cd226
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  • Official Full Name
  • CD226 antigen
  • Background
  • DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-s
  • Synonyms
  • CD226; CD226 antigen; platelet and T cell activation antigen 1; platelet and T-cell activation antigen 1; Pta1; DNAM1; DNAM-1; TLiSA1; BC051526
Cat.#:CD226-248CATag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD226 protein, Fc-tagged, APC labeled
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Cat.#:CD226-248CPTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD226 protein, Fc-tagged, R-PE labeled
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Cat.#:CD226-395HTag:His|Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 Protein (Met1-Asn247), His-Fc-tagged, Biotinylated
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Cat.#:CD226-634HATag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 protein, Fc-His-tagged, APC labeled
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Cat.#:CD226-634HPTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 protein, Fc-His-tagged, R-PE labeled
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Cat.#:CD226-635HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 protein, Fc-tagged, APC labeled
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Cat.#:CD226-635HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 protein, Fc-tagged, R-PE labeled
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Cat.#:Cd226-635MATag:Fc|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd226 protein, Fc-His-tagged, APC labeled
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Cat.#:Cd226-635MPTag:Fc|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd226 protein, Fc-His-tagged, R-PE labeled
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Cat.#:Cd226-8794RATag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd226 protein, Fc-tagged, APC labeled
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Cat.#:Cd226-8794RPTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd226 protein, Fc-tagged, R-PE labeled
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Cat.#:CD226-0750HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD226 Protein, GST-Tagged
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Cat.#:CD226-3056HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 Protein, MYC/DDK-tagged
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Cat.#:CD226-318CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD226 protein, His-tagged
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Cat.#:CD226-139HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD226 protein, T7/His-tagged
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Cat.#:CD226-2190HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226, His tagged
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Cat.#:CD226-229HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 protein, His-tagged
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Cat.#:CD226-634HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226, Fc-His tagged
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Cat.#:CD226-635HTag:human|IgG1|Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 protein, Fc-tagged
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Cat.#:CD226-636HTag:Avi|Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 Protein, Fc & Avi-tagged, Biotinylated
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Cat.#:CD226-7254HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD226, His-tagged
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Cat.#:Cd226-2274MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd226, His tagged
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Cat.#:Cd226-635MTag:Fc|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd226, Fc-His tagged
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Cat.#:Cd226-1105RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd226 Protein, His-tagged
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Cat.#:Cd226-8794RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd226, Fc tagged
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Cat.#:CD226-248CTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD226 protein, Fc-tagged
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Cat.#:CD226-1607RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CD226 Protein
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Cat.#:CD226-1608RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CD226 Protein, hIgG1-tagged
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Cat.#:CD226-1609RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CD226 Protein, hIgG4-tagged
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Cat.#:CD226-729RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD226 Protein, His-tagged
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Cat.#:CD226-5128ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CD226
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Cat.#:CD226-1603HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human CD226 Molecule
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Cat.#:CD226-2645HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD226 cell lysate
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Cat.#:CD226-2800MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD226 cell lysate
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Cat.#:CD226-1173RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD226 cell lysate
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Cat.#:CD226-1167CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD226 cell lysate
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Involved Pathway

CD226 involved in several pathways and played different roles in them. We selected most pathways CD226 participated on our site, such as Adaptive Immune System, Cell adhesion molecules (CAMs), Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD226 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
SH3RF1; KLHL21; RNF14; B2ML; FRS2; MAPKAP1; RAP1GAP2B; CD96; KIR2DS2; RNF34
Cell adhesion molecules (CAMs)
CLDN18; NRXN3; NLGN4X; NRCAM; VTCN1; CLDN10; CLDN7A; PVR; ITGAV; JAM2A
Immune System
ADAR; LTF; IRF6; SIGLEC15; TRAF7; UBE2E3; AP1S3A; UBR1; CR1; ARIH1L
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
PVRL2L; KLRB1F; TREML2; CD300LB; RAET1E; CD200; SIGLEC9; LILRB2; CD200R3; CD96

Protein Function

CD226 has several biochemical functions, for example, cell adhesion molecule binding, integrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD226 itself. We selected most functions CD226 had, and list some proteins which have the same functions with CD226. You can find most of the proteins on our site.
Function
Related Protein
Function cell adhesion molecule binding
Related Protein PVRL1; CADM1B; MSN; VCAM1; NLGN4Y; NLGN2; TIGIT; CADM1A; LPHN1; CADM3
Function integrin binding
Related Protein ACTN3; DST; SFRP2; ICAM4; TIMP2; NF2; PPAP2B; THY1; ADAMTS13; WISP2
Function protein binding
Related Protein GAGE1; DCAF7; ANKRD49; ARHGAP5; LAPTM4B; ZNF473; FLT3; FOXK2; GPAA1; ASS1
Function protein homodimerization activity
Related Protein TERF1; ADD2; SYT10; KCNN2; IKZF4; GABRR1; NR4A2; NOG; UGT1A1; TIMM10
Function protein kinase binding
Related Protein CAMK2N2; PTK2; NGFRAP1; PRC1; ADIPOR1; AP1B1; CCNK; MAPK8IP2; GATA6; GRIN2A
Function receptor activity
Related Protein TIGIT; RAMP3; VMN1R48; TEK; PVRL4; CMKLR1; VMN1R41; VMN1R54; NLGN4Y; TNFRSF11B

Interacting Protein

CD226 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD226 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD226.
TIGIT; PVR; PVRL2

CD226 Related Articles

Johnston, RJ; Comps-Agrar, L; et al. The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function. CANCER CELL 26:923-937(2014).
Hou, SK; Ge, KK; et al. CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular Domain. JOURNAL OF BIOLOGICAL CHEMISTRY 289:6969-6977(2014).