Recombinant Human CRP Protein, His-tagged

• Cat.No.: CRP-04H
• Product Overview: Recombinant human C-Reactive/CRP (19-224aa), fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Specification

• Description: The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 infection.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Liquid
• Molecular Mass: 24.1 kDa (215aa)
• AA Sequence: QTDMSRKAFVFPKESDTSYVSLKAP LTKPLKAFTVCLHFYTELSSTRGYS IFSYATKRQDNEILIFWSKDIGYSF TVGGSEILFEVPEVTVAPVHICTSW ESASGIVEFWVDGKPRVRKSLKKGY TVGAEASIILGQEQDSFGGNFEGSQ SLVGDIGNVNMWDFVLSPDEINTIY LGGPFSPNVLNWRALKYEVQGEVFT KPQLWP
• Purity: > 90% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/mL (determined by Absorbance at 280nm)
• Storage Buffer: In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Gene Information

• Gene Name: CRP C-reactive protein [ Homo sapiens (human) ]
• Official Symbol: CRP
• Synonyms: CRP; C-reactive protein; PTX1; C-reactive protein; C-reactive protein, pentraxin-related; pentraxin 1
• Gene ID: 1401
• mRNA Refseq: NM_000567
• Protein Refseq: NP_000558
• MIM: 123260
• UniProt ID: P02741