Recombinant Full Length Human CRP Protein, C-Flag-tagged

• Cat.No.: CRP-725HFL
• Product Overview: Recombinant Full Length Human CRP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 infection.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 23 kDa
• AA Sequence: MEKLLCFLVLTSLSHAFGQTDMSRK AFVFPKESDTSYVSLKAPLTKPLKA FTVCLHFYTELSSTRGYSIF SYATKRQDNEILIFWSKDIGYSFTV GGSEILFEVPEVTVAPVHICTSWES ASGIVEFWVDGKPRVRKSLK KGYTVGAEASIILGQEQDSFGGNFE GSQSLVGDIGNVNMWDFVLSPDEIN TIYLGGPFSPNVLNWRALKY
  EVQGEVFTKPQLWPTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Secreted Protein

Gene Information

• Gene Name: CRP C-reactive protein [ Homo sapiens (human) ]
• Official Symbol: CRP
• Synonyms: PTX1
• Gene ID: 1401
• mRNA Refseq: NM_000567.3
• Protein Refseq: NP_000558.2
• MIM: 123260
• UniProt ID: P02741