cnot6
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  • Official Full Name
  • CCR4-NOT transcription complex, subunit 6
  • Background
  • The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3-5 RNase activity and prefers polyadenylated substates.
  • Synonyms
  • CNOT6; CCR4-NOT transcription complex, subunit 6; CCR4-NOT transcription complex subunit 6; CCR4; KIAA1194; fa03c11; wu:fc17f01; zgc:65822; A230103N10Rik; AA407540; AW456442; carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4 carbon catabolite repression 4 like; CCR4 carbon catabolite repression 4-like; Cytoplasmic deadenylase; EC 3.1.-.-; fc17f01; MGC98472; OTTHUMP00000161544; wu:fa03c11
Cat.#:CNOT6-1584HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CNOT6 Protein, GST-tagged
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Cat.#:CNOT6-3668MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CNOT6 Protein
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Cat.#:CNOT6-1495RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CNOT6 Protein
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Cat.#:CNOT6-939RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CNOT6 Protein, His-tagged
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Cat.#:CNOT6-11936ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CNOT6
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Involved Pathway

CNOT6 involved in several pathways and played different roles in them. We selected most pathways CNOT6 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNOT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA degradation
HSPD1; CNOT4B; PABPC1L; PFKL; CNOT8; EDC4; XRN2; DnaK; EXOSC2; PABPC1L2A

Protein Function

CNOT6 has several biochemical functions, for example, RNA binding, exonuclease activity, exoribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNOT6 itself. We selected most functions CNOT6 had, and list some proteins which have the same functions with CNOT6. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein KHDRBS3; ILF3A; TERT; RPL4; RDM1; NUFIP2; ASCC1; AGFG1A; RPL15; NOL9
Function exonuclease activity
Related Protein ISG20L2; EXO5; EXO1; RAD9; DOM3Z; EXOSC9; REXO1; CNOT6; FEN1; AEN
Function exoribonuclease activity
Related Protein CNOT6; CNOT7; EXOSC10
Function hydrolase activity
Related Protein INPP5L; GNPDA2; DDHD2; THTPA; FURINA; CHD9; CASPA; DUSP13A; PPM1DA; HINT1
Function metal ion binding
Related Protein ZNF576; CRBN; TRIM35-29; PRUNE; MSRB1A; GALNTL6; GTF3A; BRCC3; GUCA1B; SAP30
Function nuclease activity
Related Protein RNASEL2; RNASEL4; EXOSC9; GDPD4; ASTE1; DNASE1L3L; EAR5; ZRANB3; ANG3; EXOG
Function poly(A)-specific ribonuclease activity
Related Protein TOE1; PARN; CNOT7; CNOT6L; PDE12; PAN2; CNOT8; CNOT6

Interacting Protein

CNOT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNOT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNOT6.
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