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Recombinant Human BARD1 protein, GST-tagged

Cat.No. : BARD1-074H
Product Overview : Human BARD1 full-length ORF (BAG36925.1, 1 a.a. - 777 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 111.87 kDa
AA Sequence : MPDNRQPRNRQPRIRSGNEPRSAPA MEPDGRGAWAHSRAALDRLEKLLRC SRCTNILREPVCLGGCEHIFCSNCV SDCIGTGCPVCYTPAWIQDLKINRQ LDSMIQLCSKLRNLLHDNELSDLKE DKPRKSLFNDAGSKKNSIKMWFSPR SKKVRYVVSKASVQTQPAIKKDASA QQDSYEFVSPSPPADVSERAKKASA RSGKKQKKKTLAEINQKWNLEAEKE DGEFDSKEESKQKLVSFCSQPSVIS SPQINGEIDLLASGSLTESECFGSL TEVSLPLAEQIESPDTKSRNEVVTP EKVCKNYLTSKKSLPLENNGKRGHH NRLSSPISKRCRTSILSTSGDFVKQ TVPSENIPLPECSSPPSCKRKVGGT SGSKNSNMSDEFISLSPGTPPSTLS SSSYRRVMSSPSAMKLLPNMAVKRN HRGETLLHIASIKGDIPSVEYLLQN GSDPNVKDHAGWTPLHEACNHGHLK VVELLLQHKALVNTTGYQNDSPLHD AAKNGHMDIVKLLLSYGASRNAVNI FGLRPVDYTDDESMKSLLLLPEKNE SSSASHCSVMNTGQRRDGPLVLIGS GLSSEQQKMLSELAVILKAKKYTEF DSTVTHVVVPGDAVQSTLKCMLGIL NGCWILKFEWVKACLRRKVCEQEEK YEIPEGPRRSRLNREQLLPKLFDGC YFYLWGTFKHHPKDNLIKLVTAGGG QILSRKPKPDSDVTQTINTVAYHAR PDSDQRFCTQYIIYEDLCNYHPERV RQGKVWKAPSSWFIDCVMSFELLPL DS
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : BARD1 BRCA1 associated RING domain 1 [ Homo sapiens ]
Official Symbol : BARD1
Synonyms : BARD1; BRCA1 associated RING domain 1; BRCA1-associated RING domain protein 1; BARD-1; BRCA1-associated RING domain gene 1; BRCA1 associated RING domain 1 isoform eta; BRCA1 associated RING domain 1 isoform phi; BRCA1 associated RING domain 1 isoform alfa; BRCA1 associated RING domain 1 isoform beta; BRCA1 associated RING domain 1 isoform delta; BRCA1 associated RING domain 1 isoform gamma; BRCA1 associated RING domain 1 isoform epsilon;
Gene ID : 580
mRNA Refseq : NM_000465
Protein Refseq : NP_000456
MIM : 601593
UniProt ID : Q99728

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does BARD1 function in DNA repair? 08/30/2022

BARD1 works in conjunction with BRCA1 to repair damaged DNA by facilitating homologous recombination, a crucial mechanism for DNA repair.

How does BARD1 impact tumor progression? 06/23/2022

Dysregulated BARD1 expression or function can contribute to uncontrolled cell growth and tumor progression by compromising DNA repair mechanisms.

Are there diagnostic tests for BARD1 mutations? 07/08/2018

Genetic testing can identify mutations in the BARD1 gene, aiding in assessing an individual's predisposition to certain cancers.

How does BARD1 relate to BRCA1 in cancer risk? 02/08/2017

BARD1 forms a complex with BRCA1, and mutations in either gene can compromise DNA repair, elevating the risk of cancer development.

Apart from cancer, what other conditions might BARD1 be involved in? 07/06/2016

BARD1 is also being studied in relation to its role in other diseases, including neurodegenerative disorders and infertility.

Customer Reviews (3)

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02/06/2022

    Researchers highly recommend the BARD1 protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.

    04/27/2019

      The BARD1 protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.

      12/17/2018

        Researchers can rely on the BARD1 protein's specificity and sensitivity to obtain accurate and reliable results.

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