Recombinant Human CFTR protein, His&Flag-tagged
Cat.No. : | CFTR-1187HFL |
Product Overview : | Recombinant Full Length Human CFTR protein(NP_000483)(1-1480 aa), fused with His and Flag tag, was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | His&Flag |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS, pH7.4 with 10% glycerin as protectant. |
Protein length : | 1-1480 aa |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied; 1 month, 2 to 8 °C under sterile conditions after reconstitution; 3 months, -20 to -70 °C under sterile conditions after reconstitution. |
Reconstitution : | It is recommended to reconstitute the lyophilized powder in sterile water to 100-200 ug/ml, and further dilute with other solvents.It can be stored at 4°C for 2-7 days and should be used up as soon as possible. If not in use for a short time, please store at -20°C. |
Gene Name : | CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) [ Homo sapiens ] |
Official Symbol : | CFTR |
Synonyms : | CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); ABCC7, CF, cystic fibrosis transmembrane conductance regulator, ATP binding cassette (sub family C, member 7); cystic fibrosis transmembrane conductance regulator; ABC35; ATP binding cassette sub family C; member 7; CFTR/MRP; dJ760C5.1; MRP7; TNR CFTR; cAMP-dependent chloride channel; channel conductance-controlling ATPase; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; CF; ABCC7; TNR-CFTR; |
Gene ID : | 1080 |
mRNA Refseq : | NM_000492 |
Protein Refseq : | NP_000483 |
MIM : | 602421 |
UniProt ID : | P13569 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewthe CFTR protein's exceptional quality, coupled with the manufacturer's outstanding technical support, ensures that it fulfills my experimental needs with utmost precision and efficacy.
the CFTR protein is an exceptional tool for investigating the intricate mechanisms and pathogenesis of amyloid-related diseases.
Their collaboration during trial design and data analysis enhances the reliability and significance of my research findings.
Q&As (5)
Ask a questionYes, there are medications like Ivacaftor, Lumacaftor, and Tezacaftor that target specific CFTR mutations to improve CFTR function. Gene therapy approaches are also being developed.
Yes, there are various types of CFTR mutations, some of which are associated with milder or more severe forms of CF, depending on the specific mutation.
Yes, there are numerous clinical trials and research studies focusing on CFTR-targeted therapies and novel approaches for treating cystic fibrosis.
Yes, some CFTR-targeted therapies may have potential applications in conditions involving mucus secretion, like chronic bronchitis and bronchiectasis.
Current treatments aim to alleviate symptoms and improve the quality of life for CF patients, including therapies to reduce mucus thickness, antibiotics for lung infections, and airway clearance techniques.
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