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  • Official Full Name
  • choline O-acetyltransferase
  • Background
  • Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.
  • Synonyms
  • CHAT; choline O-acetyltransferase; CHOACTase; choline acetylase; choline acetyltransferase;
Cat.#:Chat-1836RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Choline O-Acetyltransferase
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Cat.#:CHAT-172HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CHAT protein, His-tagged
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Cat.#:CHAT-174HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CHAT
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Cat.#:CHAT-175HCLTag:MYC/DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human CHAT HEK293T cell lysate
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Cat.#:CHAT-176HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHAT protein, GST-tagged
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Cat.#:CHAT-177HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHAT protein, GST-tagged
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Cat.#:CHAT-6178CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CHAT
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Involved Pathway

CHAT involved in several pathways and played different roles in them. We selected most pathways CHAT participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Acetylcholine Synthesis, Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHAT were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Acetylcholine Neurotransmitter Release Cycle
CCDC167; PPFIA4; PPFIA1; RERG; SNAP25A; SLC18A3A; RAB3AA; CPLX1; STXBP1A; CHAT
Acetylcholine Synthesis
PEMT; CHKA; CHAT
Biogenic Amine Synthesis
CHAT; COMT; DDC; DBH
Cholinergic synapse
CHAT; PIK3CG; CHRM1; PLCB1; AKT1; GNG8; KCNJ3; GNG10; PIK3R2; CHRNB4
Glycerophospholipid biosynthesis
PITPNB; AGPAT2; PHOSPHO1; AGPAT6; PLBD1; AGPAT1; CHAT; SLC44A5B; PNPLA8; PLB1
Glycerophospholipid metabolism
DGKQ; GPCPD1; LYCAT; CDS1; PLA2G12B; LPCAT3; PTDSS1; PLA2G4AA; GNPAT; PCYT1BA
Metabolism
GRHL1; ACER1; OSBP; AK7; SLC25A20; AKR1C6; EBP; LSM1; GSTO2; SLC5A2
Metabolism of lipids and lipoproteins
FABP1B.1; APOEB; PPARGC1B; MED9; PPM1LB; ALOX5B.2; CETP; CYP27B1; PIK3R6; ALOX5AP

Protein Function

CHAT has several biochemical functions, for example, choline O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHAT itself. We selected most functions CHAT had, and list some proteins which have the same functions with CHAT. You can find most of the proteins on our site.
Function
Related Protein
Function choline O-acetyltransferase activity
Related Protein CHATA; CHAT

CHAT Related Articles

Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
Wang, L; Ennis, M; et al. Characteristics of GABAergic and cholinergic neurons in perinuclear zone of mouse supraoptic nucleus. JOURNAL OF NEUROPHYSIOLOGY 113:754-767(2015).