ccl11
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  • Official Full Name
  • chemokine (C-C motif) ligand 11
  • Background
  • Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.[5] The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.
  • Synonyms
  • Ccl11; chemokine (C-C motif) ligand 11; Scya11; eotaxin; eotaxin-1; MGC22554; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); small inducible cytokine A11; C-C motif chemokine 11; Eosinophil chemotactic protein
Cat.#:CCL11-0606HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL11 Protein, GST-Tagged
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Cat.#:Ccl11-4329MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Ccl11 Protein
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Cat.#:CCL11-1155RTag:
Source (Host):E. coliSpecies:Rhesus Monkey
Product nameRecombinant Rhesus Monkey CCL11 Protein
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Cat.#:CCL11-4377RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit CCL11 Protein
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Cat.#:CCL11-4345STag:
Source (Host):YeastSpecies:Sheep
Product nameRecombinant Sheep CCL11 Protein
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Cat.#:CCL11-172HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL11
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Cat.#:CCL11-622HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) Ligand 11, His-tagged
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Cat.#:CCL11-27HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C motif) ligand 11,His-tagged
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Cat.#:CCL11-37MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-C Motif) Ligand 11
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Cat.#:CCL11-130BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Chemokine (C-C motif) Lligand 11
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Cat.#:CCL11-149STag:N/A
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine CCL11
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Cat.#:CCL11-165HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL11, MIgG2a Fc-tagged
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Cat.#:CCL11-166HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL11, HIgG1 Fc-tagged, mutant
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Cat.#:CCL11-167HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL11, HIgG1 Fc-tagged
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Cat.#:CCL11-225HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL11 Protein, His-tagged
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Cat.#:CCL11-289HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL11, StrepII-tagged
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Cat.#:CCL11-595HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL11 protein, His & GST-tagged
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Cat.#:CCL11P-102HTag:Biotin
Source (Host):Species:Human
Product nameHuman CCL11, Biotin-tagged
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Cat.#:Ccl11-1777MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl11 protein, His & GST-tagged
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Cat.#:Ccl11-620MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl11
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Cat.#:CCL11-1210RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCL11 Protein
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Cat.#:Ccl11-596RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl11 protein, His & GST-tagged
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Cat.#:Ccl11-636RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccl11
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Cat.#:CCL11-679RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCL11 Protein, His-tagged
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Cat.#:CCL11-138ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine CCL11
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Cat.#:CCL11-593CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CCL11 protein, His & T7-tagged
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Cat.#:CCL11-594HTag:His/GST
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse CCL11 protein, His & GST-tagged
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Cat.#:CCL11-7735HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCL11 293 Cell Lysate
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Involved Pathway

CCL11 involved in several pathways and played different roles in them. We selected most pathways CCL11 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNE; IL24; IFNA2; IFNK; INHBB; OSM; IL20RA; GH1; CNTF; IL6R
Chemokine signaling pathway
PTK2; HRAS; MAPK3; GNGT1; LOC100033925; NFKBIB; GNB4; AKT1; GNG10; SHC4
Asthma
HLA-DPA1; IL3; IL13; MS4A2; HLA-DPB1; HLA-DRA; HLA-DRB3; CD40; HLA-DOB; TNF

Protein Function

CCL11 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL11 itself. We selected most functions CCL11 had, and list some proteins which have the same functions with CCL11. You can find most of the proteins on our site.
Function
Related Protein
Function CCR chemokine receptor binding
Related Protein CCL25B; CCL1; CCL33.3; CCL44; CCL19B; XCL2; CCRL2; CCL24; CCL38A.4; CCL21
Function chemokine activity
Related Protein CCL20; CCL34B.9; CCL26; CXCL18B; CCL22; CCL13; CCL11; CCL33.3; CCL33.2; PF4V1
Function protein binding
Related Protein SUDS3; SPI1B; VAMP4; SHFM1; TCF7L2; ZMYND19; USE1; SSTR3; DNAJC28; FBXO17

Interacting Protein

CCL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL11.
DPP4; CCR3; NUDT3; TPI1

CCL11 Related Articles

Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
Andreasen, A; Petersen, HH; et al. Immune and inflammatory responses in pigs infected with Trichuris suis and Oesophagostomum dentatum. VETERINARY PARASITOLOGY 207:249-258(2015).

CCL11 Related Gene Family

GPCRs Chemokines Cytokines