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CBY1

Official Full Name

chibby homolog 1 (Drosophila)
Overview

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CBY1-5152H	Recombinant Human CBY1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CBY1-147HCL	Recombinant Human CBY1 lysate	HEK293	N/A		Inquiry
Human	CBY1-596H	Recombinant Human CBY1 Protein, His-tagged	E.coli	His	Lys12~Glu115	Inquiry
Human	CBY1-2720H	Recombinant Human CBY1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	CBY1-1795H	Recombinant Human CBY1 protein, GST-tagged	E.coli	GST	41-126 aa	$319 / 25ug
Human	CBY1-3781HF	Recombinant Full Length Human CBY1 Protein, GST-tagged	In Vitro Cell Free System	GST	126 amino acids	Inquiry
Human	CBY1-4974H	Recombinant Human CBY1 protein, GST-tagged	E.coli	GST	1-126aa	Inquiry
Human	CBY1-1582H	Recombinant Human CBY1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CBY1-1388H	Recombinant Human CBY1 Protein (Lys12-Glu115), His tagged	E.coli	His	Lys12-Glu115	Inquiry
Mouse	Cby1-597M	Recombinant Mouse Cby1 Protein, His-tagged	E.coli	N/A	Ile7~Lys127	Inquiry
Mouse	Cby1-1978M	Recombinant Mouse Cby1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	CBY1-1129Z	Recombinant Zebrafish CBY1	Mammalian Cell	His		Inquiry
Chicken	CBY1-5398C	Recombinant Chicken CBY1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CBY1 Related Articles

CBY1 involved in several pathways and played different roles in them. We selected most pathways CBY1 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Deactivation of the beta-catenin transactivating complex	TLE4;SOX6;PYGO1;SOX4A;RBBP5;TLE1;SOX32;BCL9L;PYGO2
Regulation of Wnt-mediated beta catenin signaling and target gene transcription	TLE2;CYR61;MYOG;TLE4;KCNIP4;AES;TLE1;ZCCHC12;IGF2BP1
Signal Transduction	TULP3;ACVR1C;TLE3;RHOUA;APOC2;OR10A5;PROKR1A;ADM2;FMNL2
Signaling by Wnt	HECW1;ASH2L;SOX9A;RYK;TLE3B;RBBP5;BCL9;TNKS;LEO1
TCF dependent signaling in response to WNT	SOX4A;RSPO3;DACT1;USP34;CBY1;BCL9L;KREMEN1;TNKS;LEO1

CBY1 has several biochemical functions, for example, beta-catenin binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBY1 itself. We selected most functions CBY1 had, and list some proteins which have the same functions with CBY1. You can find most of the proteins on our site.

Function	Related Protein
beta-catenin binding	TCF7L1B;CXADR;BTRC;TCF7;APC2;MED12;SLC9A3R1;TCF7L2;TBL1XR1
identical protein binding	TTR;ALDOA;SH2B2;RABAC1;CAD;SMG9;BNIP3;RNF4;LYZ
protein binding	KCNE2;NATD1;SV2B;ACP1;TTN;CAMTA2;ACTA1;NPY1R;TRIP4

CBY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBY1.

FAM92A1; TTC23L; CFAP53; YWHAZ; CDK6; q81xy2_bacan; sbcC3; AGTPBP1; q9wmx2-pro_0000037548; YWHAE

Leo, E; Mancini, M; et al. DNA Methyltransferase 1 Drives Transcriptional Down-Modulation of beta Catenin Antagonist Chibby1 Associated With the BCR-ABL1 Gene of Chronic Myeloid Leukemia. JOURNAL OF CELLULAR BIOCHEMISTRY 116:589-597(2015).

Lee, YL; Sante, J; et al. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. MOLECULAR BIOLOGY OF THE CELL 25:2919-2933(2014).