| Description : |
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
59.8 kDa |
| AA Sequence : |
MAEMGSKGVTAGKIASNVQKKLTRA QEKVLQKLGKADETKDEQFEQCVQN FNKQLTEGTRLQKDLRTYLASVKAM HEASKKLNECLQEVYEPDWPGRDEA NKIAENNDLLWMDYHQKLVDQALLT MDTYLGQFPDIKSRIAKRGRKLVDY DSARHHYESLQTAKKKDEAKIAKPV SLLEKAAPQWCQGKLQAHLVAQTNL LRNQAEEELIKAQKVFEEMNVDLQE ELPSLWNSRVGFYVNTFQSIAGLEE NFHKEMSKLNQNLNDVLVGLEKQHG SNTFTVKAQPSDNAPAKGNKSPSPP DGSPAATPEIRVNHEPEPAGGATPG ATLPKSPSQFEAPGPFSEQASLLDL DFDPLPPVTSPVKAPTPSGQSIPWD LWEPTESPAGSLPSGEPSAAEGTFA VSWPSQTAEPGPAQPAEASEVAGGT QPAAGAQEPGETAASEAASSSLPAV VVETFPATVNGTVEGGSGAGRLDLP PGFMFKVQAQHDYTATDTDELQLKA GDVVLVIPFQNPEEQDEGWLMGVKE SDWNQHKELEKCRGVFPENFTERVP TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
