CYP7A1 Protein, cytochrome P450, family 7, subfamily A, polypeptide 1

CYP7A1

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CYP7A1

Official Full Name cytochrome P450, family 7, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
Synonyms CYP7A1; cytochrome P450, family 7, subfamily A, polypeptide 1; CP7A; CYP7; CYPVII; cholesterol 7-alpha-monooxygenase; cytochrome P450 7A1; cholesterol 7-alpha-hydroxylase; cytochrome P450, subfamily VIIA polypeptide 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP7A1-2291H Recombinant Human CYP7A1 Protein, GST-tagged Wheat Germ GST
    Human CYP7A1-7099HCL Recombinant Human CYP7A1 293 Cell Lysate HEK293 N/A
    Mouse Cyp7a1-1440M Recombinant Mouse Cyp7a1 protein, His & T7-tagged E.coli His/T7
    Mouse CYP7A1-4232M Recombinant Mouse CYP7A1 Protein Mammalian Cell His
    Rat Cyp7a1-1441R Recombinant Rat Cyp7a1 protein, His & T7-tagged E.coli His/T7
    Rat CYP7A1-1757R Recombinant Rat CYP7A1 Protein Mammalian Cell His
    Rhesus Macaque CYP7A1-1166R Recombinant Rhesus monkey CYP7A1 Protein, His-tagged Mammalian Cell His
    Chicken CYP7A1-1149C Recombinant Chicken CYP7A1 Mammalian Cell His

    CYP7A1 involved in several pathways and played different roles in them. We selected most pathways CYP7A1 participated on our site, such as Bile acid and bile salt metabolism, Bile secretion, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP7A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bile acid and bile salt metabolism AKR1C21; AKR1C6; AKR1C2; SLC27A2; SLC27A2A; CYP8B2; SCP2B; SLCO1B1; SLC27A5; CYP46A1
    Bile secretion ABCG2; SLC10A2; SLC5A1; ADCY7; ABCC3; PRKACB; SLC2A1; EPHX1; CYP3A4; SLC51A
    Biological oxidations CYP2K19; CYP3C4; CYP2A6; ADH6; SLC35B2; CYP2V1; ACY3.2; CYP19A1; CYP2F1; CYP2K16
    Cytochrome P450 - arranged by substrate type CYP2AD2; CYP3A7-CYP3AP1; CYP8B2; CYP11A1; CYP7A1; CYP11B1; FAM84B; CYP2AD6; CYP2F1; CYP2V1
    Drug Induction of Bile Acid Pathway NR1I3; SLC51B; ABCC2; NR1I2; CYP7A1; SLCO1B1
    Endogenous sterols POMCB; CYP11B1; FDXR; CYP7A1; CYP19A1; FDX1L; CYP11B2; FDX1; CYP21A2; CYP46A1
    Fatty acid, triacylglycerol, and ketone body metabolism MED8; ACOT7; MED25; GRHL1; TIAM2; MED7; AGPAT1; CYP4A11; SIN3B; SREBF2
    Metabolic pathways CBS; ITPKC; CDO1; AOX3L1; TYRP1B; MAT2AL; CSGALNACT1; OLAH; CERS2; MGAT1A

    CYP7A1 has several biochemical functions, for example, cholesterol 7-alpha-monooxygenase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP7A1 itself. We selected most functions CYP7A1 had, and list some proteins which have the same functions with CYP7A1. You can find most of the proteins on our site.

    Function Related Protein
    cholesterol 7-alpha-monooxygenase activity CYP7A1A; CYP7A1
    heme binding PTGS2A; SDHC; SUOX; CYP3A43; CYP2N13; CYP3C4; CYP2K16; HRG-1; CYP1A1; CYP39A1
    iron ion binding HIF1AN; CYP2K6; HBBE2; NDOR1; CYP1A; CYP51A1; CYP1D1; CYP4T8; CYP2AA2; CYP2W1

    CYP7A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP7A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP7A1.

    Reiner, Z; et al. Resistance and intolerance to statins. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 24:1057-1066(2014).
    Kong, B; Guo, GL; et al. Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli. PLOS ONE 9:-(2014).

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