|Official Full Name||chaperonin containing TCP1, subunit 5 (epsilon)|
|Background||The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex;(CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each;containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in;an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional;splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three;pseudogenes of this gene have been identified.|
|Synonyms||CCT5; chaperonin containing TCP1, subunit 5 (epsilon); T-complex protein 1 subunit epsilon; KIAA0098; T-complex protein 1, epsilon subunit; CCTE; CCT-epsilon; TCP-1-epsilon|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CCT5 involved in several pathways and played different roles in them. We selected most pathways CCT5 participated on our site, such as Assembly of the primary cilium, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Assembly of the primary cilium||DCTN2; CEP89; MAPRE1B; IFT-20; KIFAP3B; EXOC3; RHOL; TTC30A2; TUBB4B; MAPRE1A|
|Association of TriC/CCT with target proteins during biosynthesis||CCT3; FKBP9; FBXW2; CCT7; KIFC3; FBXW5; TCP1; CCT5; FBXL5; FBXW4|
|BBSome-mediated cargo-targeting to cilium||BBS1; MKKS; PROL1; BBS2; LZTFL1; BBS10; TCP1; CCT4; BBS7; TTC8|
|Cargo trafficking to the periciliary membrane||SETD6; BBS9; ARL13B; BBS2; EXOC1; RP2; RAB3IP; CCT2; BBS10; BBS5|
|Chaperonin-mediated protein folding||NOP56; FBXW9; FBXL5; FBXW5; CCT2; PFDN2; TCP1; CCT7; KIFC3; VBP1|
|Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding||CCT3; CCT6A; TUBB4A; TCP1; TUBA3D; CCT5; PFDN5; TUBB4B; PFDN6; CCT2|
|Folding of actin by CCT/TriC||CCT2; CCT4; CCT3; CCT5; CCT6A; TCP1; CCT8; CCT7|
|Formation of tubulin folding intermediates by CCT/TriC||CCT5; CCT8; CCT6A; TUBA3D; CCT2; TUBB4A; TUBB4B; CCT7; TUBA1B; CCT3|
CCT5 has several biochemical functions, for example, ATP binding, G-protein beta-subunit binding, beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT5 itself. We selected most functions CCT5 had, and list some proteins which have the same functions with CCT5. You can find most of the proteins on our site.
|ATP binding||GLYCTK; MAPKAPK2A; WNK2; PTK7A; ACSL1; ACSM2; RIOK2; SMC6; DDX28; SMCHD1|
|G-protein beta-subunit binding||RGS11; F2R; RGS9; CCT5; GNG2; RGS7; F2RL1; GNG13; RASD2; OPRM1|
|beta-tubulin binding||RGS2; TRPV4; GABARAP; CASC1; GABARAPL1; GABARAPL2; NDEL1; SNCA; LRPPRC; VAPB|
|protein binding||NIPAL1; GFER; EXOSC10; POMP; MC1R; PARN; SUSD2; SPG20; HLA-DOA; DYNC1LI1|
|unfolded protein binding||TBCA; LRPAP1; NDUFAF1; DNAJB1B; TTC1; CCT8; HSP90B1; HSPA1A; HSP104; DNAJB1A|
CCT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT5.
PPP4C; PPP2CB; PPP2CA; STRN3; ILK; TCP1; IKBKE; TP53