| Official Full Name | choline O-acetyltransferase |
| Background | Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. |
| Synonyms | CHAT; choline O-acetyltransferase; CHOACTase; choline acetylase; choline acetyltransferase; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
CHAT involved in several pathways and played different roles in them. We selected most pathways CHAT participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Acetylcholine Synthesis, Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acetylcholine Neurotransmitter Release Cycle | SNAP25B; SYT1A; UNC13B; CPLX2L; PPFIA4; CHAT; CPLX1; SNAP25A; PPFIA2; RERG |
| Acetylcholine Synthesis | CHKA; CHAT; PEMT |
| Biogenic Amine Synthesis | COMT; CHAT; DBH; DDC |
| Cholinergic synapse | AKT2; CAMK2A; CREB3L3; BCL2; PRKACG; PIK3R1; PIK3R5; GNAI1; PIK3CG; GNB4 |
| Glycerophospholipid biosynthesis | PNPLA8; SLC44A5B; PLBD1; PLD4; CEPT1A; AGPAT2; CDIPT; CHKB; ABHD3; GPAT2 |
| Glycerophospholipid metabolism | PLA2G2A; PCYT2; GPAT2; DGKAA; PLA2G10; CDIPT; PLD1; PLD3; PTDSS1A; PLA2G12A |
| Metabolism | PDPR; UCP3; SLC26A2; SLC16A8; SLC5A4; BCHE; NUDT10; CDK19; CPNE6; HELZ2 |
| Metabolism of lipids and lipoproteins | CERS4A; ANKRD1; MED15; CHKA; PEMT; MED23; ARSJ; MED31; ACOT9.1; ARSI |
CHAT has several biochemical functions, for example, choline O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHAT itself. We selected most functions CHAT had, and list some proteins which have the same functions with CHAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| choline O-acetyltransferase activity | CHAT; CHATA |
CHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of CHAT.
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