4dyc6_human; HSP90AB1; INHBB