cdkn2b
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  • Official Full Name
  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • Background
  • This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); P15; MTS2; TP15; CDK4I; INK4B; p15INK4b; cyclin-dependent kinase 4 inhibitor B; MTS-2; p14-INK4b; p14_INK4B; p15-INK4b; p15_INK4B; CDK4B inhibitor; p14_CDK inhibitor; p15 CDK inhibitor; CDK inhibitory protein; multiple tumor suppressor 2; cyclin-dependent kinases 4 and 6 binding protein;
Cat.#:CDKN2B-1064HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDKN2B Protein, GST-Tagged
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Cat.#:CDKN2B-11063HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN2B, GST-tagged
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Cat.#:CDKN2B-134HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN2B protein, His-tagged
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Cat.#:CDKN2B-32HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CDKN2B protein
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Cat.#:Cdkn2b-1253MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdkn2b protein, His & T7-tagged
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Cat.#:CDKN2B-3226MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDKN2B Protein
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Cat.#:CDKN2B-1316RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDKN2B Protein
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Cat.#:CDKN2B-6003CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDKN2B
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Cat.#:CDKN2B-7613HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDKN2B 293 Cell Lysate
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Involved Pathway

CDKN2B involved in several pathways and played different roles in them. We selected most pathways CDKN2B participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
CEP290; CCND2A; CEP70; TERF1; CENPC1; CDK5RAP2; RAD9B; NCAPG2; NDE1; MIS12
Cell Cycle, Mitotic
NEK7; NCAPD2; ANKLE2; NIPBL; CTDNEP1A; NDEL1A; CNEP1R1; TUBG2; INCENP; FGFR1OP
Cellular Senescence
HIRA; ASF1A; POT1; PHC1; BMI1A; HMGA1-RS1; IGFBP7; EP400; SUZ12A; HIST4H4
Cellular responses to stress
PTGES3; IGFBP7; ERF; CDKN2B; POT1; EEF1A1; PRDX2; RING1; CBX8B; DYNLL2A
Cyclin D associated events in G1
CDK7; CDKN2B; PIANP; E2F4; CDKN2D; CKS1B; CDKN2C
FoxO signaling pathway
MAPK13; G6PC3; PRKAB1; SMAD2; HOMER1; PRKAB2; MAPK3; PLK2; SOD2; G6PCA.1
G1 Phase
E2F4; CKS1B; CDKN2C; CDKN2D; PIANP; CDKN2B

Protein Function

CDKN2B has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2B itself. We selected most functions CDKN2B had, and list some proteins which have the same functions with CDKN2B. You can find most of the proteins on our site.
Function
Related Protein
Function cyclin-dependent protein serine/threonine kinase inhibitor activity
Related Protein CDKN2C; CDKN1BA; CDKN1BB; HEXIM1; CDKN2D; HEXIM2; CDKN1D; CDKN2A; Casp3; INCA1
Function protein binding
Related Protein POLH; CYC1; RECQL; MS4A12; C18orf1; POT1; AMBRA1; APOA1BP; PTBP3; AUP1
Function protein kinase binding
Related Protein PFKFB2; CDKN2D; TRAF2; PTPRR; FGF19; DCX; BAG5; CHEK2; ACVRL1; CACNB2

Interacting Protein

CDKN2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2B here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2B.
CDK4; CDK6; 80125; TRAF1