cdk7
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  • Official Full Name
  • cyclin-dependent kinase 7
  • Background
  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
  • Synonyms
  • CAK1; MO15; STK1; CDKN7; p39MO15; CDK7; cyclin-dependent kinase 7; CAK; p39 Mo15; 39 KDa protein kinase; Cdk-activating kinase; kinase subunit of CAK; serine/threonine kinase stk1; cell division protein kinase 7; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; TFIIH basal transcription factor complex kinase subunit; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
Cat.#:CDK7/CCNH/MNAT1-279HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK7/CCNH/MNAT1, His-tagged, Active
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Cat.#:CDK7-1033HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDK7 Protein, GST-Tagged
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Cat.#:CDK7-1035HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK7 Protein, GST-His-Tagged
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Cat.#:CDK7-1036HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK7 Protein, GST-Tagged
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Cat.#:CDK7-31757THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human CDK7, His-tagged
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Cat.#:CDK7-568HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CDK7
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Cat.#:Cdk7-1925MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdk7 protein, His-tagged
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Cat.#:CDK7-3211MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDK7 Protein
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Cat.#:CDK7-789RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDK7 Protein, His-tagged
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Cat.#:CDK7-12210ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK7
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Cat.#:CDK7-1151HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 7, His-tagged
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Cat.#:CDK7-1539HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK7, Unactive, GST-tagged
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Cat.#:CDK7 & CCNH & MNAT1-539HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK7 & CCNH & MNAT1 cell lysate
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Cat.#:CDK7-7621HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDK7 293 Cell Lysate
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Involved Pathway

CDK7 involved in several pathways and played different roles in them. We selected most pathways CDK7 participated on our site, such as B Cell Receptor Signaling Pathway, Basal transcription factors, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
B Cell Receptor Signaling Pathway
BANK1; LIME1; RAC1; INPPL1; PILRB; BTK; IKBKB; MAP2K2; PLEKHA1; DUSP6
Basal transcription factors
TBPL1; GTF2F2A; GTF2B; TAF15; GTF2H1; ERCC2; CDK7; TAF1; TAF7; TAF12
Cell Cycle
SMC1A; MND1; CDKN2D; NEDD1; RBBP7; PIANP; GADD45BA; TUBG2; SFN; BRE
Cell Cycle, Mitotic
DBF4; MLF1IP; CKS1B; HIST4H4; NDC80; CDK7; APITD1; CENPP; SSNA1; HIST2H3C
Cyclin A/B1 associated events during G2/M transition
CDK7; FOXM1
Cyclin A:Cdk2-associated events at S phase entry
MYCA; CDK7; CKS1B
Cyclin D associated events in G1
CDK7; PIANP; CKS1B; CDKN2B; E2F4; CDKN2D; CDKN2C

Protein Function

CDK7 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK7 itself. We selected most functions CDK7 had, and list some proteins which have the same functions with CDK7. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein EGFRA; ATP1A1; AURKA; ATAD3A; DNAH11; ATP7A; IQCA1; TSSK5; ACTR2; CSNK1G2A
Function DNA-dependent ATPase activity
Related Protein TTF2; RAD51B; MSH3; MSH4; RAD51L1; XRCC3; ERCC2; IGHMBP2; CHD8; RAD51D
Function RNA polymerase II carboxy-terminal domain kinase activity
Related Protein CDK1; CDK7; CDK13; MAPK1; CDK9; CDK8; CCNK; CDK12
Function androgen receptor binding
Related Protein KDM1A; DAXX; CDK7; NRIP1; KAT5; KDM4C; RNF14; PRMT2; RAN; TCF21
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein CDK1; CDK17; CDK5; CDKL1; CDK4; CDKL2; CCNK; ICK; CDK13; CDKL5
Function protein C-terminus binding
Related Protein YWHAQ; PIAS4; PXK; CORO1A; ARL6IP5; PPP1R9B; IFT52; DLG3; OPRL1; RABAC1
Function protein binding
Related Protein ESYT2; C2orf57; LC3; OTULIN; IQUB; TLE3; PBXIP1; THEMIS2; CUL2; OIP5
Function protein kinase activity
Related Protein EPHA4; MOK; DYRK1A; CDK7; PRKCHA; DCLK1A; CDK5; LMTK2; KALRN; AVP
Function transcription coactivator activity
Related Protein NACA; SMARCD1; CTBP2; CEBPA; TUBB3; CITED4; PMF1; NFATC4; RBPMS; GTF2F1

Interacting Protein

CDK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK7.
CCNH; MNAT1; GTF2H5; Dlg4; SRPK2; SRPK1; HSP90AB1; E2F1; HLA-DQA1

CDK7 Related Articles

Caro-Astorga, J; Fajardo, I; et al. Nascent histamine induces alpha-synuclein and caspase-3 on human cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 451:580-586(2014).
Phinyo, M; Nounurai, P; et al. Characterization and expression analysis of Cyclin-dependent kinase 7 gene and protein in ovaries of the giant tiger shrimp Penaeus monodon. AQUACULTURE 432:286-294(2014).