casp6
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  • Official Full Name
  • caspase 6, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CASP6; caspase 6, apoptosis-related cysteine peptidase; MCH2; caspase-6; apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine protease;
Cat.#:CASP6-0426HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP6 Protein
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Cat.#:CASP6-0427HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP6 Protein, GST-Tagged
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Cat.#:CASP6-568HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP6 Protein, His-tagged
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Cat.#:CASP6-566BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine CASP6 Protein, His-tagged
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Cat.#:CASP6-10735HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP6, GST-tagged
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Cat.#:CASP6-26830THTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP6
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Cat.#:CASP6-298HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP6 Protein, His-tagged
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Cat.#:Casp6-16MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp6 protein, His-tagged
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Cat.#:CASP6-2754MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP6 Protein
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Cat.#:CASP6-6291CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CASP6
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Cat.#:CASP6-2695ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CASP6
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Cat.#:CASP6-601HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Caspase 6, Apoptosis-related Cysteine Peptidase
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Cat.#:CASP6-7834HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP6 293 Cell Lysate
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Involved Pathway

CASP6 involved in several pathways and played different roles in them. We selected most pathways CASP6 participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
PPP3CC; HDR; HIST1H1D; CASP6L1; HMGB2A; H1F0; PTBP3; BCL2L11; BAD; GZMC

Protein Function

CASP6 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP6 itself. We selected most functions CASP6 had, and list some proteins which have the same functions with CASP6. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activity
Related Protein USP10; CTSSB.1; USP2; USP19; PDIA3; PSD; USP50; USP37; USP5; USP12A
Function cysteine-type endopeptidase activity involved in execution phase of apoptosis
Related Protein CASP3A; CASP3B; CASP6; CASP7; Casp3; CASP6L2; CASP6L1
Function cysteine-type peptidase activity
Related Protein SENP7; DESI2; CTS7; DESI1; USP43; SOLH; CTSL2; ESPL1; CTSJ; CASPBL
Function identical protein binding
Related Protein MCIN; SCHIP1; NPR2; ATL1; TLE1; CD74; DRD4; PUF60; APP; RCAN1
Function protein binding
Related Protein C4orf19; TOM1L1; FSTL3; C1orf38; HDAC5; INCENP; SEC23B; FGFR1B; AQP5; WNK1

Interacting Protein

CASP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP6.
act-veid; NUCB2; NUCB1; PARP10; ATG16L1; APP; CASP3; SATB1; PRKAB2; CHD3; PIN1; TAB1; MAPK6; IKBKG