CTHRC1
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Official Full Name
collagen triple helix repeat containing 1
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Overview
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] -
Synonyms
CTHRC1; collagen triple helix repeat containing 1; collagen triple helix repeat-containing protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- Flag|Reg
- GST
- hFc
- His (Fc)
- Avi
- Myc
- MBP
- MBP|His
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CTHRC1 Related Articles
- CTHRC1 Related Research Area
CTHRC1 involved in several pathways and played different roles in them. We selected most pathways CTHRC1 participated on our site, such as Noncanonical Wnt signaling pathway, Wnt signaling network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTHRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Noncanonical Wnt signaling pathway | CHD7;CTHRC1;ROR2 |
Wnt signaling network | CTHRC1;IGFBP4;WIF1;ATP6AP2;RSPO1;RYK |
CTHRC1 has several biochemical functions, for example, Wnt-protein binding, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTHRC1 itself. We selected most functions CTHRC1 had, and list some proteins which have the same functions with CTHRC1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
Wnt-protein binding | FZD10;FZD8B;SFRP2;SETD6;FRZB;Fzd4;FZD9;FZD7;FZD6 |
frizzled binding | DVL3A;NDP;FZD1;RSPO3;ROR2;WNT2;WNT4B;WNT16;ZNRF3 |
CTHRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTHRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTHRC1.
ZDHHC17; TFAP2C
- Q&As
- Reviews
Q&As (7)
Ask a questionEnvironmental factors, inflammatory responses, and mechanical stress can regulate the expression and activity of CTHRC1.
CTHRC1 promotes cell migration and downregulates collagen synthesis in tissue repair, aiding in tissue remodeling.
Structural changes in CTHRC1 may affect its interactions with the extracellular matrix and other proteins, altering its function.
The interaction of CTHRC1 with the Wnt signaling pathway influences cell proliferation and differentiation, especially in cancer and tissue repair.
In cardiovascular diseases, CTHRC1 is involved in the remodeling and repair of blood vessels.
CTHRC1 enhances cancer cell invasiveness and metastatic potential by facilitating extracellular matrix remodeling and signal transduction.
CTHRC1 expression is often increased in various cancers, associated with aggressiveness and severity of the disease.
Customer Reviews (3)
Write a reviewConsistent quality, a go-to for researchers.
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