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CFTR

  • Official Full Name

    cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

  • Overview

    CFTR (ABC35, ABCC7, CBAVD, CF, dj760C5.1, MRP7, TNR-CFTR) is a member of the ATP-binding cassette (ABC) transporter superfamily. Mutations in ABC genes have been linked to many diseases. CFTR is a plasma membrane cyclic AMP activated chloride channel that
  • Synonyms

    CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); ABCC7, CF, cystic fibrosis transmembrane conductance regulator, ATP binding cassette (sub family C, member 7); cystic fibrosis transmembrane conducta;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Mammalian cell
  • Mammalian Cell
  • Wheat Germ
  • C
  • StrepII
  • 10×His
  • eGFP, Strep II,10His
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CFTR-275H Recombinant Human CFTR protein, GST-tagged E.coli GST
Human CFTR-1181H Recombinant Human CFTR Protein, GST-Tagged Wheat Germ GST
Human CFTR-27241TH Recombinant Human CFTR Wheat Germ N/A 100 amino acids
Human CFTR-592H Recombinant Human CFTR Mammalian Cell His
Human CFTR-1780H Recombinant Human CFTR protein, His & GST-tagged E.coli His/GST Met1~Gly330
Human CFTR-12H Recombinant Human CFTR Protein (Pro1181-End), N-His-tagged E.coli N-His Pro1181-End
Human CFTR-2664H Recombinant Human CFTR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CFTR-276H Recombinant Human CFTR protein, GST-tagged E. coli GST 1210-1480 aa
Human CFTR-0456H Recombinant Human CFTR Protein (M1-L1480 end), eGFP, Strep II, 10×His tagged Mammalian cell eGFP, Strep II,10His M1-L1480 end
Human CFTR-2664H-B Recombinant Human CFTR Protein Pre-coupled Magnetic Beads HEK293
Human CFTR-277H Recombinant Human CFTR protein, His-tagged E. coli His 1210-1480 aa
Human CFTR-278H Recombinant Human CFTR protein, His-tagged E. coli His 1-80 aa
Human CFTR-1187HFL Recombinant Human CFTR protein, His&Flag-tagged HEK293 His&Flag 1-1480 aa
Human CFTR-10H Recombinant Human CFTR-3C-eGFP Protein (M1-L1480 end), C-StrepII/10×His-tagged Mammalian cell C-StrepII/10×His M1-L1480 end
Mouse CFTR-3354M Recombinant Mouse CFTR Protein Mammalian Cell His
Mouse CFTR-1616M Recombinant Mouse CFTR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CFTR-1616M-B Recombinant Mouse CFTR Protein Pre-coupled Magnetic Beads HEK293
Rat CFTR-1357R Recombinant Rat CFTR Protein Mammalian Cell His
Rat CFTR-1015R-B Recombinant Rat CFTR Protein Pre-coupled Magnetic Beads HEK293
Rat CFTR-1015R Recombinant Rat CFTR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CFTR-830R Recombinant Rhesus monkey CFTR Protein, His-tagged Mammalian Cell His
Rhesus Macaque CFTR-656R Recombinant Rhesus Macaque CFTR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CFTR-656R-B Recombinant Rhesus Macaque CFTR Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CFTR-3993Z Recombinant Zebrafish CFTR Mammalian Cell His
Chicken CFTR-3753C Recombinant Chicken CFTR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CFTR Related Articles

CFTR involved in several pathways and played different roles in them. We selected most pathways CFTR participated on our site, such as ABC transporter disorders, ABC transporters, ABC-family proteins mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFTR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC transporter disorders
ABC transportersSUR2A;ABCA8;ABCA6;ABCC5;TAP2;ABCG5;ABCB9;ABCA3;TAP1
ABC-family proteins mediated transportABCA7;KCNJ11;ABCC2;ABCG4B;ABCB8;ABCE1;EIF2S1A;ABCC9;CFTR
AMPK signaling pathwaySTRADA;IGF1;PPP2R1A;CREB3L3;EEF2;INS1;FBP1;CFTR;PRKAB2
Bile secretionCA2;ADCY7;ADCY3;ATP1B4;OSTA;SLC5A1;AQP1;SLC2A1;SCTR
Defective CFTR causes cystic fibrosis
DiseaseACAN;CFTR;AP1B1;AP1S1;RBP4;RCC1;OPN1SW;GYG1;AP2M1
Disorders of transmembrane transportersCFTR;GCKR

CFTR has several biochemical functions, for example, ATP binding, ATP-binding and phosphorylation-dependent chloride channel activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFTR itself. We selected most functions CFTR had, and list some proteins which have the same functions with CFTR. You can find most of the proteins on our site.

Function Related Protein
ATP bindingABCA1;HELZ2;TTLL13;YARS;DDX21;P2RX6;RAD51L1;UCKL1;RIPK1L
ATP-binding and phosphorylation-dependent chloride channel activity
PDZ domain bindingSRR;DOCK4;SLC22A12;FZD8;SDC2;GRID2;DLC;ARHGEF16;GJA1
bicarbonate transmembrane transporter activitySLC26A11;SLC4A1B;SLC4A1;SLC26A9;SLC26A3.2;SLC4A11;SLC26A6;SLC26A7;SLC26A1
channel-conductance-controlling ATPase activity
chloride channel activityGABRR1;GABRG1;CLIC1;TTYH2L;TTYH3B;GABRA3;APOL1;GABRP;SLC26A11
chloride channel inhibitor activityWNK1;STX7;VTI1B;CFTR;STX8;STX1A;VAMP8
chloride transmembrane transporter activitySLC26A3;SLC26A1;Slc4a2;SLC26A6;CFTR;SLC26A4;SLC4A1
enzyme bindingRPS2;HDAC6;YWHAH;STUB1;BRCA1;SCARB2;PYCARD;TP53;PAWR
protein bindingLOXL3;MYOC;C1GALT1C1;ING5;FAM164A;NXT1;TGFB3;2610109H07Rik;STX3

CFTR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFTR here. Most of them are supplied by our site. Hope this information will be useful for your research of CFTR.

SLC9A3R1; SLC9A3R2; CANX; PPP2R1A

Palomo, J; Marchiol, T; et al. Role of IL-1 beta in Experimental Cystic Fibrosis upon P. aeruginosa Infection. PLOS ONE 9:-(2014).
Pruliere-Escabasse, V; et al. Rhinitis investigations in children: When and how to investigate. REVUE FRANCAISE D ALLERGOLOGIE 54:566-569(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is there any gene therapy or medications targeting CFTR protein for CF treatment? 10/22/2022

Yes, there are medications like Ivacaftor, Lumacaftor, and Tezacaftor that target specific CFTR mutations to improve CFTR function. Gene therapy approaches are also being developed.

Are there different types of CFTR mutations, and do they have varying clinical implications? 03/13/2021

Yes, there are various types of CFTR mutations, some of which are associated with milder or more severe forms of CF, depending on the specific mutation.

Are there ongoing clinical trials and research related to CFTR protein and CF treatment? 02/11/2021

Yes, there are numerous clinical trials and research studies focusing on CFTR-targeted therapies and novel approaches for treating cystic fibrosis.

Can CFTR protein-related therapies benefit individuals with non-CF conditions? 07/18/2019

Yes, some CFTR-targeted therapies may have potential applications in conditions involving mucus secretion, like chronic bronchitis and bronchiectasis.

What are the current clinical treatments for CF patients related to CFTR protein dysfunction? 02/04/2019

Current treatments aim to alleviate symptoms and improve the quality of life for CF patients, including therapies to reduce mucus thickness, antibiotics for lung infections, and airway clearance techniques.

Customer Reviews (3)

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Reviews
12/25/2020

    the CFTR protein's exceptional quality, coupled with the manufacturer's outstanding technical support, ensures that it fulfills my experimental needs with utmost precision and efficacy.

    05/08/2019

      the CFTR protein is an exceptional tool for investigating the intricate mechanisms and pathogenesis of amyloid-related diseases.

      01/09/2016

        Their collaboration during trial design and data analysis enhances the reliability and significance of my research findings.

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