BIN1

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BIN1

Official Full Name bridging integrator 1
Background This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a;MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system;may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin.;Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and;activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in;cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different;isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Synonyms BIN1; bridging integrator 1; AMPHL; myc box-dependent-interacting protein 1; AMPH2; amphiphysin II; SH3P9; amphiphysin-like protein; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; MGC10367; DKFZp547F068
    • Species :
    • Chicken
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIN1-10230H Recombinant Human BIN1, GST-tagged E.coli GST
    Human BIN1-16H Recombinant Human BIN1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BIN1-192H Recombinant Human BIN1 protein, His-tagged E.coli His
    Human BIN1-221H Recombinant Human BIN1 Protein, GST-tagged Wheat Germ GST
    Human BIN1-222H Recombinant Human BIN1 Protein, GST-tagged Wheat Germ GST
    Human BIN1-26316TH Recombinant Human BIN1, His-tagged E.coli His
    Human BIN1-26751TH Recombinant Human BIN1, His-tagged E.coli His
    Human BIN1-2754H Recombinant Human Bridging Integrator 1, His-tagged E.coli His
    Human BIN1-5167H Recombinant Human BIN1, His tagged E.coli His
    Human BIN1-8454HCL Recombinant Human BIN1 293 Cell Lysate HEK293 N/A
    Rat BIN1-983R Recombinant Rat BIN1 Protein Mammalian Cell His
    Chicken BIN1-1662C Recombinant Chicken BIN1 Mammalian Cell His

    BIN1 involved in several pathways and played different roles in them. We selected most pathways BIN1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis ARPC5LB; PIP5K1AA; AGAP2; LDLRA; RAB35; SNX1; CAPZB; GRK7B; IGF1RB; PIP5K1A
    Fc gamma R-mediated phagocytosis PRKCG; PLD2; VAV1; ASAP1; RPS6KB1; PIP5K1B; MARCKS; PPAP2A; PLA2G4A; RAF1

    BIN1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by BIN1 itself. We selected most functions BIN1 had, and list some proteins which have the same functions with BIN1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase binding NEDD4; PKN2; PPIB; ANP32B; TAF10; STOM; WDHD1; YTHDC2; PHRF1; GSG1
    identical protein binding DAAM1; BIRC5; LRRK1; LDHA; ACTG1; GRIN3A; TP73; RCAN1; E2F7; DIAP1
    protein binding SNAP91; FGFBP1; ATF3; ADCYAP1; PIM3; ERBB2; ZNF346; CCNL1; UBE2G2; NRBF2
    tau protein binding AATF; PPP2R2A; FKBP4; SNCA; APOE; S100B; SERPINB1A; BIN1; HDAC6; DYRK1A

    BIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIN1.

    p27958-pro_0000037576; q9wmx2-pro_0000037551; FBP1; XRCC4

    Xue, J; Zhou, D; et al. Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 292:R2406-R2416(2007).
    Petzold, GC; Marcucci, M; et al. Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. ANNALS OF NEUROLOGY 55:286-290(2004).

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