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Official Full Name chibby homolog 1 (Drosophila)
Background Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CBY1-147HCL Recombinant Human CBY1 lysate HEK293 N/A
    Human CBY1-2720H Recombinant Human CBY1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CBY1-5152H Recombinant Human CBY1 Protein, GST-tagged Wheat Germ GST
    Human CBY1-596H Recombinant Human CBY1 Protein, His-tagged E.coli His
    Mouse Cby1-597M Recombinant Mouse Cby1 Protein, His-tagged E.coli N/A
    Chicken CBY1-5398C Recombinant Chicken CBY1 Mammalian Cell His
    Zebrafish CBY1-1129Z Recombinant Zebrafish CBY1 Mammalian Cell His

    CBY1 involved in several pathways and played different roles in them. We selected most pathways CBY1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Deactivation of the beta-catenin transactivating complex ASH2L; SOX13; SOX32; TLE2; RBBP5; CTBP1; BCL9L; TLE3; PYGO2; CBY1
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription CDX1; CBY1; MYOG; KRT1; TLE4; ZCCHC12; BCL9; HBP1; TCF4; T
    Signal Transduction CDC73; MYO7AA; PRC1; RHPN1; JUPA; EVC; TNKS2; HCAR1-2; PLEKHG2; GPR132B
    Signaling by Wnt PYGO2; DACT1; PYGO1; CSNK1G2; WIF1; CCDC88C; SOX7; KREMEN1; TNKS2; RNF43
    TCF dependent signaling in response to WNT RNF146; ASH2L; PYGO1; TNKS; TNKS2; RSPO4; C; CDC73; RSPO2; RYK

    CBY1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CBY1 itself. We selected most functions CBY1 had, and list some proteins which have the same functions with CBY1. You can find most of the proteins on our site.

    Function Related Protein
    beta-catenin binding NF2; DACT1; BTRC; AXIN2; SALL1; CTNNA3; TCF7L2; CD2AP; CALCOCO1; TBL1XR1
    identical protein binding GCG; ACTG1; BAK1; NONO; IFI16; GCC2; ETNPPL; B2M; SDK2; RUVBL2
    protein binding DDX21; MEX3C; HNF4A; KLKB1; CRHR2; NUDT1; SPTLC1; OLFM4; CAV1; SPRYD7

    CBY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBY1.

    FAM92A1; TTC23L; CFAP53; YWHAZ; CDK6; q81xy2_bacan; sbcC3; AGTPBP1; q9wmx2-pro_0000037548; YWHAE

    Leo, E; Mancini, M; et al. DNA Methyltransferase 1 Drives Transcriptional Down-Modulation of beta Catenin Antagonist Chibby1 Associated With the BCR-ABL1 Gene of Chronic Myeloid Leukemia. JOURNAL OF CELLULAR BIOCHEMISTRY 116:589-597(2015).
    Lee, YL; Sante, J; et al. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. MOLECULAR BIOLOGY OF THE CELL 25:2919-2933(2014).

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