calca
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  • Official Full Name
  • calcitonin-related polypeptide alpha
  • Background
  • This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • Alpha CGRP; CALC 1; CALC A; CALC1; CALCA; Calcitonin related polypeptide alpha; CGRP 1; CGRP; CGRP I; CGRP1; CGRPI; CT; Katacalcin; KC; MGC126648
Cat.#:CALCA-0289HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CALCA Protein, GST-Tagged
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Cat.#:CALCA-230HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CALCA, His-tagged
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Cat.#:CALCA-317HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Calcitonin-related polypeptide alpha
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Cat.#:CALCA-047HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Calcitonin-Related Polypeptide Alpha, His-tagged
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Cat.#:CALCA-10658HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CALCA, GST-tagged
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Cat.#:CALCA-236HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CALCA, Fc-tagged
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Cat.#:CALCA-519HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CALCA Protein, His-tagged
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Cat.#:CALCA-708HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CALCA Protein, His/GST-tagged
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Cat.#:CALCA-817HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CALCA Protein, His-tagged
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Cat.#:CALCA-8634HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CALCA, GST tagged
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Cat.#:CALCA-2643MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CALCA Protein
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Cat.#:Calca-709MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Calca Protein, His-tagged
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Cat.#:Calca-795MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Calca protein, His & GST-tagged
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Cat.#:CALCA-1087RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CALCA Protein
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Cat.#:Calca-796RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Calca protein, His-tagged
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Cat.#:CALCA-707DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog CALCA Protein, His-tagged
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Cat.#:CALCA-3807CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CALCA
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Cat.#:CALCA-794CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken CALCA protein, His-tagged
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Cat.#:CALCA-601ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CALCA
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Cat.#:CALCA-7895HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CALCA 293 Cell Lysate
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Cat.#:CALCA-101HTag:
Source (Host):Species:Human
Product nameHuman Calcitonin Reference standard
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Cat.#:CALCA-91ETag:
Source (Host):Species:Eel
Product nameEel Calcitonin Reference standard
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Involved Pathway

CALCA involved in several pathways and played different roles in them. We selected most pathways CALCA participated on our site, such as Amyloid formation, Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CALCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amyloid formation
LTF; NAT8B; ODAM; HIST4H4; NAT8; SEMG1; CALCA; SAA1; CEACAM21; CST3
Calcitonin-like ligand receptors
ADM; ADM2; RAMP3; CALCB; CALCRL; CALCA; ADM2A; RAMP2; RAMP1
Class B/2 (Secretin family receptors)
GNB3A; EMR1; CRH; CRHB; CRHR2; ADCYAP1B; GHRH; CD97; RCA2.1; GCGA
Endothelin
CALCRL; EDN1; MYL1; RAMP1; CALCA; EDNRA; EDNRB; ECE1; CNN1
G alpha (s) signalling events
ADCYAP1; RLN3A; TAAR1; SCT; VIP2; CRHR2; ADORA2B; ADCYAP1R1; RAMP2; VIP
GPCR downstream signaling
PPY; MGLL; CCL35.2; PROKR1A; RLN2; PMCH; RGS12; CALCA; EDN3; PTH
GPCR ligand binding
EMR3; GPR4; ADM2; EMR2; KEL; CCRL2; NMB; CD97; GPR55A; ADORA2B
Metabolism of proteins
EEF1B2; ARSD; A4GNT; THSD7A; PAPPAB; DOHH; DNAJC24; GZMH; B3GALTL; SSPO

Protein Function

CALCA has several biochemical functions, for example, calcitonin receptor binding, hormone activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CALCA itself. We selected most functions CALCA had, and list some proteins which have the same functions with CALCA. You can find most of the proteins on our site.
Function
Related Protein
Function calcitonin receptor binding
Related Protein RAMP1; CALCA
Function hormone activity
Related Protein INHA; INSL5B; CSHL1; PRL7A2; C1QTNF9; SMTLB; SST3; AMH; STC2; PRL7A1
Function identical protein binding
Related Protein CEACAM16; C1QTNF9; GCC2; MLL1; KDM6A; ITGB3; NCAM1; DIAP1; PYDC3; DDX58
Function protein binding
Related Protein CCT7; MESDC1; RHOB; MR1; EXOSC4; DES; RASSF1; FBXO44; TXN; LMAN1
Function protein complex binding
Related Protein DRD1; MYC; CRTAP; SLC27A5; LAMB3; CDK2; SKIL; GNB2; DISC1; NDUFA9
Function receptor binding
Related Protein ACOX3; PKD2; FGF24; CD2; ACOT8; CNPY3; CNTFR; P2RX4; CADM4; ACOT2

Interacting Protein

CALCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALCA here. Most of them are supplied by our site. Hope this information will be useful for your research of CALCA.
ATP2B4; ATP2B2; CALCR

CALCA Related Articles

Tavares, E; Maldonado, R; et al. Immunoneutralization of Endogenous Aminoprocalcitonin Attenuates Sepsis-Induced Acute Lung Injury and Mortality in Rats. AMERICAN JOURNAL OF PATHOLOGY 184:3069-3083(2014).
Camacho, CP; Lindsey, SC; et al. Measurement of Calcitonin and Calcitonin Gene-Related Peptide mRNA Refines the Management of Patients with Medullary Thyroid Cancer and May Replace Calcitonin-Stimulation Tests. THYROID 23:308-316(2013).