CHAT Protein, choline O-acetyltransferase


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Official Full Name choline O-acetyltransferase
Background Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.
Synonyms CHAT; choline O-acetyltransferase; CHOACTase; choline acetylase; choline acetyltransferase;
    • Species :
    • Chicken
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHAT-172H Recombinant Human CHAT protein, His-tagged E.coli His
    Human CHAT-174H Recombinant Human CHAT Mammalian Cell His
    Human CHAT-175HCL Recombinant Human CHAT HEK293T cell lysate HEK293T Myc/DDK
    Human CHAT-176H Recombinant Human CHAT protein, GST-tagged Wheat Germ GST
    Human CHAT-177H Recombinant Human CHAT protein, GST-tagged Wheat Germ GST
    Rat Chat-1836R Recombinant Rat Choline O-Acetyltransferase E.coli N/A
    Chicken CHAT-6178C Recombinant Chicken CHAT Mammalian Cell His

    CHAT involved in several pathways and played different roles in them. We selected most pathways CHAT participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Acetylcholine Synthesis, Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Acetylcholine Neurotransmitter Release Cycle SNAP25B; SYT1A; UNC13B; CPLX2L; PPFIA4; CHAT; CPLX1; SNAP25A; PPFIA2; RERG
    Acetylcholine Synthesis CHKA; CHAT; PEMT
    Biogenic Amine Synthesis COMT; CHAT; DBH; DDC
    Cholinergic synapse AKT2; CAMK2A; CREB3L3; BCL2; PRKACG; PIK3R1; PIK3R5; GNAI1; PIK3CG; GNB4
    Glycerophospholipid biosynthesis PNPLA8; SLC44A5B; PLBD1; PLD4; CEPT1A; AGPAT2; CDIPT; CHKB; ABHD3; GPAT2
    Glycerophospholipid metabolism PLA2G2A; PCYT2; GPAT2; DGKAA; PLA2G10; CDIPT; PLD1; PLD3; PTDSS1A; PLA2G12A
    Metabolism PDPR; UCP3; SLC26A2; SLC16A8; SLC5A4; BCHE; NUDT10; CDK19; CPNE6; HELZ2
    Metabolism of lipids and lipoproteins CERS4A; ANKRD1; MED15; CHKA; PEMT; MED23; ARSJ; MED31; ACOT9.1; ARSI

    CHAT has several biochemical functions, for example, choline O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHAT itself. We selected most functions CHAT had, and list some proteins which have the same functions with CHAT. You can find most of the proteins on our site.

    Function Related Protein
    choline O-acetyltransferase activity CHAT; CHATA

    CHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of CHAT.

    Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
    Wang, L; Ennis, M; et al. Characteristics of GABAergic and cholinergic neurons in perinuclear zone of mouse supraoptic nucleus. JOURNAL OF NEUROPHYSIOLOGY 113:754-767(2015).

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