BARD1
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Official Full Name
BRCA1 associated RING domain 1
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Overview
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] -
Synonyms
BARD1; BRCA1 associated RING domain 1; BRCA1-associated RING domain protein 1; BRCA1-associated RING domain gene 1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Fc
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | BARD1-26645TH | Recombinant Human BARD1 | Wheat Germ | N/A | 100 amino acids |
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| Human | BARD1-074H | Recombinant Human BARD1 protein, GST-tagged | Wheat Germ | GST |
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| Human | BARD1-03HF | Recombinant Full Length Human BARD1 Protein, Fc tagged | E.coli | Fc |
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| Human | BARD1-228H | Recombinant Human BARD1 protein, His-tagged | E. coli | His | 428-777 aa |
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| Human | BARD1-1816HF | Recombinant Full Length Human BARD1 Protein, GST-tagged | In Vitro Cell Free System | GST | 777 amino acids |
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| Mouse | BARD1-2291M | Recombinant Mouse BARD1 Protein | Mammalian Cell | His |
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| Mouse | BARD1-963M-B | Recombinant Mouse BARD1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | BARD1-963M | Recombinant Mouse BARD1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | BARD1-940R | Recombinant Rat BARD1 Protein | Mammalian Cell | His |
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| Rat | BARD1-598R | Recombinant Rat BARD1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | BARD1-598R-B | Recombinant Rat BARD1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | BARD1-2905C | Recombinant Chicken BARD1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- BARD1 Related Articles
BARD1 involved in several pathways and played different roles in them. We selected most pathways BARD1 participated on our site, such as BARD1 signaling events, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with BARD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BARD1 signaling events | BARD1;RAD50;NPM1;CDK2;CSTF1;RBBP8 |
| Cell Cycle | CENPK;SMAD3A;CDT1;MCM8;MCM4;SKA1;CDCA8;CDC14AA;CCNE2 |
| Cell Cycle Checkpoints | HTATIP;MCM10;BARD1;RAD9;DBF4;RAD17;RAD9B;THRSP;HIST3H2BB |
| DNA Double Strand Break Response | UBE2V2;KDM4B;UIMC1;SMARCA5;RNF168;FAM175A;BRCC3;CHEK2;BRE |
| DNA Double-Strand Break Repair | PPP4R2A;RBBP8;WRN;UBE2V2;PAXIP1;CHEK1;POLD3;TOPBP1;DNA2 |
| DNA Repair | TIMELESS;INO80C;PPP4R2;BRE;ZNF830;INO80E;RHNO1;PPIE;RAD9A |
| G2/M Checkpoints | RAD17;BARD1;FAM175A;HUS1;UIMC1;RAD1;BRE;TP53BP1;RNF168 |
| G2/M DNA damage checkpoint | BRCC3;BARD1;BRE;BABAM1;THRSP;UIMC1;TP53BP1;FAM175A;RNF168 |
BARD1 has several biochemical functions, for example, RNA binding, kinase binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BARD1 itself. We selected most functions BARD1 had, and list some proteins which have the same functions with BARD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | DROSHA;EIF4G2A;CLUHA;CPEB1B;RPS25;RPS7;RPUSD1;RBM8A;EIF4B |
| kinase binding | WWC3;SLC2A1;EMP2;ATF5;CHP;PFKM;PIP5K1A;PPP2R5A;DLG1 |
| ligase activity | KCMF1;RBBP6;TRIM32;RTCD1;RNF114;UBR3;TRIM71;CMTM2A;LRSAM1 |
| protein binding | IL4R;MCPH1;NCOA5;EXOSC1;BCOR;LOXL2;ELK4;IRF1;RPL7A |
| protein heterodimerization activity | SOX5;TFAP2B;DLG4B;MPP7;CD3E;HER5;TLX1;HGF;TRP53 |
| protein homodimerization activity | ERCC5;IRAK1;PSPH;JUP;NR2C1;CITED1;CAMK2G;TFAP2B;NTRK1 |
| contributes_to ubiquitin-protein transferase activity | KLHL17;KLHDC8A;CCIN;KBTBD5;DDB2;KLHL10;KBTBD7;KEAP1B;KLHL14 |
| ubiquitin-protein transferase activity | RNF25;TRIM13;UBE2A;TRAF5;RNF213;RC3H2;FBXO21;TRAF4A;ZYG11 |
| zinc ion binding | BARD1;PRKCB;KAT7;FTR50;RNF152;LMO7B;MMP13;RNF44;AEBP1 |
BARD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BARD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BARD1.
BRCA1; CSTF2; par
- Q&As
- Reviews
Q&As (5)
Ask a questionBARD1 works in conjunction with BRCA1 to repair damaged DNA by facilitating homologous recombination, a crucial mechanism for DNA repair.
Dysregulated BARD1 expression or function can contribute to uncontrolled cell growth and tumor progression by compromising DNA repair mechanisms.
Genetic testing can identify mutations in the BARD1 gene, aiding in assessing an individual's predisposition to certain cancers.
BARD1 forms a complex with BRCA1, and mutations in either gene can compromise DNA repair, elevating the risk of cancer development.
BARD1 is also being studied in relation to its role in other diseases, including neurodegenerative disorders and infertility.
Customer Reviews (3)
Write a reviewResearchers highly recommend the BARD1 protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.
The BARD1 protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.
Researchers can rely on the BARD1 protein's specificity and sensitivity to obtain accurate and reliable results.
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