Recombinant Human CFTR protein, GST-tagged
Cat.No. : | CFTR-275H |
Product Overview : | Recombinant Human CFTR fused with GST tag was expressed in E. coli. |
Availability | November 05, 2024 |
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Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 20 mM Tris-HCl, 0.15 M NaCl, pH 8.0 |
AA Sequence : | MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPE MLKMFEDRLCHKTYLNGDHVTHPDF MLYDALDVVLYMDPMCLDAFPKLVC FKKRIEAIPQIDKYLKSSKYIAWPL QGWQATFGGGDHPPKSDLVPRGSYQ IIRRTLKQAFADCTVILCEHRIEAM L ECQQFLVIEENKVRQYDSIQKLLNE RSLFRQAISPSDRVKLFPHRNSSKC KSKPQIAALKEETEEEVQDTRL |
Storage : | For long term storage, prepare aliquots and store at -20 ~ -80 centigrade. Avoid freeze/thaw cycles. |
Publication : |
Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity (2017)
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Gene Name : | CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) [ Homo sapiens ] |
Official Symbol : | CFTR |
Synonyms : | CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); ABCC7, CF, cystic fibrosis transmembrane conductance regulator, ATP binding cassette (sub family C, member 7); cystic fibrosis transmembrane conductance regulator; ABC35; ATP binding cassette sub family C; member 7; CFTR/MRP; dJ760C5.1; MRP7; TNR CFTR; cAMP-dependent chloride channel; channel conductance-controlling ATPase; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; CF; ABCC7; TNR-CFTR; |
Gene ID : | 1080 |
mRNA Refseq : | NM_000492 |
Protein Refseq : | NP_000483 |
MIM : | 602421 |
UniProt ID : | P13569 |
Chromosome Location : | 7q31-q32 |
Pathway : | ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; ABC-family proteins mediated transport, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Gastric acid secretion, organism-specific biosystem; Gastric acid secretion, conserved biosystem; |
Function : | ATP binding; ATP-binding and phosphorylation-dependent chloride channel activity; ATPase activity; PDZ domain binding; channel-conductance-controlling ATPase activity; chloride channel activity; enzyme binding; hydrolase activity; ion channel activity; nucleotide binding; protein binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewthe CFTR protein's exceptional quality, coupled with the manufacturer's outstanding technical support, ensures that it fulfills my experimental needs with utmost precision and efficacy.
the CFTR protein is an exceptional tool for investigating the intricate mechanisms and pathogenesis of amyloid-related diseases.
Their collaboration during trial design and data analysis enhances the reliability and significance of my research findings.
Q&As (5)
Ask a questionYes, there are medications like Ivacaftor, Lumacaftor, and Tezacaftor that target specific CFTR mutations to improve CFTR function. Gene therapy approaches are also being developed.
Yes, there are various types of CFTR mutations, some of which are associated with milder or more severe forms of CF, depending on the specific mutation.
Yes, there are numerous clinical trials and research studies focusing on CFTR-targeted therapies and novel approaches for treating cystic fibrosis.
Yes, some CFTR-targeted therapies may have potential applications in conditions involving mucus secretion, like chronic bronchitis and bronchiectasis.
Current treatments aim to alleviate symptoms and improve the quality of life for CF patients, including therapies to reduce mucus thickness, antibiotics for lung infections, and airway clearance techniques.
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