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CALCA

  • Official Full Name

    calcitonin-related polypeptide alpha

  • Overview

    This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    Alpha CGRP; CALC 1; CALC A; CALC1; CALCA; Calcitonin related polypeptide alpha; CGRP 1; CGRP; CGRP I; CGRP1; CGRPI; CT; Katacalcin; KC; MGC126648;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Dog
  • Eel
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • mFc
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CALCA-317H Active Recombinant Human Calcitonin-related polypeptide alpha Human N/A
Human CALCA-236H Recombinant Human CALCA protein(Met1-Asn141), mFc-tagged HEK293 C-mFc Met1-Asn141
Human CALCA-230H Recombinant Human CALCA, His-tagged E.coli His
Human CALCA-708H Recombinant Human CALCA Protein, His/GST-tagged E.coli His/GST Ala25~Cys85
Human CALCA-047H Recombinant Human Calcitonin-Related Polypeptide Alpha, His-tagged E.coli His
Human CALCA-8634H Recombinant Human CALCA, GST tagged E.coli GST
Human CALCA-817H Recombinant Human CALCA Protein, His-tagged E.coli His
Human CALCA-10658H Recombinant Human CALCA, GST-tagged E.coli GST C-term-77a.a.
Human CALCA-519H Recombinant Human CALCA Protein, His-tagged HEK293 His
Human CALCA-0289H Recombinant Human CALCA Protein, GST-Tagged Wheat Germ GST
Human CALCA-7895HCL Recombinant Human CALCA 293 Cell Lysate HEK293 N/A
Human CALCA-301179H Recombinant Human CALCA protein, GST-tagged E.coli GST Cys85-Pro116
Human CALCA-101H Human Calcitonin Reference standard N/A
Human CALCA-3047HF Recombinant Full Length Human CALCA Protein, GST-tagged In Vitro Cell Free System GST 141 amino acids
Human CALCA-332H Recombinant Human CALCA protein E.coli N/A 116
Human CALCA-0063H Recombinant Human CALCA Protein HEK293 cells
Human CALCA-3496H Recombinant Human CALCA protein, His-tagged E.coli His 26-116 aa
Human CALCA-150H Recombinant Human CALCA protein, GST-tagged E.coli GST 26 - 116 aa
Human CALCA-5296H Recombinant Human CALCA protein, GST-tagged E.coli GST 83-118aa
Human CALCA-0523H Recombinant Human CALCA Protein (Ala26-Asn141), N-His-tagged E.coli N-His Ala26-Asn141
Human CALCA-613H Recombinant Human CALCA Protein, His&GST-tagged E.coli N-His&GST Cys85-Pro116
Human CALCA-0522H Recombinant Human CALCA Protein (Tyr58-Asn141), C-His-tagged E.coli C-His Tyr58-Asn141
Human CALCA-0811H Recombinant Human CALCA Protein (Ala26-Asn141), C-His tagged Mammalian cells C-His Ala26-Asn141
Human CALCA-5181H Recombinant Human CALCA Protein (Met1-Asn141), C-His tagged Mammalian cells C-His Met1-Asn141
Human CALCA-1255H Recombinant Human CALCA protein, His-tagged Yeast His 121-141aa
Human CALCA-07H Active Recombinant Human CALCA Protein E.coli
Human CALCA-0064H Recombinant Human CALCA Protein HEK293 cells
Mouse Calca-709M Recombinant Mouse Calca Protein, His-tagged E.coli His Val26~Asn136
Mouse CALCA-2643M Recombinant Mouse CALCA Protein Mammalian Cell His
Mouse Calca-795M Recombinant Mouse Calca protein, His & GST-tagged E.coli His/GST Val26~Asn136 (Accession # P70160)
Mouse Calca-745M Recombinant Mouse Calca Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CALCA-1186M Recombinant Mouse CALCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CALCA-1186M-B Recombinant Mouse CALCA Protein Pre-coupled Magnetic Beads HEK293
Rat Calca-796R Recombinant Rat Calca protein, His-tagged E.coli His Val26~Asn136
Rat CALCA-1087R Recombinant Rat CALCA Protein Mammalian Cell His
Rat Calca-862R Recombinant Rat Calca Protein, His&SUMO-tagged E.coli N-His&SUMO Cys85-Pro116
Rat CALCA-751R-B Recombinant Rat CALCA Protein Pre-coupled Magnetic Beads HEK293
Rat CALCA-751R Recombinant Rat CALCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Dog CALCA-707D Recombinant Dog CALCA Protein, His-tagged E.coli His Ala26~Arg130
Dog CALCA-2620D Recombinant Dog CALCA protein, His-SUMO-tagged E.coli His-SUMO 85-116aa
Eel CALCA-91E Eel Calcitonin Reference standard N/A
Zebrafish CALCA-601Z Recombinant Zebrafish CALCA Mammalian Cell His
Chicken CALCA-794C Recombinant Chicken CALCA protein, His-tagged E.coli His Ala26~Asn138
Chicken CALCA-3807C Recombinant Chicken CALCA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CALCA Related Articles

CALCA involved in several pathways and played different roles in them. We selected most pathways CALCA participated on our site, such as Amyloid formation, Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CALCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amyloid formationCALCA;NAT8B;CST3;TTR;HIST4H4;LTF;SAA1;MFGE8;SEMG1
Calcitonin-like ligand receptorsCALCRL;CALCB;RAMP2;RAMP3;ADM2A;RAMP1;ADM;CALCA;ADM2
Class B/2 (Secretin family receptors)ADM;ADM2;CRH;GNB5A;GNB3B;CRHR1;CD97;ADCYAP1R1;SCT
EndothelinMYL1;EDNRA;EDN1;CALCRL;EDNRB;CALCA;RAMP1;CNN1;ECE1
G alpha (s) signalling eventsADORA2A;PTHLH;CRHB;GCGA;RLN3;VIP;ADCYAP1;VIP2;PTH
GPCR downstream signalingPENK;GPR17;TAS2R7;RLN3;OXGR1A.1;NPSR1;SSTR4;CCL35.1;HCRT
GPCR ligand bindingAPLNR;SSTR4;AGTR2;GPR17;RGS1;GPR31B;GPR120;CRHR1;CHRM4
Metabolism of proteinsEEF1A1;TBCB;RHBDL1;RNF2;YIF1A;PHC3;GALNT6;TPP1;B3GNT6

CALCA has several biochemical functions, for example, calcitonin receptor binding, hormone activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CALCA itself. We selected most functions CALCA had, and list some proteins which have the same functions with CALCA. You can find most of the proteins on our site.

Function Related Protein
calcitonin receptor bindingCALCA;RAMP1
hormone activityUCN3;INHBB;UCN2;PRL;BNP;ADM2;PRL5A1;SST;IGF3
identical protein bindingCLDN9;ZBTB16;SIAH1;CLDN10;STAT6;SLIT2;CSK;SERPINA1;MIEF1
protein bindingTPSAB1;CDC25B;XPO6;HYI;MOCOS;BCL2A1;SOX13;KRIT1;BST2
protein complex bindingTULP2;TAPBPL;CYFIP1;FYB;CRHR1;PRKACA;FADD;EPCAM;TRAF2
receptor bindingNPPC;ACOX1;HACL1;ALCAM;TDGF1;HSPA1B;DRD1A;MIF;NSG1

CALCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALCA here. Most of them are supplied by our site. Hope this information will be useful for your research of CALCA.

ATP2B4; ATP2B2; CALCR

Tavares, E; Maldonado, R; et al. Immunoneutralization of Endogenous Aminoprocalcitonin Attenuates Sepsis-Induced Acute Lung Injury and Mortality in Rats. AMERICAN JOURNAL OF PATHOLOGY 184:3069-3083(2014).
Camacho, CP; Lindsey, SC; et al. Measurement of Calcitonin and Calcitonin Gene-Related Peptide mRNA Refines the Management of Patients with Medullary Thyroid Cancer and May Replace Calcitonin-Stimulation Tests. THYROID 23:308-316(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
What is the chemical structure of calcitonin, and how does it regulate calcium levels in the body? 05/26/2021

CALCA is a peptide hormone. It regulates calcium levels by reducing bone resorption, which lowers blood calcium levels, and by enhancing calcium excretion by the kidneys.

How is calcitonin synthesized from the CALCA gene? 10/14/2020

Calcitonin is synthesized from the CALCA gene through tissue-specific alternative RNA splicing of gene transcripts and cleavage of inactive precursor proteins.

What is the role of calcitonin gene-related peptide (CGRP), another product of CALCA? 11/23/2019

CGRP functions as a vasodilator and plays a role in antimicrobial defense in addition to its role in neurovascular regulation.

How is CALCA production affected by changes in serum calcium levels? 08/08/2018

An increase in serum calcium levels stimulates the secretion of CALCA to help reduce the excess calcium in the bloodstream.

Can you explain the relationship betweCALCA and parathyroid hormone (PTH)? 06/02/2018

CALCA and PTH are antagonistic hormones. PTH increases blood calcium levels, whereas calcitonin reduces them. They work together to maintain calcium homeostasis.

Customer Reviews (3)

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Reviews
05/06/2022

    Quality laboratory materials, on-time delivery, and the best customer service.

    01/22/2021

      Impressed by the product quality and quick delivery. Great job!

      07/11/2019

        I love their laboratory products, and the delivery is super speedy.

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