cct5
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  • Official Full Name
  • chaperonin containing TCP1, subunit 5 (epsilon)
  • Background
  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex;(CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each;containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in;an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional;splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three;pseudogenes of this gene have been identified.
  • Synonyms
  • CCT5; chaperonin containing TCP1, subunit 5 (epsilon); T-complex protein 1 subunit epsilon; KIAA0098; T-complex protein 1, epsilon subunit; CCTE; CCT-epsilon; TCP-1-epsilon
Cat.#:CCT5-0714HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCT5 Protein, GST-Tagged
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Cat.#:CCT5-3014HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCT5 Protein, MYC/DDK-tagged
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Cat.#:CCT5-10898HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCT5, GST-tagged
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Cat.#:CCT5-27006THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCT5, His-tagged
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Cat.#:CCT5-3026MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCT5 Protein
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Cat.#:CCT5-1234RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCT5 Protein
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Cat.#:CCT5-383CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CCT5 Protein, His-tagged
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Cat.#:CCT5-714RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCT5 Protein, His-tagged
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Cat.#:CCT5-1935CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCT5
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Cat.#:CCT5-11892ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCT5
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Cat.#:CCT5-172HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCT5 lysate
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Involved Pathway

CCT5 involved in several pathways and played different roles in them. We selected most pathways CCT5 participated on our site, such as Assembly of the primary cilium, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the primary cilium
SDCCAG8; DYNLL2A; MAPRE1B; TRIP11; CCDC123; CCT4; CEP63; DYNLL2B; CEP78; MARK4
Association of TriC/CCT with target proteins during biosynthesis
KIFC3; FBXW5; TCP1; CCT7; CCT6A; CCT4; FBXW9; CCT2; FKBP9; CCT3
BBSome-mediated cargo-targeting to cilium
BBS9; SETD6; BBS2; TCP1; CCT2; MKKS; BBS10; SSTR3; CCT4; PROL1
Cargo trafficking to the periciliary membrane
PKD2; TTC8; EXOC1; CCT8; EXOC5; BBS9; CNGA5; CNGA2; UNC119.1; CCT2
Chaperonin-mediated protein folding
CCT3; FBXW5; TCP1; KIFC3; VBP1; NOP56; PFDN2; CCT4; CCT5; FBXL5
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
PFDN4; TUBB4A; CCT7; TUBB4B; PFDN2; CCT6A; CCT3; PFDN6; TCP1; CCT5
Folding of actin by CCT/TriC
CCT3; CCT5; CCT2; CCT4; CCT6A; CCT7; TCP1; CCT8
Formation of tubulin folding intermediates by CCT/TriC
TUBB4A; CCT6A; CCT3; TUBA3D; CCT2; CCT7; CCT5; TCP1; CCT8; TUBA1B

Protein Function

CCT5 has several biochemical functions, for example, ATP binding, G-protein beta-subunit binding, beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT5 itself. We selected most functions CCT5 had, and list some proteins which have the same functions with CCT5. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PSKH2; MAPK8; NME4; GUCY2C; DDX6; STK25; KIF2A; KIF3CB; CDKL5; NEK10
Function G-protein beta-subunit binding
Related Protein GNG13; CCT5; RGS7; F2RL1; RASD2; GNG2; F2R; RGS9; RGS11; OPRM1
Function beta-tubulin binding
Related Protein TRPV4; SPAST; MAP1S; RACGAP1; B4GALT1; ARL8B; PROL1; VAPB; HDAC6; LRPPRC
Function protein binding
Related Protein TTYH2; HIST1H2AG; TBX2A; PIP5K1C; PI4KB; GYPB; CENPP; REXO1L1; NPY2R; ZNF317
Function unfolded protein binding
Related Protein HSP90AA1; CRYAB; HSP90AA1.2; HSPA6; CCT7; GRPEL1; CCT2; PFDN4; DNAJB1B; SPG7

Interacting Protein

CCT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT5.
PPP4C; PPP2CB; PPP2CA; STRN3; ILK; TCP1; IKBKE; TP53