Recombinant Human DNM2 Protein

• Cat.No.: DNM2-20H
• Product Overview: Recombinant Human DNM2 Protein expressed in E.coli.

Specification

• Description: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
• Source: E.coli
• Species: Human
• Form: Liquid. In 1xPBS, pH7.4.
• Molecular Mass: 41.0kDa
• Protein length: a.a.533-866
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMASMT GGQQMGRGSEFLMKGGSKEYWFVLT AESLSWYKDEEEKEKKYMLPLDNLK IRDVEKGFMSNKHVFAIFNTEQRNV YKDLRQIELACDSQEDVDSWKASFL RAGVYPEKDQAENEDGAQENTFSMD PQLERQVETIRNLVDSYVAIINKSI RDLMPKTIMHLMINNTKAFIHHELL AYLYSSADQSSLMEESADQAQRRDD MLRMYHALKEALNIIGDISTSTVST PVPPPVDDTWLQSASSHSPTPQRRP VSSIHPPGRPPAVRGPTPGPPLIPV PVGAAASFSAPPIPSRPGPQSVFAN SDLFPAPPQIPSRPVRIPPGIPPGV PSRRPPAAPSRPTIIRPAEP
• Purity: >90% as determined by SDS-PAGE
• Storage: Please prepare aliquots and store at -20~-80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.1 mg/ml
• Publication:
  Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis (2019)

Gene Information

• Gene Name: DNM2 dynamin 2 [ Homo sapiens (human) ]
• Official Symbol: DNM2
• Synonyms: DYN2; CMT2M; DYNII; LCCS5; CMTDI1; CMTDIB; DI-CMTB
• Gene ID: 1785
• mRNA Refseq: NM_004945.4
• Protein Refseq: NP_004936.2
• MIM: 602378
• UniProt ID: P50570

Reviews

03/02/2023

DNM2 proteins purchased are as advertised and the quality of the product is guaranteed.

08/16/2022

Excellent after-sales service, solving many experimental problems.

03/12/2022

The technician gave me a thorough introduction to the DNM2 protein so that I could understand its biochemical properties.

Q&As

What is the relationship between DNM2 and β-actin?

DNM2 interacts with β-actin.

What diseases is DNM2 primarily involved in?

DNM2 is closely associated with the study of chronic heart failure and chronic progressive extraocular muscle paralysis in the elderly.

Where is DNM2 primarily expressed?

DNM2 gene is widely expressed in various mammalian tissues.

What are the other homologous genes of DNM2?

DNM1 and DNM3 are all homologs of DNM2.

What biological processes is DNM2 involved in?

DNM2 is involved in the regulation of Golgi reticular system transport, mitochondrial fusion, cytoplasmic division and synaptic vesicle endocytosis.

What is the structure domain of DNM2?

N-terminal GTPase structural domain, intermediate domain, PH structural domain, GTPase effector structural domain, and C-terminal proline- and arginine-rich domain.