BARD1 Protein, BRCA1 associated RING domain 1


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Official Full Name BRCA1 associated RING domain 1
Background This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Synonyms BARD1; BRCA1 associated RING domain 1; BRCA1-associated RING domain protein 1; BRCA1-associated RING domain gene 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BARD1-074H Recombinant Human BARD1 protein, GST-tagged Wheat Germ GST
    Human BARD1-26645TH Recombinant Human BARD1 Wheat Germ N/A
    Mouse BARD1-2291M Recombinant Mouse BARD1 Protein Mammalian Cell His
    Rat BARD1-940R Recombinant Rat BARD1 Protein Mammalian Cell His
    Chicken BARD1-2905C Recombinant Chicken BARD1 Mammalian Cell His

    BARD1 involved in several pathways and played different roles in them. We selected most pathways BARD1 participated on our site, such as BARD1 signaling events, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with BARD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BARD1 signaling events CSTF1; CDK2; NPM1; RBBP8; BARD1; RAD50
    Cell Cycle WRAP53; MAD2L1; KIF2C; UBE2V2; MCM9; FKBP6; CCNA1; B9D2; NIPBL; NCAPH
    Cell Cycle Checkpoints UIMC1; HIST3H2BB; RNF168; CHEK1; BABAM1; CDKN1B; RAD17; TP53BP1; THRSP; RAD9B
    DNA Double Strand Break Response BRCC3; TP53BP1; RAD50; KDM4B; BAZ1B; KDM4A; CHEK2; RNF168; BRE; HTATIP
    DNA Double-Strand Break Repair TP53BP1; BRE; EME2; RTEL1; PPP4R2; RAD1; HUS1; BABAM1; RIF1; WRN
    DNA Repair YY1; GEN1; POLI; PPP4R2A; COPS2; INO80; ACTR5; USP45; APITD1; TP53BP1
    G2/M Checkpoints BRE; UIMC1; BABAM1; HUS1; RNF168; RAD9A; BARD1; THRSP; BRCC3; RAD9B
    G2/M DNA damage checkpoint THRSP; UIMC1; BARD1; RNF168; BABAM1; TP53BP1; FAM175A; BRCC3; BRE

    BARD1 has several biochemical functions, for example, RNA binding, kinase binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BARD1 itself. We selected most functions BARD1 had, and list some proteins which have the same functions with BARD1. You can find most of the proteins on our site.

    Function Related Protein
    kinase binding TRIP6; MOBKL1A; JAKMIP2; DLG4; SIT1; RASGRP3; JAKMIP1; PER3; DLG1; PARK2
    ligase activity PELI3; TTLL6; CBLC; ZNRF2; HERC5; TRIM41; UBE2G1B; RNF181; UCHL1; UBE2L3B
    protein binding CADM1; EPHA10; NKX2-1; PES1; ITGA6; RORA; SV2B; CYP2S1; CDPF1; GPATCH8
    protein heterodimerization activity HIST1H2BI; HIST1H3C; PHC2B; BCL2L2; H2AFY2; ADORA1; KCNB2; BCL11A; HIST1H2AF; BCL2L10
    protein homodimerization activity CHMP4C; BCL2A1; TENM2; GOT2; SNX1; HPS4; PDXK; PDCD6IP; ZHX3; GPD1L
    contributes_to ubiquitin-protein transferase activity BACH1; TCEB1B; ERCC8; DBN1; KBTBD13; TCEB3C; TCEB1; KLHL7; KBTBD5; BACH1A
    ubiquitin-protein transferase activity PEX2; FANCL; TRAF4; RNF220; NSMCE1; UBE2E1; UBE2Q2; RNF4; TRIM5; WWP1
    zinc ion binding LIMS3L; DTNBB; NR2C2; MME; ZNF75D; CDA; CHURC1; TRIM29; SETDB1A; CA4A

    BARD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BARD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BARD1.

    BRCA1; CSTF2; par

    Zhang, YQ; Pilyugin, M; et al. Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome. BRITISH JOURNAL OF CANCER 107:675-683(2012).
    Cosandey, V; Debrot, F; et al. Construction of a Peptide Microarray for Auto-antibody Detection. CHIMIA 66:803-806(2012).

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