cdk5
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  • Official Full Name
  • CDK5 cyclin-dependent kinase 5
  • Background
  • Cyclin dependent kinase 5 (CdK5) is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
  • Synonyms
  • Cyclin cdk5; CDK5; cyclin-dependent kinase 5; PSSALRE; OTTHUMP00000212917; OTTHUMP00000212939; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; Cyclin dependent kinase 5
Cat.#:CDK5/SNAP25-276HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK5/SNAP25, GST-tagged, Active
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Cat.#:CDK5-1018HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDK5 Protein, GST-Tagged
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Cat.#:CDK5-1021HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK5 Protein, GST-Tagged
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Cat.#:CDK5-236HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CDK5 Protein, His-tagged
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Cat.#:CDK5-186HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CDK5
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Cat.#:CDK5-27906THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK5
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Cat.#:CDK5-382HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CDK5&p35 protein, GST-tagged
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Cat.#:CDK5-396HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human cyclin-dependent kinase 5, His-tagged
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Cat.#:CDK5-829HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK5 protein, His & S-tagged
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Cat.#:CDK5-965HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK5, GST tagged
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Cat.#:CDK5-3204MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDK5 Protein
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Cat.#:CDK5-1305RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDK5 Protein
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Cat.#:CDK5-785RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDK5 Protein, His-tagged
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Cat.#:CDK5-3877CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDK5
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Cat.#:CDK5-9240ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK5
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Cat.#:CDK5-1001HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 5, GST-tagged
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Cat.#:CDK5-815HTag:gst
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK5, GST-tagged
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Cat.#:CDK5-7626HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CDK5 293 Cell Lysate
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Involved Pathway

CDK5 involved in several pathways and played different roles in them. We selected most pathways CDK5 participated on our site, such as Alzheimers disease, Axon guidance, BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
PLCB1; PPP3R1; NDUFV2; EIF2AK3; GAPDH; ATP5G3; CASP9; ATP5O; PSEN1; UQCRFS1
Axon guidance
EGF; UNC5A; JAK3; KDR; SLIT1; L1CAM; DPYSL5A; RASGEF1A; COL6A3; LRRC4
BDNF signaling pathway
SIRPA; CDH2; BCL2L11; CNR1; MAP3K2; CSNK2A1; KCNN2; GRIP1; CFL1; YBX1
CRMPs in Sema3A signaling
CRMP1; SEMA3A; DPYSL2B; NRP1A; DPYSL5B; SEMA3AB; DPYSL2; DPYSL3; DPYSL4; SEMA3AA
Cocaine addiction
RGS9; SLC18A1; RELA; GPSM1; GRIN3B; CDK5R1; GNAI3; CREB3L1; ATF4; GRIN2A
DARPP-32 events
CDK5; PRKAR1AA
DNA damage response
CDK5; GADD45A; GADD45G; HUS1B; TLK2; CHEK2; DDB2; RAD17; RAD9A; RAD1

Protein Function

CDK5 has several biochemical functions, for example, ATP binding, ErbB-2 class receptor binding, ErbB-3 class receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5 itself. We selected most functions CDK5 had, and list some proteins which have the same functions with CDK5. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein OASL2; SRMS; ACTA1B; DHX58; PSMC6; MYO1G; PGK2; ATP2C2; MCM2; LCK
Function ErbB-2 class receptor binding
Related Protein MUC4; NRG1; CDK5
Function ErbB-3 class receptor binding
Related Protein PIK3R1; NRG1; CDK5; ERBB2
Function acetylcholine receptor activator activity
Related Protein CDK5
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein CDK5R1; CDK9; MOK; CDKL2; CDK4; CDKL5; CDKL1; PFTK1; CDK16; NAT1
Function cytoskeletal protein binding
Related Protein EZRA; PACSIN1A; CAPN10; PACSIN3; MYLIP; CDK5; EPB41L3A; TNNT2A; LDB3; PACSIN1
Function ephrin receptor binding
Related Protein EFNB2A; NTRK1; SIPA1L1; CHN1; EFNB2B; EFNA3B; ANKS1B; EFNA1; PIK3CG; SRC
Function kinase activity
Related Protein DCLK2; ACVR1L; EPHA4A; PAK2A; BMPR1BB; ROCK2A; PRKACAA; SMOK2B; CCL3; PRKCBP1L
Function p53 binding
Related Protein ZNF385C; RNF20; TAF1; BCL2L12; PLK3; ZNF385A; CDKN2AIP; EP300; ZFP385C; RNF34
Function protein binding
Related Protein RABAC1; PTPLAD1; LINC00482; N6AMT1; PIH1D2; PPIB; PATL1; SHC1; LRP5; RRM2
Function protein kinase activity
Related Protein CDK11A; PHKG1B; RPS6KA5; RPS6KB2; GUCY2C; CAMKK1B; OXSR1B; CSNK1G2B; VSIG8B; PRKCD
Function protein kinase binding
Related Protein LSM2; AKAP5; CASP9; FAF1; PRDX3; CAMK2N1; SLC12A4; CACNB2; SV2A; CCNYL1
Function protein serine/threonine kinase activity
Related Protein TGFBR1; BRAF; NEK10; ROCK2B; RPS6KA5; PIM3; CAMKK1A; DCLK3; ULK4; CDK15
Function tau-protein kinase activity
Related Protein GSK3B; PRKAA1; CSNK1D; PHKG1; MARK1; MARK4; PHKG2; MARK2; CDK5; GSK3A

Interacting Protein

CDK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5.
CDKN1B; CCND2; CABLES1; CDKN1A

CDK5 Related Articles

Olah, Z; Kalman, J; et al. Proteomic Analysis of Cerebrospinal Fluid in Alzheimer's Disease: Wanted Dead or Alive. JOURNAL OF ALZHEIMERS DISEASE 44:1303-1312(2015).
Vazquez-Rosa, E; Rodriguez-Cruz, EN; et al. Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity. PROTEIN SCIENCE 23:1197-1207(2014).