cdh2
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  • Official Full Name
  • cadherin 2, type 1, N-cadherin (neuronal)
  • Background
  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CDH2; cadherin 2, type 1, N-cadherin (neuronal); CDHN; NCAD; CD325; CDw325; cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal;
Cat.#:CDH2-0983HTag:His-Flag-StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CDH2 Protein, His-Flag-StrepII-Tagged
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Cat.#:CDH2-0984HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDH2 Protein, GST-Tagged
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Cat.#:CDH2-3153HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH2 Protein, MYC/DDK-tagged
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Cat.#:CDH2-2191HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH2, His tagged
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Cat.#:CDH2-271HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDH2 Protein, His-tagged
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Cat.#:CDH2-28769THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CDH2
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Cat.#:CDH2-315HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH2, His-Fc tagged
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Cat.#:CDH2-316HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human CDH2, Fc tagged
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Cat.#:CDH2-4938HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDH2 protein, GST-tagged
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Cat.#:CDH2-7023HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDH2 protein, His-tagged
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Cat.#:CDH2-87HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cadherin 2, Type 1, N-cadherin (Neuronal)
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Cat.#:CDH2-304MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cdh2, LEVLFQ tagged
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Cat.#:Cdh2-592MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Cdh2 Protein, Fc Chimera
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Cat.#:Cdh2-7024MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdh2 protein, His-tagged
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Cat.#:CDH2-1290RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDH2 Protein
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Cat.#:Cdh2-7025RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cdh2 protein, His-tagged
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Cat.#:Cdh2-7026RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cdh2 protein, His-tagged
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Cat.#:Cdh2-8757RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cdh2, His tagged
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Cat.#:CDH2-1740RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH2 Protein
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Cat.#:CDH2-1741RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH2 Protein, hIgG1-tagged
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Cat.#:CDH2-1742RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey CDH2 Protein, hIgG4-tagged
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Cat.#:CDH2-1134CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDH2
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Cat.#:CDH2-8707ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDH2
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Cat.#:CDH2-980HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH2 cell lysate
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Cat.#:CDH2-971MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CDH2 cell lysate
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Involved Pathway

CDH2 involved in several pathways and played different roles in them. We selected most pathways CDH2 participated on our site, such as Adherens junctions interactions, Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junctions interactions
CDH3; CDH6; CADM2; CADM2A; CDH7; CTNNB1; CDH8; JUPA; PVRL1A; CTNNA1
Arrhythmogenic right ventricular cardiomyopathy
DSC2; DAG1; CTNNA1; DSP; CTNNA2; CACNG2; DMD; DSG2; JUP; DES
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
CACNB1; ITGB6; ITGA6; LEF1; ITGA8; ITGA10; AASS; CACNB4; DSP; CACNG8
BDNF signaling pathway
EGR2; GRIP1; CNR1; CDK5; CDH2; KCNN2; EEF2; EGR1; CDKL5; BCL2L11
CDO in myogenesis
TCF3A; SPAG9; TCF3B; MYOG; CTNNA1; BNIP2; MYF6; CDON; MEF2B; CTNNA2
Cell adhesion molecules (CAMs)
HLA-E; NLGN2B; CLDN3; Icosl; JAM2; CLDNK; CD276; NCAM1B; CLDNG; HLA-DQA1
Cell junction organization
CDH12; CDH2; FBLIM1; CDH5; CDH11; PARVB; CDH24; CDH13; CD151; CDH4
Cell-Cell communication
DSCAM; CDH9; KIRRELB; PVRL2L; CLDN7; CDH2; PLECA; FERMT2; CDH24; CADM2A

Protein Function

CDH2 has several biochemical functions, for example, alpha-catenin binding, beta-catenin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH2 itself. We selected most functions CDH2 had, and list some proteins which have the same functions with CDH2. You can find most of the proteins on our site.
Function
Related Protein
Function alpha-catenin binding
Related Protein NUMB; VCL; CDH24; PKP2; PKP3; CDH2; JUB; JUP; AJUBA; CTNNB1
Function beta-catenin binding
Related Protein NF2; SLC9A3R1; GSK3B; VCL; SOX17; SOX9; PTPRK; CDH2; BCL9L; SALL1
Function calcium ion binding
Related Protein SWAP70B; PLS1; EFCAB4A; ANXA6; PROS1; GRM7; MYL13; PPP3R2; CALRL2; SYT5B
Function gamma-catenin binding
Related Protein DSG1; APC; PTPRK; TCF7L2; CDH2; FER; PTPRJ; CTNNA1; CDH1; APC2
Function nitric-oxide synthase binding
Related Protein DNM2; SLC6A4; CAMK2D; CALM1; SNTA1; DNM3; SCN5A; ACTB; NOS1AP; ATP2B4
Function protein binding
Related Protein BDKRB1; NCOR1; NME2; MPZL2; GYPB; TLE2; CBX5; NCS1; GPSM1; SEPSECS
Function protein complex binding
Related Protein SHARPIN; FGFR1; RANBP2; TAPBPL; ARRB2; CAV3; FADD; KCTD5; CDKN1A; PCSK2
Function protein kinase binding
Related Protein DPYSL2; CALM3; MAPK4; DBF4B; RELA; TP53; CACNB2; GCSAM; HDAC7; CCNL1A
Function protein phosphatase binding
Related Protein DRD1; SKAP1; CSF1R; VCAN; ANAPC5; KAT2A; JUPA; CDH2; TRP53; EGFR

Interacting Protein

CDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH2.
CTNNB1; PTPRC; PTPRB; PTPRG; PTPN6; PTPN7; PTPN12; PTPRJ; PTPRR; PTPRK; PTPRO; PTPN22; CTNND1; PRKAR1A; JUP; EXOC5