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Recombinant Human CALCA Protein, His-tagged

Cat.No. : CALCA-817H
Product Overview : Recombinant Human CALCA, transcript variant 2, fused with His tag at C-terminal was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Form : Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4
Molecular Mass : 10.5kD
AA Sequence : YVQMKASELEQEQEREGSSLDSPRS KRCGNLSTCMLGTYTQDFNKFHTFP QTAIGVGAPGKKRDMSSDLERDHRP HVSMPQNANVEHHHHHH
Endotoxin : Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
Purity : >95% as determined by SDS-PAGE and Coomassie blue staining
Concentration : Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : CALCA calcitonin-related polypeptide alpha [ Homo sapiens ]
Official Symbol : CALCA
Synonyms : CALCA; calcitonin-related polypeptide alpha; CALC1, calcitonin 1; calcitonin; calcitonin gene-related peptide 1; calcitonin; katacalcin; calcitonin 1; alpha-type CGRP; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; CT; KC; CGRP; CALC1; CGRP1; CGRP-I; MGC126648;
Gene ID : 796
mRNA Refseq : NM_001033952
Protein Refseq : NP_001029124
MIM : 114130
UniProt ID : P01258

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is the chemical structure of calcitonin, and how does it regulate calcium levels in the body? 05/26/2021

CALCA is a peptide hormone. It regulates calcium levels by reducing bone resorption, which lowers blood calcium levels, and by enhancing calcium excretion by the kidneys.

How is calcitonin synthesized from the CALCA gene? 10/14/2020

Calcitonin is synthesized from the CALCA gene through tissue-specific alternative RNA splicing of gene transcripts and cleavage of inactive precursor proteins.

What is the role of calcitonin gene-related peptide (CGRP), another product of CALCA? 11/23/2019

CGRP functions as a vasodilator and plays a role in antimicrobial defense in addition to its role in neurovascular regulation.

How is CALCA production affected by changes in serum calcium levels? 08/08/2018

An increase in serum calcium levels stimulates the secretion of CALCA to help reduce the excess calcium in the bloodstream.

Can you explain the relationship betweCALCA and parathyroid hormone (PTH)? 06/02/2018

CALCA and PTH are antagonistic hormones. PTH increases blood calcium levels, whereas calcitonin reduces them. They work together to maintain calcium homeostasis.

Customer Reviews (3)

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Reviews
05/06/2022

    Quality laboratory materials, on-time delivery, and the best customer service.

    01/22/2021

      Impressed by the product quality and quick delivery. Great job!

      07/11/2019

        I love their laboratory products, and the delivery is super speedy.

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