CCL11

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CCL11

Official Full Name chemokine (C-C motif) ligand 11
Background Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.[5] The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.
Synonyms Ccl11; chemokine (C-C motif) ligand 11; Scya11; eotaxin; eotaxin-1; MGC22554; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); small inducible cytokine A11; C-C motif chemokine 11; Eosinophil chemotactic protein
    • Species :
    • Bovine
    • Cattle
    • Equine
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus Monkey
    • Sheep
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Biotin
    • Fc
    • GST
    • His
    • T7
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ccl11-128M Recombinant Mouse Ccl11 Protein E.coli
    Mouse Ccl11-1347M Recombinant Mouse Ccl11 Protein E. coli
    Rhesus CCL11-221R Recombinant Rhesus CCL11 protein E.coli N/A
    Human CCL11-3564H Recombinant Human CCL11 protein E.coli N/A
    Human CCL11-0606H Recombinant Human CCL11 Protein, GST-Tagged Wheat Germ GST
    Human CCL11-165H Recombinant Human CCL11, MIgG2a Fc-tagged CHO Fc
    Human CCL11-166H Recombinant Human CCL11, HIgG1 Fc-tagged, mutant CHO Fc
    Human CCL11-167H Recombinant Human CCL11, HIgG1 Fc-tagged CHO Fc
    Human CCL11-172H Recombinant Human CCL11 Human N/A
    Human CCL11-225H Recombinant Human CCL11 Protein, His-tagged E.coli His
    Human CCL11-27H Recombinant Human Chemokine (C-C motif) ligand 11,His-tagged E.coli His
    Human CCL11-289H Recombinant Human CCL11, StrepII-tagged Human Cell Strep II
    Human CCL11-595H Recombinant Human CCL11 protein, His & GST-tagged E.coli His/GST
    Human CCL11-622H Recombinant Human Chemokine (C-C motif) Ligand 11, His-tagged E.coli His
    Human CCL11-7735HCL Recombinant Human CCL11 293 Cell Lysate HEK293 N/A
    Human CCL11P-102H Human CCL11, Biotin-tagged Biotin
    Mouse Ccl11-1777M Recombinant Mouse Ccl11 protein, His & GST-tagged E.coli His/GST
    Mouse CCL11-37M Recombinant Mouse Chemokine (C-C Motif) Ligand 11 E.coli N/A
    Mouse Ccl11-4329M Recombinant Mouse Ccl11 Protein Yeast N/A
    Mouse Ccl11-620M Recombinant Mouse Ccl11 protein E.coli N/A
    Rat CCL11-1210R Recombinant Rat CCL11 Protein Mammalian Cell His
    Rat Ccl11-596R Recombinant Rat Ccl11 protein, His & GST-tagged E.coli His/GST
    Rat Ccl11-636R Recombinant Rat Ccl11 protein E.coli N/A
    Rhesus Monkey CCL11-1155R Recombinant Rhesus Monkey CCL11 Protein E.coli N/A
    Rhesus Macaque CCL11-679R Recombinant Rhesus monkey CCL11 Protein, His-tagged Mammalian Cell His
    Bovine CCL11-130B Recombinant Bovine Chemokine (C-C motif) Lligand 11 Yeast N/A
    Rabbit CCL11-4377R Recombinant Rabbit CCL11 Protein Yeast N/A
    Equine CCL11-138E Recombinant Equine CCL11 Yeast N/A
    Pig CCL11-149S Recombinant Swine CCL11 Yeast N/A
    Sheep CCL11-4345S Recombinant Sheep CCL11 Protein Yeast N/A
    Cattle CCL11-593C Recombinant Cattle CCL11 protein, His & T7-tagged E.coli His/T7
    Horse CCL11-594H Recombinant Horse CCL11 protein, His & GST-tagged E.coli His/GST

    CCL11 involved in several pathways and played different roles in them. We selected most pathways CCL11 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IFNA10; CXCR4B; IFNA8; TNFRSF21; ACVR1BA; M17; Ccl12; IL15; KIT; CXCL5
    Chemokine signaling pathway CCL4L1; CXCL1; CXCL13; CCL15; CCL26; GM2506; CCL21; CCR7; CCR10; CXCL12
    Asthma FCER1A; HLA-DQA1; IL4; CCL11; CD40; HLA-DPB1; HLA-DPA1; EPX; HLA-DRB4; HLA-DRB3

    CCL11 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL11 itself. We selected most functions CCL11 had, and list some proteins which have the same functions with CCL11. You can find most of the proteins on our site.

    Function Related Protein
    CCR chemokine receptor binding XCL1; CCL44; CCL34B.1; CCL14; CCL24; CCL8; CCL1; CCL20A.3; CX3CL1; CCL34A.4
    chemokine activity CCL7; Ccl21a; CCL8; CXCL12A; CCL6; CCL34B.1; CCL19A.2; CCL35.1; CXCL3; CCL26
    protein binding SMAP2; USP8; EIF2AK2; GSTA4; POLG2; RAB14; CCR1; FLNA; NDUFB9; U2AF2

    CCL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL11.

    DPP4; CCR3; NUDT3; TPI1

    Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
    Andreasen, A; Petersen, HH; et al. Immune and inflammatory responses in pigs infected with Trichuris suis and Oesophagostomum dentatum. VETERINARY PARASITOLOGY 207:249-258(2015).

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