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CCT5

  • Official Full Name

    chaperonin containing TCP1, subunit 5 (epsilon)

  • Overview

    The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex;(CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each;containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in;an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional;splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three;pseudogenes of this gene have been identified.
  • Synonyms

    CCT5; chaperonin containing TCP1, subunit 5 (epsilon); T-complex protein 1 subunit epsilon; KIAA0098; T-complex protein 1, epsilon subunit; CCTE; CCT-epsilon; TCP-1-epsilon;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCT5-27006TH Recombinant Human CCT5, His-tagged E.coli His
Human CCT5-10898H Recombinant Human CCT5, GST-tagged E.coli GST C-term-300a.a.
Human CCT5-0714H Recombinant Human CCT5 Protein, GST-Tagged Wheat Germ GST
Human CCT5-172HCL Recombinant Human CCT5 lysate HEK293 N/A
Human CCT5-001H Recombinant Human CCT5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human CCT5-529H Recombinant Human CCT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CCT5-3014H Recombinant Human CCT5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CCT5-529H-B Recombinant Human CCT5 Protein Pre-coupled Magnetic Beads HEK293
Human CCT5-109H Recombinant Human CCT5 protein, His-tagged E.coli His
Human CCT5-3043HF Recombinant Full Length Human CCT5 Protein, GST-tagged In Vitro Cell Free System GST 541 amino acids
Human CCT5-862HFL Recombinant Full Length Human CCT5 Protein, C-Flag-tagged Mammalian cells Flag
Mouse CCT5-3026M Recombinant Mouse CCT5 Protein Mammalian Cell His
Mouse CCT5-1429M Recombinant Mouse CCT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CCT5-1429M-B Recombinant Mouse CCT5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cct5-805M Recombinant Mouse Cct5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CCT5-1234R Recombinant Rat CCT5 Protein Mammalian Cell His
Rat CCT5-892R Recombinant Rat CCT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CCT5-892R-B Recombinant Rat CCT5 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CCT5-383C Recombinant Cynomolgus CCT5 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CCT5-131C Recombinant Cynomolgus Monkey CCT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CCT5-131C-B Recombinant Cynomolgus Monkey CCT5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CCT5-714R Recombinant Rhesus monkey CCT5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCT5-541R-B Recombinant Rhesus Macaque CCT5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CCT5-541R Recombinant Rhesus Macaque CCT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CCT5-11892Z Recombinant Zebrafish CCT5 Mammalian Cell His
Chicken CCT5-1935C Recombinant Chicken CCT5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CCT5 involved in several pathways and played different roles in them. We selected most pathways CCT5 participated on our site, such as Assembly of the primary cilium, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of the primary ciliumTRAF3IP1;B9D2;ARF4A;KIF17;CEP97;CSNK1D;TTC26;IFT74;FBF1
Association of TriC/CCT with target proteins during biosynthesisFBXW2;CCT3;FBXL5;CCT7;FKBP9;FBXW4;FBXW5;NOP56;CCT5
BBSome-mediated cargo-targeting to ciliumBBS4;TCP1;SSTR3;CCT2;CCT3;CCT5;TTC8;LZTFL1;MKKS
Cargo trafficking to the periciliary membraneCNGA2;LZTFL1;CCT4;CNGA5;BBS5;PROL1;ARF4;SETD6;CCT2
Chaperonin-mediated protein foldingFBXW9;FBXW4;CCT4;FBXW5;CCT2;TUBA3D;CCT8;CCT7;TCP1
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingTUBB4A;TUBB4B;TUBA3D;CCT5;CCT7;CCT6A;CCT4;PFDN2;VBP1
Folding of actin by CCT/TriCCCT2;CCT3;CCT7;CCT5;TCP1;CCT4;CCT8;CCT6A
Formation of tubulin folding intermediates by CCT/TriCCCT8;CCT7;CCT5;TUBB4A;CCT4;TUBB4B;TUBA1B;TCP1;TUBA3D

CCT5 has several biochemical functions, for example, ATP binding, G-protein beta-subunit binding, beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT5 itself. We selected most functions CCT5 had, and list some proteins which have the same functions with CCT5. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTARS;PGS1;UBE2T;ITGB1BP3;TRNT1;SARS2;GART;DAPK2A;KATNA1
G-protein beta-subunit bindingF2R;RASD2;F2RL1;OPRM1;CCT5;RGS9;RGS7;RGS11;GNG2
beta-tubulin bindingLRPPRC;PEX14;PROL1;PIFO;BBS4;SERPINB1A;PDCD5;NDEL1;SPAST
protein bindingFNDC3B;C1orf21;PAGE1;DHX40;PPP2R1B;CCND3;NIP7;CST2;PRDX6
unfolded protein bindingDNAJB2;AFG3L2;NAP1L4;CCT4;HSPE1;DNAJA1;HSPA1A;PFDN5;SSUH2.2

CCT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT5.

PPP4C; PPP2CB; PPP2CA; STRN3; ILK; TCP1; IKBKE; TP53

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