DNM2
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Official Full Name
dynamin 2
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Overview
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010] -
Synonyms
DNM2; dynamin 2; DYN2; CMT2M; DYNII; LCCS5; CMTDI1; CMTDIB; DI-CMTB; dynamin-2; dynamin II;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
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- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- DNM2 Related Articles
- DNM2 Related Signal Pathway
DNM2 involved in several pathways and played different roles in them. We selected most pathways DNM2 participated on our site, such as Adaptive Immune System, Arf6 trafficking events, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | CD200R2;TPP2;KIR2DS2;HCST;SRMS;CD300C;CDKN1A;CLEC2G;CTSK |
| Arf6 trafficking events | SPAG9;EXOC1;EXOC6;EDNRB;EXOC3;SCAMP2;EXOC5;CLTC;CTNND1 |
| Axon guidance | COL9A1;DPYSL5B;CDC42;FGF8B;HFE2;FGF18B;SEMA3B;LOC608458;CXCL12 |
| Bacterial invasion of epithelial cells | SEPT1;ELMO2;WASF2;RAC1;PXN;PIK3CA;CLTC;CTNNA2;ITGB1 |
| Clathrin derived vesicle budding | BLOC1S3;PICALMA;YIPF6;AP4B1;NECAP1;SNX9B;DNM2;APPA;AP1S3A |
| Developmental Biology | PRDM14;ARPC4;COL6A1;GDF1;LAMTOR2;DUSP2;CLTA;KALRNB;EVL |
| Endocrine and other factor-regulated calcium reabsorption | ATP1B1;TRPV5;ATP2B1;ATP1A1;KLK1B26;ATP1A3;PLCB1;KLK1B22;KLK1B3 |
| Endocytosis | GRK1B;NTRK1;FGFR3;EPN3;ARPC2;BC2;HLA-F;HLA-G;TGFBR1 |
DNM2 has several biochemical functions, for example, D2 dopamine receptor binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM2 itself. We selected most functions DNM2 had, and list some proteins which have the same functions with DNM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| D2 dopamine receptor binding | PPP1R9B;CLIC6;DNM2 |
| GTP binding | ARL4AA;GNA13;RAB42;SEPT5;MFHAS1;RP2;IFT22;MRAS;RSG1 |
| GTPase activity | RALAB;GNAS;EEF1A1L2;SEPT9;RAB18B;ADSSL1;RHOJ;RRAGCB;GNAIA |
| SH3 domain binding | PDCD6IP;RAD9A;SH3BGR;CBLC;FUT8;ARHGAP17;SH3BGRL;EPS15;ARHGAP6 |
| WW domain binding | SCNN1G;TRP63;NFE2;ATCAY;CDC25C;DAZAP2;PMEPA1;TMEM128;SHISA5 |
| enzyme binding | TH;MAPK14;RPS19BP1;HIST1H2AG;SCN5A;PAWR;PDCD2;DYM;CYP1A1 |
| microtubule binding | SNCA;LC3;KIF2A;CASC1;MAPRE1B;WHAMM;KATNAL1;NUSAP1;ZNF207 |
| nitric-oxide synthase binding | DNM2;SLC14A2;SLC6A4;CALM2;DMD;CDH2;CAMK2D;SNTA1;CAV3 |
| phosphatidylinositol 3-kinase regulatory subunit binding | PIK3R1;FAM83B;FAM83A;DNM2;PTPN13;XBP1;PIK3AP1 |
| protein binding | CLSTN1;ATP1A1;TIA1;SETMAR;PRPS2;TRAF2;HMOX1;RPL30;SLC22A3 |
| protein kinase binding | DNM1;FOXO3;SMAD3;CCNA2;TRIB3;JIP1;DLG1;PRKAG3;CALM2 |
DNM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM2.
GRB2; SNX9; SH3GL2; AMPH; ITSN1
- Q&As
- Reviews
Q&As (6)
Ask a questionDNM2 interacts with β-actin.
DNM2 is closely associated with the study of chronic heart failure and chronic progressive extraocular muscle paralysis in the elderly.
DNM2 gene is widely expressed in various mammalian tissues.
DNM1 and DNM3 are all homologs of DNM2.
DNM2 is involved in the regulation of Golgi reticular system transport, mitochondrial fusion, cytoplasmic division and synaptic vesicle endocytosis.
N-terminal GTPase structural domain, intermediate domain, PH structural domain, GTPase effector structural domain, and C-terminal proline- and arginine-rich domain.
Customer Reviews (3)
Write a reviewDNM2 proteins purchased are as advertised and the quality of the product is guaranteed.
Excellent after-sales service, solving many experimental problems.
The technician gave me a thorough introduction to the DNM2 protein so that I could understand its biochemical properties.
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