ccl12
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  • Official Full Name
  • chemokine (C-C motif) ligand 12
  • Background
  • Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
  • Synonyms
  • CCL12; chemokine (C-C motif) ligand 12; C-C motif chemokine 12; Macrophage/monocyte Chemotactic Protein; OTTMUSP00000000792; Scya12; Small inducible cytokine A12; MCP-1-related chemokine; small-inducible cytokine A12; monocyte chemotactic protein 5; monocyte chemoattractant protein 5; MCP-5
Cat.#:Ccl12-310MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Ccl12 Protein, His-tagged
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Cat.#:Ccl12-93MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-C Motif) Ligand 12
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Cat.#:Ccl12-621MTag:N/A
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Ccl12 protein
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Involved Pathway

Ccl12 involved in several pathways and played different roles in them. We selected most pathways Ccl12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
OSMR; TGFBR1; TGFBR1A; TNFSF18; TNFRSF19; BMP7; CCL16; BMPR2; ACVR1L; TNFSF15
Chemokine signaling pathway
CCR9; GSK3B; CCL2; GM2506; ROCK1; RLN1; CCL16; CXCL1; SHC1; CXCL13
NOD-like receptor signaling pathway
MAPK14A; MAPK8; CXCL2; NAIP6; NFKBIAA; MAP3K7IP3; BIRC3; NLRP3; NFKB1; TRAF6
TNF signaling pathway
MLKL; TNFRSF1B; IL15; MAGI2; CXCL3; FAS; PIK3R1; PTGS2; AKT2; MAPK10
Chagas disease (American trypanosomiasis)
RELA; CASP8; CD247; Fasl; PIK3CA; IKBKG; NOS2; MAPK12; CALR; SMAD2
Malaria
KLRB1; TLR2; TLR9; GYPA; IL18; IL12A; KLRC4-KLRK1; COMP; ICAM1; TGFB3
Influenza A
NXT2; NFKBIB; EIF2AK1; DDX58; HSPA2; IL12A; KPNA2; BCL2L2-PABPN1; HLA-DPA1; PIK3R5
Herpes simplex infection
HLA-C; IFNA1; HLA-DQA2; IKBKB; CDC34A; EIF2AK4; IKBKG; SRPK1B; TAF3; HLA-DPA1
Rheumatoid arthritis
CXCL6; Ctsl; TNFSF11; CCL5; IL15; ATP6V0E2; ATP6V1B2; ACP5; ATP6V0A1; HLA-DMA

Protein Function

Ccl12 has several biochemical functions, for example, CCR2 chemokine receptor binding, chemokine activity, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl12 itself. We selected most functions Ccl12 had, and list some proteins which have the same functions with Ccl12. You can find most of the proteins on our site.
Function
Related Protein
Function CCR2 chemokine receptor binding
Related Protein CCL7; Ccl12; CCL2
Function chemokine activity
Related Protein CCL34B.4; CXCL11.8; CCL34A.4; CCL34B.9; XCL2; CCL22; CX3CL1; Ccl21a; CCL1; CCL38A.5
Function cytokine activity
Related Protein IFNB1; GDF2; TGFB1A; IL17F; TNFSF14; IL1F10; BMP7; CSF2; LIF; IL1RN

Ccl12 Related Articles

Marazioti, A; Stathopoulos, GT; et al. Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion. ONCOIMMUNOLOGY 3:-(2014).
Marazioti, A; Kairi, CA; et al. Beneficial Impact of CCL2 and CCL12 Neutralization on Experimental Malignant Pleural Effusion. PLOS ONE 8:-(2013).

Ccl12 Related Gene Family

Chemokines Cytokines