|Official Full Name||bone morphogenetic protein 8b|
|Background||The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.|
|Synonyms||BMP8B; bone morphogenetic protein 8b; BMP8, bone morphogenetic protein 8 (osteogenic protein 2); OP 2; osteogenic protein 2; BMP-8; BMP-8B; BMP8B_HUMAN; Bone morphogenetic protein 8; OP-2; OP2; OTTHUMP00000010836; bone morphogenetic protein 8 (osteogenic protein 2); dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); BMP8|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
BMP8B involved in several pathways and played different roles in them. We selected most pathways BMP8B participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP8B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|TGF-beta signaling pathway||INHBE; INHBB; MYCB; BMP8A; BMP7B; BMPR1B; AMHR2; ROCK1; PPP2R1B; LEFTY2|
|Hippo signaling pathway||ID2; ITGB2L; WWTR1; APC; PRKCI; CDH1; SMAD7; WNT5A; WNT8A; AFP|
BMP8B has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP8B itself. We selected most functions BMP8B had, and list some proteins which have the same functions with BMP8B. You can find most of the proteins on our site.
|BMP receptor binding||BMP7A; BMP8A; BMP7; BMP4; BMP8B; BMP2B; PYCARD; BMP7B; BMP3; BMP2|
|cytokine activity||CD70; CCL20B; TNFSF13; IFNA6; IL17D; GREM1; SLURP1; WNT1; FLT3LG; IFNK|
|growth factor activity||JAG2; GDNFA; BMP1; GMFB; CXCL12; INHBC; GDF3; IL5; PDGFA; HBEGFA|
|transforming growth factor beta receptor binding||GDF10B; BMP8A; LFT1; BMP3; LFT2; GDF1; GDF6; GDF9; SMURF2; BMP15|
BMP8B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP8B here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP8B.
WFIKKN2; WFIKKN1; ABL1; FYN