clic2
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  • Official Full Name
  • chloride intracellular channel 2
  • Background
  • Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue.This gene maps to the candidate region on chromosome X for incontinentia pigmenti.
  • Synonyms
  • CLIC2; chloride intracellular channel 2; chloride intracellular channel protein 2; XAP121; CLIC 2b; CLIC2_HUMAN; CLIC2b; OTTHUMP00000196471; XAP 121; OTTHUMP00000024248
Cat.#:CLIC2-1478HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLIC2 Protein, GST-tagged
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Cat.#:CLIC2-27815THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLIC2, His-tagged
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Cat.#:CLIC2-27817THTag:
Source (Host):Species:Human
Product nameRecombinant Human CLIC2
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Cat.#:CLIC2-3512HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chloride Intracellular Channel 2, His-tagged
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Cat.#:CLIC2-1449RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CLIC2 Protein
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Cat.#:CLIC2-909RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CLIC2 Protein, His-tagged
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Cat.#:CLIC2-2786CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CLIC2
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Cat.#:CLIC2-682ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CLIC2
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Cat.#:CLIC2-7447HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CLIC2 293 Cell Lysate
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Involved Pathway

CLIC2 involved in several pathways and played different roles in them. We selected most pathways CLIC2 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
FXYD6; FXYD7; CLCN5; ATP13A5; ASPH; ANO7; CLCN1A; SLC17A3; ATP8B1; TTYH2
Stimuli-sensing channels
TRPC4B; ASPH; FKBP1B; TPCN1; CLCN5; ASIC1A; MCOLN3; ANO7; TTYH3B; TRPM1
Transmembrane transport of small molecules
ABCA4A; MRS2; ATP1A1A.4; TRPC4AP; ABCB8; SLC35A2; AQP1A.1; BEST3; SCNN1D; SLC30A8

Protein Function

CLIC2 has several biochemical functions, for example, chloride channel activity, glutathione peroxidase activity, NOT glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIC2 itself. We selected most functions CLIC2 had, and list some proteins which have the same functions with CLIC2. You can find most of the proteins on our site.
Function
Related Protein
Function chloride channel activity
Related Protein GABRG2; SLC26A3.2; CLCN1; GABRA1; SLC26A6L; GABRP; SLC26A7; CLIC3; TTYH2L; FXYD3
Function glutathione peroxidase activity
Related Protein GSTK1; GPX1A; GPX1; GPX6; GPX4A; GPX4; MGST3; GPX7; GSTT1; GPX5
Function NOT glutathione transferase activity
Related Protein CLIC3; CLIC1; CLIC2; CLIC5; ALOX5AP
Function protein binding
Related Protein C4BPA; ZBTB43; KRT38; C14orf135; TGFB1I1; THOC4; EPHB2; DTX3; FCGR1A; MPZL2
Function voltage-gated ion channel activity
Related Protein KCNA2B; KCNJ1B; CACNG1A; GPR89; KCNV2; KCNC1B; KCNC3B; CLIC5B; CACNG8A; KCNV2B

Interacting Protein

CLIC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIC2.
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