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CRP

  • Official Full Name

    C-reactive protein, pentraxin-related

  • Overview

    The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
  • Synonyms

    CRP; C-reactive protein, pentraxin-related; PTX1; C-reactive protein; pentraxin 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Transfected Stable Cell Lines
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cat
  • Cattle
  • Chicken
  • Dog
  • Equine
  • Guinea pig
  • Horse
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Sheep
  • Zebrafish
  • Canine Serum
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Plasma
  • Human Pleural Fluid
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Normal Rhesus Monkey Serum
  • NS0
  • Plasma
  • Rabbit Serum
  • Rat Serum
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|S
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CRP-8544H Recombinant Human CRP, None tagged Human Cell N/A
Human CRP-26069TH Recombinant Human CRP E.coli N/A 226 amino acids
Human CRP-226H Active Recombinant Human CRP Protein NS0
Human CRP-111H Recombinant Human C-reactive Protein, Pentraxin-related E.coli N/A
Human CRP-26070TH Recombinant Human CRP, His-tagged E.coli His
Human CRP-7313H Recombinant Human CRP protein, His-tagged HEK293 His Phe17-Pro224
Human CRP-1904H Recombinant Human CRP Protein, GST-tagged Wheat Germ GST
Human CRP-1165HCL Recombinant Human CRP cell lysate Human Cell N/A
Human CRP-8057H Native C-Reactive Protein Human Pleural Fluid N/A
Human CRP-008H Recombinant Human CRP Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CRP-8H Active Human CRP Reference Standard N/A
Human CRP-2093HF Recombinant Full Length Human CRP Protein, GST-tagged In Vitro Cell Free System GST 91 amino acids
Human CRP-8374H Native Human CRP Plasma N/A
Human CRP-725HFL Recombinant Full Length Human CRP Protein, C-Flag-tagged Mammalian cells Flag
Human CRP-4303H Native Human C-reactive Protein Human Plasma N/A
Human CRP-1812H Recombinant Human CRP Protein (Gln19-Pro224), C-His tagged E.coli C-His Gln19-Pro224
Human CRP-904HG GMP Recombinant Human CRP protein HEK293 DNA sequence encoding Human CRP(NCBI Reference Sequence: NP_000558.2) was expressed with His tag at the C-terminal.
Human CRP-664H Recombinant Human CRP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CRP-4021H Recombinant Human CRP protein, His-tagged E.coli His 1-91 aa
Human CRP-1813H Recombinant Human CRP Protein (Gln19-Pro224), C-His tagged Mammalian cells C-His Gln19-Pro224
Human CRP-04H Recombinant Human CRP Protein, His-tagged HEK293 His
Human CRP-78H Human C-Reactive Protein Reference standard N/A
Human CRP-109H Recombinant Human CRP Protein, His-tagged HEK293 His 224
Human CRP-1814H Recombinant Human CRP Protein (Gln19-Pro224), N-His tagged E.coli N-His Gln19-Pro224
Human CRP-0002H Recombinant Human CRP Protein HEK293 cells
Human CRP-1816H Recombinant Human CRP Protein (Phe17-Pro224), N-His tagged E.coli N-His Phe17-Pro224
Human CRP-664H-B Recombinant Human CRP Protein Pre-coupled Magnetic Beads HEK293
Human CRP-8056H Native Human C-Reactive Protein Human Pleural Fluid N/A
Human CRP-5299H Native Human C-Reactive Protein, Pentraxin-Related Human Pleural Fluid N/A
Human CRP-3322H Recombinant Human CRP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CRP-508H Recombinant Human CRP protein, Biotinylated HEK293 N/A Met1-Pro224
Mouse Crp-7774M Recombinant Mouse Crp protein, His-tagged E.coli His His20~Ser225
Mouse Crp-3291M Recombinant Mouse Crp, His tagged Human Cell His
Mouse CRP-2292MCL Recombinant Mouse CRP cell lysate Human Cell N/A
Mouse Crp-849M Recombinant Mouse Crp Protein, His-tagged HEK293F N-His His20-Ser225
Mouse Crp-2319M Recombinant Mouse Crp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Crp-34M Mouse C-Reactive Protein Reference Standard N/A
Rat Crp-231R Active Recombinant Rat Crp protein, His-tagged Mammalian cells His
Rat Crp-7776R Recombinant Rat Crp protein, His & T7-tagged E.coli His/T7 His20~Ser230 (Accession # P48199)
Rat Crp-358R Recombinant Rat Crp Protein, His-tagged Insect Cell His
Rat Crp-4095R Recombinant Rat Crp, His tagged Human Cell His
Rat CRP-1945RCL Recombinant Rat CRP cell lysate Human Cell N/A
Rat Crp-75R Rat CRP Reference Standard N/A
Rat Crp-5382R Native Rat C-Reactive Protein, Petaxin Related Rat Serum N/A
Rat Crp-1264R Recombinant Rat Crp Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CRP-8059R Native Rat Serum C-Reactive Protein Rat Serum N/A
Rat Crp-1264R-B Recombinant Rat Crp Protein Pre-coupled Magnetic Beads HEK293
Rabbit CRP-7777R Recombinant Rabbit CRP protein, His-tagged E.coli His Ala21~Pro225
Rabbit CRP-158R Native Rabbit C-Reactive Protein Rabbit Serum N/A
Rabbit CRP-65R Rabbit C-Reactive Protein Reference Standard N/A
Dog CRP-2733D Recombinant Dog CRP Protein, His-tagged E.coli N-His Gln20-Ser223
Dog CRP-18D Dog C-Reactive Protein Reference Standard N/A
Canine CRP-5330H Native Canine CRP protein Canine Serum N/A
Canine CRP-59C Native Canine C-Reactive Protein Canine Serum N/A
Cat CRP-8C Cat C-Reactive Protein Reference Standard N/A
Cattle CRP-7771C Recombinant Cattle CRP protein, His & T7-tagged E.coli His/T7 Phe14~Trp224 (Accession # C4T8B4)
Cattle CRP-0043C Recombinant Canine CRP Protein HEK293 cells
Equine CRP-27H Horse C-Reactive Protein Reference Standard N/A
Guinea pig Crp-7773G Recombinant Guinea pig Crp protein, His & S-tagged E.coli His/S Gly20~Pro225 (Accession # P49254)
Horse CRP-847H Recombinant Horse CRP Protein, His-tagged E.coli N-His Gln20-Ser223
Rhesus Macaque CRP-159M Native Rhesus Monkey C-Reactive Protein Normal Rhesus Monkey Serum N/A
Sheep CRP-1741S Recombinant Sheep CRP Protein, His-tagged E.coli N-His Gln20-Trp224
Zebrafish CRP-4437Z Recombinant Zebrafish CRP Mammalian Cell His
Zebrafish crp-848Z Recombinant Zebrafish crp Protein, His-tagged E.coli N-His Phe19-Asn225
Pig CRP-7775P Recombinant Pig CRP protein, His-tagged E.coli His Gln20~Pro222
Pig CRP-59P Pig C-Reactive Protein Reference Standard N/A
Chicken CRP-7772C Recombinant Chicken CRP protein, His & T7-tagged E.coli His/T7 Gln20~Ala227 (Accession# Q2EJU6)
Chicken CRP-3391C Recombinant Chicken CRP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CRP Related Articles
  • CRP Related Research Area

CRP involved in several pathways and played different roles in them. We selected most pathways CRP participated on our site, such as Classical antibody-mediated complement activation, Complement cascade, Creation of C4 and C2 activators, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Classical antibody-mediated complement activationC1rb;IGLC2;IGKV1-5;IgG3;CRP;IGKC
Complement cascadeIGKC;IGLC2;HBL3;MASP2;BFB;CFHL4;IgG3;CFD;CR1
Creation of C4 and C2 activatorsIGKC;IGKV1-5;CRP;FCN3;C1rb;FCN2;IgG3;HBL3;MASP2
IL6-mediated signaling eventsLMO4;JUNB;PIAS3;CRP
Immune SystemDTX3L;PAG1;TRIM56;CFHL3;CLEC2G;RNF138;TAX1BP1B;KIF20A;ABI1
Initial triggering of complementFCN1;FCN2;MASP2;HBL3;CFD;FCN3;CRP;GZMM;C1rb
Innate Immune SystemTXNIPA;IFI16;UNC93B1;PELI3;FCN1;BTR09;DHX9;CRCP;POLR3C
Selenium PathwayMSRB1;ALOX5AP;PRDX2;SERPINA3;SAA2;PRDX4;SAA2-SAA4;TXNRD2;DIO2

CRP has several biochemical functions, for example, calcium ion binding, choline binding, complement component C1q binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRP itself. We selected most functions CRP had, and list some proteins which have the same functions with CRP. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingBRAF;ANXA5;EFEMP1;LALBA;EHD1;MMP28;MMP8;CABP1B;PLCZ1
choline bindingSLC5A7;CHKA;CRP;BCHE
complement component C1q bindingPTX3;C1QBP;APCS;C4A;CRP;CD93;CALR
low-density lipoprotein particle bindingCRP;ANKRA2;PCSK9;MSR1;LIPC;CDH13;LDLR;COLEC12;THBS1
low-density lipoprotein particle receptor bindingAPOB;MESDC2;CRP;AP2M1;SYT1;DNAJA1;SACS;LRPAP1;SNX17
protein bindingLCE3E;ZNF136;MBD4;PVRL2;RAET1D;PTPRS;STX6;GNAI2;CLTB
NOT virion binding

CRP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRP here. Most of them are supplied by our site. Hope this information will be useful for your research of CRP.

GMPPA; spa; FCN2; FCGR2A; FCGR2C; GLUD1; MAPK3; MAPK1; RPL13A; MAPK8IP2; DGCR14; LAMC3

Vashist, SK; Schneider, EM; et al. Graphene-based rapid and highly-sensitive immunoassay for C-reactive protein using a smartphone-based colorimetric reader. BIOSENSORS & BIOELECTRONICS 66:169-176(2015).
Ahmed, N; Petersson, A; et al. Tumor necrosis factor mediates temporomandibular joint bone tissue resorption in rheumatoid arthritis. ACTA ODONTOLOGICA SCANDINAVICA 73:232-240(2015).
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