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Official Full Name CDK5 cyclin-dependent kinase 5
Background Cyclin dependent kinase 5 (CdK5) is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
Synonyms Cyclin cdk5; CDK5; cyclin-dependent kinase 5; PSSALRE; OTTHUMP00000212917; OTTHUMP00000212939; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; Cyclin dependent kinase 5
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • S
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDK5-4483H Recombinant Human CDK5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Cdk5-866M Recombinant Mouse Cdk5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CDK5/SNAP25-276H Recombinant Human CDK5/SNAP25, GST-tagged, Active Sf9 Insect Cell GST
    Human CDK5-1001H Recombinant Human Cyclin-Dependent Kinase 5, GST-tagged E.coli GST
    Human CDK5-1018H Recombinant Human CDK5 Protein, GST-Tagged Wheat Germ GST
    Human CDK5-1021H Recombinant Human CDK5 Protein, GST-Tagged Insect Cell GST
    Human CDK5-186H Recombinant Human CDK5 Mammalian Cell His
    Human CDK5-236H Recombinant Human CDK5 Protein, His-tagged Insect Cell His
    Human CDK5-27906TH Recombinant Human CDK5 E.coli N/A
    Human CDK5-382H Recombinant Human CDK5&p35 protein, GST-tagged Insect Cell GST
    Human CDK5-396H Recombinant Human cyclin-dependent kinase 5, His-tagged E.coli His
    Human CDK5-7626HCL Recombinant Human CDK5 293 Cell Lysate HEK293 N/A
    Human CDK5-815H Recombinant Human CDK5, GST-tagged Human gst
    Human CDK5-829H Recombinant Human CDK5 protein, His & S-tagged E.coli His/S
    Human CDK5-965H Recombinant Human CDK5, GST tagged Insect Cell GST
    Mouse CDK5-3204M Recombinant Mouse CDK5 Protein Mammalian Cell His
    Rat CDK5-1305R Recombinant Rat CDK5 Protein Mammalian Cell His
    Rhesus Macaque CDK5-785R Recombinant Rhesus monkey CDK5 Protein, His-tagged Mammalian Cell His
    Chicken CDK5-3877C Recombinant Chicken CDK5 Mammalian Cell His
    Zebrafish CDK5-9240Z Recombinant Zebrafish CDK5 Mammalian Cell His

    CDK5 involved in several pathways and played different roles in them. We selected most pathways CDK5 participated on our site, such as Alzheimers disease, Axon guidance, BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease PPP3R2; CASP8; NDUFA3; NDUFA13; NDUFS4; CAPN1; UQCRQ; GRIN2B; ATP5H; UQCR10
    Axon guidance NRG3; RNF8; PLXND1; L1CAM; NTN1B; NRG2A; CXCR4; PTK2; PLXNA1; SEMA4B
    BDNF signaling pathway GRIP1; SYN1; GNB2L1; EIF4EBP1; CFL1; SIRPA; DOK5; CDKL5; EEF2; MAP3K2
    Cocaine addiction GRIN3A; CDK5; CREB3L2; CREB3L4; GPSM1; GRIN2B; CREB3L3; GNAI3; NFKB1; GNAI1
    DARPP-32 events PRKAR1AA; CDK5
    DNA damage response HUS1B; RAD1; RAD17; GADD45G; DDB2; GADD45A; CHEK2; TLK2; CDK5; RAD9A

    CDK5 has several biochemical functions, for example, ATP binding, ErbB-2 class receptor binding, ErbB-3 class receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5 itself. We selected most functions CDK5 had, and list some proteins which have the same functions with CDK5. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding AURKB; GRK7B; PRKDC; SYN2; NME2B.2; MAP3K9; FIGNL1; GM7168; DDX55; DYRK1AA
    ErbB-2 class receptor binding CDK5; MUC4; NRG1
    ErbB-3 class receptor binding PIK3R1; ERBB2; NRG1; CDK5
    acetylcholine receptor activator activity CDK5
    cyclin-dependent protein serine/threonine kinase activity CDK3; CDK11B; CDK1; CDK19; CCNK; CDK5; CCND3; CDK14; PFTK1; CDKL2
    cytoskeletal protein binding Fert2; MSNB; LIN7C; CAPN10; EPB41L3A; PACSIN1A; FLNC; CAPN2; MYPN; EPB41L4A
    ephrin receptor binding PTPN1; EFNA5; EFNA1B; EPHA4; EFNB2B; EFNA1A; CBL; EPHA7; CHN1; EFNA3B
    kinase activity GSK3AB; LRGUK; ERBB3B; EPHB2B; CAMK1DB; PLK2B; PTK2AA; PKM2; NR5A1B; Aatk
    p53 binding CDKN2AIP; EHMT2; BRD4; ZNF385A; TP73; SETD7; ZMAT4; RCHY1; TRIM29; BLM
    protein binding SLC2A4; KIF1B; CD300LG; WDR34; TMPRSS2; HIST1H2AI; EIF4A1; ZNF434; MTAP; MAP3K8
    protein kinase activity RAF1; PRKACAA; MKNK2A; FASTKD3; CDK12; CAMKK1A; MAP3K2; SGK2A; GRK7A; IRAK1
    protein kinase binding CCNL1; CCNB3; NEK6; NEFH; SPRED2; ELP2; PRDX3; DNAJA3; CDKN2B; TSACC
    protein serine/threonine kinase activity TTK; PRKCDA; GRK1B; MOK; TTBK2; PBK; PIM1; MAPK8B; ULK3; DAPK3
    tau-protein kinase activity GSK3A; MARK4; CDK5; MARK1; MARK2; PHKG1; PHKG2; GSK3B; CSNK1D; PRKAA1

    CDK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5.


    Olah, Z; Kalman, J; et al. Proteomic Analysis of Cerebrospinal Fluid in Alzheimer's Disease: Wanted Dead or Alive. JOURNAL OF ALZHEIMERS DISEASE 44:1303-1312(2015).
    Vazquez-Rosa, E; Rodriguez-Cruz, EN; et al. Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity. PROTEIN SCIENCE 23:1197-1207(2014).

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