CFTR
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Official Full Name
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
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Overview
CFTR (ABC35, ABCC7, CBAVD, CF, dj760C5.1, MRP7, TNR-CFTR) is a member of the ATP-binding cassette (ABC) transporter superfamily. Mutations in ABC genes have been linked to many diseases. CFTR is a plasma membrane cyclic AMP activated chloride channel that -
Synonyms
CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); ABCC7, CF, cystic fibrosis transmembrane conductance regulator, ATP binding cassette (sub family C, member 7); cystic fibrosis transmembrane conducta;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- Mammalian cell
- Mammalian Cell
- Wheat Germ
- C
- StrepII
- 10×His
- eGFP, Strep II,10His
- GST
- His
- His (Fc)
- Avi
- Flag
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CFTR Related Articles
CFTR involved in several pathways and played different roles in them. We selected most pathways CFTR participated on our site, such as ABC transporter disorders, ABC transporters, ABC-family proteins mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFTR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ABC transporter disorders | |
ABC transporters | SUR2A;ABCA8;ABCA6;ABCC5;TAP2;ABCG5;ABCB9;ABCA3;TAP1 |
ABC-family proteins mediated transport | ABCA7;KCNJ11;ABCC2;ABCG4B;ABCB8;ABCE1;EIF2S1A;ABCC9;CFTR |
AMPK signaling pathway | STRADA;IGF1;PPP2R1A;CREB3L3;EEF2;INS1;FBP1;CFTR;PRKAB2 |
Bile secretion | CA2;ADCY7;ADCY3;ATP1B4;OSTA;SLC5A1;AQP1;SLC2A1;SCTR |
Defective CFTR causes cystic fibrosis | |
Disease | ACAN;CFTR;AP1B1;AP1S1;RBP4;RCC1;OPN1SW;GYG1;AP2M1 |
Disorders of transmembrane transporters | CFTR;GCKR |
CFTR has several biochemical functions, for example, ATP binding, ATP-binding and phosphorylation-dependent chloride channel activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFTR itself. We selected most functions CFTR had, and list some proteins which have the same functions with CFTR. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | ABCA1;HELZ2;TTLL13;YARS;DDX21;P2RX6;RAD51L1;UCKL1;RIPK1L |
ATP-binding and phosphorylation-dependent chloride channel activity | |
PDZ domain binding | SRR;DOCK4;SLC22A12;FZD8;SDC2;GRID2;DLC;ARHGEF16;GJA1 |
bicarbonate transmembrane transporter activity | SLC26A11;SLC4A1B;SLC4A1;SLC26A9;SLC26A3.2;SLC4A11;SLC26A6;SLC26A7;SLC26A1 |
channel-conductance-controlling ATPase activity | |
chloride channel activity | GABRR1;GABRG1;CLIC1;TTYH2L;TTYH3B;GABRA3;APOL1;GABRP;SLC26A11 |
chloride channel inhibitor activity | WNK1;STX7;VTI1B;CFTR;STX8;STX1A;VAMP8 |
chloride transmembrane transporter activity | SLC26A3;SLC26A1;Slc4a2;SLC26A6;CFTR;SLC26A4;SLC4A1 |
enzyme binding | RPS2;HDAC6;YWHAH;STUB1;BRCA1;SCARB2;PYCARD;TP53;PAWR |
protein binding | LOXL3;MYOC;C1GALT1C1;ING5;FAM164A;NXT1;TGFB3;2610109H07Rik;STX3 |
CFTR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFTR here. Most of them are supplied by our site. Hope this information will be useful for your research of CFTR.
SLC9A3R1; SLC9A3R2; CANX; PPP2R1A
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are medications like Ivacaftor, Lumacaftor, and Tezacaftor that target specific CFTR mutations to improve CFTR function. Gene therapy approaches are also being developed.
Yes, there are various types of CFTR mutations, some of which are associated with milder or more severe forms of CF, depending on the specific mutation.
Yes, there are numerous clinical trials and research studies focusing on CFTR-targeted therapies and novel approaches for treating cystic fibrosis.
Yes, some CFTR-targeted therapies may have potential applications in conditions involving mucus secretion, like chronic bronchitis and bronchiectasis.
Current treatments aim to alleviate symptoms and improve the quality of life for CF patients, including therapies to reduce mucus thickness, antibiotics for lung infections, and airway clearance techniques.
Customer Reviews (3)
Write a reviewthe CFTR protein's exceptional quality, coupled with the manufacturer's outstanding technical support, ensures that it fulfills my experimental needs with utmost precision and efficacy.
the CFTR protein is an exceptional tool for investigating the intricate mechanisms and pathogenesis of amyloid-related diseases.
Their collaboration during trial design and data analysis enhances the reliability and significance of my research findings.
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