Recombinant Mouse Acvr1c Protein, His Tagged

• Cat.No.: Acvr1c-11178M
• Product Overview: Mouse ALK-7 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 26-Glu 113 (Accession # Q8K348). This protein carries a polyhistidine tag at the C-terminus. Predicted N-terminus: Leu 26

Specification

• Species: Mouse
• Source: HEK293
• Tag: His
• Protein Length: 26-113 aa
• Description: ALK-7, also known as ACVR1C, is a Type I receptor for the TGF-beta family of signaling molecules. Upon ligand binding, it initiates intracellular signaling by phosphorylating cytoplasmic SMAD transcription factors. These activated SMADs then translocate to the nucleus to regulate gene expression, either directly or in complex with other transcription factors.
• Form: Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.
• Molecular Mass: The protein has a calculated MW of 11.4 kDa. The protein migrates as 8-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Purity: >90% as determined by SDS-PAGE. >90% as determined by SEC-HPLC.
• Storage: This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.

Gene Information

• Gene Name: Acvr1c activin A receptor, type IC [ Mus musculus (house mouse) ]
• Official Symbol: Acvr1c
• Synonyms: ACVR1C; activin A receptor, type IC; activin receptor type-1C; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7; ALK7; Alk-7; ACVRLK7; C230097P10
• Gene ID: 269275
• mRNA Refseq: NM_001033369
• Protein Refseq: NP_001028541
• UniProt ID: Q8K348