DRAP1

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DRAP1

Official Full Name DR1-associated protein 1 (negative cofactor 2 alpha)
Background Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
Synonyms DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; DR1 associated corepressor; NC2 alpha; negative cofactor 2 alpha; DR1 associated protein 1 (negative cofactor 2 alpha); DR1 associated protein 1; DR1 associated protein1; DRAP 1; NC 2 alpha; NC 2alpha; Negative cofactor 2alpha; OTTHUMP00000234061; OTTHUMP00000234062; OTTHUMP00000234063; OTTHUMP00000234065; OTTHUMP00000234066; negative co-factor 2-alpha; NC2-alpha
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DRAP1-1212H Recombinant Human DRAP1 Protein (4-198 aa), GST-tagged E.coli GST
    Human DRAP1-2670H Recombinant Human DRAP1, His-tagged E.coli His
    Human DRAP1-2873H Recombinant Human DRAP1 Protein, GST-tagged Wheat Germ GST
    Human DRAP1-6819HCL Recombinant Human DRAP1 293 Cell Lysate HEK293 N/A
    Rat DRAP1-1954R Recombinant Rat DRAP1 Protein Mammalian Cell His
    Rhesus Macaque DRAP1-1328R Recombinant Rhesus monkey DRAP1 Protein, His-tagged Mammalian Cell His
    Zebrafish DRAP1-11589Z Recombinant Zebrafish DRAP1 Mammalian Cell His

    DRAP1 involved in several pathways and played different roles in them. We selected most pathways DRAP1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology SPAG9; GFRA4; SPNA1; HIF3A; NKX2.2A; MED10; COL9A1B; COL9A1A; CNTN6; KBTBD7
    Signal Transduction ARHGAP6; MLN; UCHL5; PLEKHG2; GPR55A; GDI1; SCUBE2; CXCL11.8; SDR16C5; NPB
    Signaling by Activin FSTB; ACVR1C; FST; FSTL3; INHBAA; FOXH1; DRAP1
    Signaling by NODAL FOXH1; LEFTY1; DRAP1; PCSK6; CFC1; ACVR1C; TDGF1; GDF1

    DRAP1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by DRAP1 itself. We selected most functions DRAP1 had, and list some proteins which have the same functions with DRAP1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HIST1H2B5; E2F6; ZFP13; ZNF707; JUN; SNAPC4; OTX1A; IRX2A; NABP2; ZFP865
    protein binding SCNN1G; SF3A2; YARS2; TUBB4A; URM1; PROL1; NACC2; ATG5; GABRG2; GSDMD
    protein heterodimerization activity KCNH5; ADRA1B; SCUBE1; CUL3; H3F3B; TFDP3; GABRR1; BCL2L2; PAFAH1B2; ANO9A
    transcription corepressor activity CBFA2T3; HSF4; PIAS1; SAP30; RCOR2; NCOR2; SSX3; MSC; HDAC4; SIRT1
    transcription factor activity, sequence-specific DNA binding TBR1B; TAL1; DEAF1; NFIL3-2; HIF1A; ZFP354C; SMAD6A; EGR1; CREB3; GATA1A
    transcription factor binding CAMTA2; ID1; PSMD10; TAF12; MAPK1; LCOR; H2-AB1; SMARCA4; PER1; SOX10

    DRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRAP1.

    TAF9; NFYB; TAF9B; POLE3; LMO2

    Kantidakis, T; White, RJ; et al. Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells. NUCLEIC ACIDS RESEARCH 38:1228-1239(2010).
    Valdagni, R; Rancati, T; et al. TO BLEED OR NOT TO BLEED. A PREDICTION BASED ON INDIVIDUAL GENE PROFILING COMBINED WITH DOSE-VOLUME HISTOGRAM SHAPES IN PROSTATE CANCER PATIENTS UNDERGOING THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 74:1431-1440(2009).

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