CHAT
-
Official Full Name
choline O-acetyltransferase
-
Overview
Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. -
Synonyms
CHAT; choline O-acetyltransferase; CHOACTase; choline acetylase; choline acetyltransferase;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CHAT-176H | Recombinant Human CHAT protein, GST-tagged | Wheat Germ | GST | 1 a.a. - 630 a.a. | |
Human | CHAT-172H | Recombinant Human CHAT protein, His-tagged | E.coli | His | Asp517~Pro732 | |
Human | CHAT-174H | Recombinant Human CHAT | Mammalian Cell | His | ||
Human | CHAT-177H | Recombinant Human CHAT protein, GST-tagged | Wheat Germ | GST | 649 a.a. - 748 a.a. | |
Human | CHAT-175HCL | Recombinant Human CHAT HEK293T cell lysate | HEK293T | Myc/DDK | ||
Human | CHAT-2666H-B | Recombinant Human CHAT Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | CHAT-1021H | Recombinant Human CHAT Protein (Met1-Pro630), N-His tagged | E.coli | N-His | Met1-Pro630 | |
Human | CHAT-2464H | Recombinant Human CHAT protein, His-tagged | E.coli | His | 399-748 aa | |
Human | CHAT-1357H | Recombinant Human CHAT protein, His-tagged | E.coli | His | 120-733aa | |
Human | CHAT-2666H | Recombinant Human CHAT Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | CHAT-1359H | Recombinant Human CHAT protein, His&Myc-tagged | E.coli | His&Myc | 120-733aa | |
Rat | Chat-1836R | Recombinant Rat Choline O-Acetyltransferase | E.coli | N/A | ||
Chicken | CHAT-6178C | Recombinant Chicken CHAT | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CHAT Related Articles
- CHAT Related Research Area
CHAT involved in several pathways and played different roles in them. We selected most pathways CHAT participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Acetylcholine Synthesis, Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Acetylcholine Neurotransmitter Release Cycle | RAB3AB;RAB3AA;RERG;SLC18A3A;CHAT;PPFIA4;CPLX2L;PPFIA1;PPFIA2 |
Acetylcholine Synthesis | CHAT;PEMT;CHKA |
Biogenic Amine Synthesis | DDC;CHAT;COMT;DBH |
Cholinergic synapse | KCNQ1;GNAQ;GNG5;CAMK4;KCNQ2;PIK3R2;AKT1;GNA11;PIK3R5 |
Glycerophospholipid biosynthesis | PNPLA8;PITPNB;CPNE6;GPAT2;CEPT1;AGPAT1;CEPT1A;AWAT1;CHKA |
Glycerophospholipid metabolism | PLA2G5;GPD1;GPCPD1;MBOAT1;GPD1B;STIL;PGS1;CHKA;PCYT1AB |
Metabolism | CYP4F12;NUDT3;SULT1B1;CPT2;LBR;ARL2;CPOX;SUMF2;NUBP1 |
Metabolism of lipids and lipoproteins | GDF1;CETP;CYP2R1;APOA4B.2;ACOT13;COL4A3BP;CYP2AD2;CPNE6;PLIN2 |
CHAT has several biochemical functions, for example, choline O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHAT itself. We selected most functions CHAT had, and list some proteins which have the same functions with CHAT. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
choline O-acetyltransferase activity | CHATA;CHAT |
CHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of CHAT.
- Q&As
- Reviews
Q&As (6)
Ask a questionThe activity of the CHAT protein can be modulated by drugs or other small molecule compounds to treat neurological disorders associated with CHAT protein abnormalities. For example, some drugs can promote the expression and activity of the CHAT protein, thereby increasing acetylcholine synthesis.
Expression level of CHAT protein is regulated by a variety of factors, including gene expression, post-transcriptional modifications, nutritional status, etc. Some drugs or other small molecule compounds can also affect their expression levels by regulating gene expression or post-transcriptional modifications.
Some studies have shown that mutations or abnormal expression of the CHAT protein may be related to neurological diseases, psychiatric diseases, etc. However, further research is needed to confirm the association.
CHAT protein has some association with other neurotransmitters or signaling molecules. For example, it can interact with cholinergic neurons to co-regulate acetylcholine synthesis and release. In addition, it can interact with other neurotransmitters or signaling molecules such as dopamine, glutamate, etc.
The occurrence, progression and prognosis of neurological diseases can be assessed by detecting characteristics such as the expression level, activity and interaction of CHAT protein with other proteins. These features can also be used to develop new biomarkers and drug targets.
Some studies have shown that abnormal expression of CHAT protein may be related to the occurrence and progression of some neurological diseases, such as Alzheimer's disease and Parkinson's disease. In addition, the CHAT protein may also be a drug target for the treatment of these diseases.
Customer Reviews (3)
Write a reviewThe resolution of CHAT in Western blot is high and can distinguish between similar protein molecular weights.
This repeatability of CHAT is very good, which can greatly reduce the experimental error and allow me to evaluate the experimental results more accurately.
Stability of CHAT is so good that a variety of experimental manipulations can be performed without concern for changes and effects on its properties.
Ask a Question for All CHAT Products
Required fields are marked with *
My Review for All CHAT Products
Required fields are marked with *