cby1
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  • Official Full Name
  • chibby homolog 1 (Drosophila)
  • Background
  • Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A
Cat.#:CBY1-2720HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CBY1 Protein, MYC/DDK-tagged
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Cat.#:CBY1-5152HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CBY1 Protein, GST-tagged
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Cat.#:CBY1-596HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBY1 Protein, His-tagged
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Cat.#:Cby1-597MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cby1 Protein, His-tagged
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Cat.#:CBY1-5398CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CBY1
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Cat.#:CBY1-1129ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CBY1
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Cat.#:CBY1-147HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CBY1 lysate
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Involved Pathway

CBY1 involved in several pathways and played different roles in them. We selected most pathways CBY1 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBY1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Deactivation of the beta-catenin transactivating complex
SOX4A; SRY; SOX7; SOX32; C; RBBP5; TLE3B; CTBP1; BCL9; TLE2
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
KCNIP4; TLE4; CYR61; T; AES; IGF2BP1; CBY1; CDX4; TLE1; CDX1
Signal Transduction
MOB1BA; RGS10; FGD4A; RBP2A; TLE2; RARGA; ARHGEF1A; RTN4; MDK; SOX4A
Signaling by Wnt
PRICKLE1; CDC73; RBBP5; SOX4B; PYGO1; SOX4A; KLHL12; PRICKLE1B; LGR5; HECW1B
TCF dependent signaling in response to WNT
SOX4B; ZNRF3; HECW1; USP34; LGR5; CBY1; LGR4; RSPO3; WNT8-2; PYGO2

Protein Function

CBY1 has several biochemical functions, for example, beta-catenin binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBY1 itself. We selected most functions CBY1 had, and list some proteins which have the same functions with CBY1. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein PTPRK; PROP1; GLI3; CDH1; SLC9A3R2; CARM1; NF2; BCL9L; EP300; MED12
Function identical protein binding
Related Protein SH3GL3; SDF4; DYNLT1C; TTC32; ACADM; ATL1; TRIM8; TPRGL; PTS; CLDN4
Function protein binding
Related Protein TELO2; PNKD; BCAP31; LRFN2; S1PR2; SIRT1; LIMK2; RBMY1B; SERPINA5; PDZD7

Interacting Protein

CBY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBY1.
FAM92A1; TTC23L; CFAP53; YWHAZ; CDK6; q81xy2_bacan; sbcC3; AGTPBP1; q9wmx2-pro_0000037548; YWHAE

CBY1 Related Articles

Leo, E; Mancini, M; et al. DNA Methyltransferase 1 Drives Transcriptional Down-Modulation of beta Catenin Antagonist Chibby1 Associated With the BCR-ABL1 Gene of Chronic Myeloid Leukemia. JOURNAL OF CELLULAR BIOCHEMISTRY 116:589-597(2015).
Lee, YL; Sante, J; et al. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. MOLECULAR BIOLOGY OF THE CELL 25:2919-2933(2014).