bin1
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  • Official Full Name
  • bridging integrator 1
  • Background
  • This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a;MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system;may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin.;Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and;activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in;cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different;isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
  • Synonyms
  • BIN1; bridging integrator 1; AMPHL; myc box-dependent-interacting protein 1; AMPH2; amphiphysin II; SH3P9; amphiphysin-like protein; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; MGC10367; DKFZp547F068
Cat.#:BIN1-16HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BIN1 Protein, MYC/DDK-tagged
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Cat.#:BIN1-10230HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BIN1, GST-tagged
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Cat.#:BIN1-192HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BIN1 protein, His-tagged
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Cat.#:BIN1-221HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BIN1 Protein, GST-tagged
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Cat.#:BIN1-222HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BIN1 Protein, GST-tagged
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Cat.#:BIN1-26316THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BIN1, His-tagged
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Cat.#:BIN1-26751THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BIN1, His-tagged
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Cat.#:BIN1-5167HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BIN1, His tagged
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Cat.#:BIN1-983RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BIN1 Protein
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Cat.#:BIN1-1662CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BIN1
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Cat.#:BIN1-2754HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Bridging Integrator 1, His-tagged
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Cat.#:BIN1-8454HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BIN1 293 Cell Lysate
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Involved Pathway

BIN1 involved in several pathways and played different roles in them. We selected most pathways BIN1 participated on our site, such as Endocytosis, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
SMAD3A; TGFB1A; SPG20; RAB7; ARRB2B; SNX32; GIT2B; RHOAB; ARAP1; FOLR1
Fc gamma R-mediated phagocytosis
PIK3CB; AKT2; FCGR2B; LIMK2; DOCK2; PLCG2; FCGR1A; MAPK3; GSN; PLA2G4A

Protein Function

BIN1 has several biochemical functions, for example, RNA polymerase binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIN1 itself. We selected most functions BIN1 had, and list some proteins which have the same functions with BIN1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase binding
Related Protein PHRF1; PPIB; PKN2; BIN1; ANP32B; GSG1; WDHD1; NEDD4; YTHDC2; TAF10
Function identical protein binding
Related Protein COL7A1; SERPINB1A; ACTB; PYCARD; MSANTD3; UGP2; APPL1; UBE4A; C1QL4; ALK
Function protein binding
Related Protein NUDCD2; TEKT1; SMAD6; GMPPA; AP1M2; SLC8A1; UBA1; RIPPLY3; ALCAM; ALG13
Function tau protein binding
Related Protein DYRK1A; HDAC6; S100B; APOE; SNCA; SERPINB1A; PPP2R2A; BIN1; FKBP4; AATF

Interacting Protein

BIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIN1.
p27958-pro_0000037576; q9wmx2-pro_0000037551; FBP1; XRCC4

BIN1 Related Articles

Xue, J; Zhou, D; et al. Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 292:R2406-R2416(2007).
Petzold, GC; Marcucci, M; et al. Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. ANNALS OF NEUROLOGY 55:286-290(2004).