drap1
Share
  • Official Full Name
  • DR1-associated protein 1 (negative cofactor 2 alpha)
  • Background
  • Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
  • Synonyms
  • DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; DR1 associated corepressor; NC2 alpha; negative cofactor 2 alpha; DR1 associated protein 1 (negative cofactor 2 alpha); DR1 associated protein 1; DR1 associated protein1; DRAP 1; NC 2 alpha; NC 2alpha; Negative cofactor 2alpha; OTTHUMP00000234061; OTTHUMP00000234062; OTTHUMP00000234063; OTTHUMP00000234065; OTTHUMP00000234066; negative co-factor 2-alpha; NC2-alpha
Cat.#:DRAP1-2873HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DRAP1 Protein, GST-tagged
+Inquiry
Cat.#:DRAP1-2670HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DRAP1, His-tagged
+Inquiry
Cat.#:DRAP1-1954RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DRAP1 Protein
+Inquiry
Cat.#:DRAP1-1328RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DRAP1 Protein, His-tagged
+Inquiry
Cat.#:DRAP1-11589ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DRAP1
+Inquiry
Cat.#:DRAP1-6819HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DRAP1 293 Cell Lysate
+Inquiry

Involved Pathway

DRAP1 involved in several pathways and played different roles in them. We selected most pathways DRAP1 participated on our site, such as Developmental Biology, Signal Transduction, Signaling by Activin, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRAP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
SHB; TRPC4; CDK5R1B; EFNA1; CLTA; MED21; MED15; LGI2B; EFNA3; DUSP1
Signal Transduction
NCKIPSD; USP9X; WIPF2; MDKA; NRP2B; EVC; BOC; AES; SKI; CD97
Signaling by Activin
ACVR1C; INHBAA; FST; DRAP1; FSTB; FOXH1; FSTL3
Signaling by NODAL
FOXH1; TDGF1; DRAP1; ACVR1C; GDF1; LEFTY1; PCSK6; CFC1

Protein Function

DRAP1 has several biochemical functions, for example, DNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DRAP1 itself. We selected most functions DRAP1 had, and list some proteins which have the same functions with DRAP1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein CDK9; HLTF; NR5A1B; HIST1H4K; TFAP2C; SMAD6A; HOXB1A; STAT2; POLR3B; HIST1H2AE
Function protein binding
Related Protein UBE2D4; EFNB2; FAIM; IFT88; KDM5B; LINGO1B; GMCL1P1; VEGFC; SLC14A2; APEX1
Function protein heterodimerization activity
Related Protein TAS1R3; VOX; JAM3; KCNIP1; ATP4A; TIMELESS; Pdgfa&Pdgfb; DMRT3; H2AFY2; HIST1H4J
Function transcription corepressor activity
Related Protein HSF4; CDX2; SAP30; SFMBT1; ZFPM2; ELK3; BHLHE40; TGIF1; RELB; JUNB
Function transcription factor activity, sequence-specific DNA binding
Related Protein ESR2; KLF12; HSF1; FLI1; HOXB7A; SOX3; CBL; SOX13; JUNBB; NR1H4
Function transcription factor binding
Related Protein RELA; PPP1R13BA; MECP2; BCL10; PURB; PIK3R1; HMGA1; PPID; MDFI; SP1

Interacting Protein

DRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRAP1.
TAF9; NFYB; TAF9B; POLE3; LMO2

DRAP1 Related Articles

Kantidakis, T; White, RJ; et al. Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells. NUCLEIC ACIDS RESEARCH 38:1228-1239(2010).
Valdagni, R; Rancati, T; et al. TO BLEED OR NOT TO BLEED. A PREDICTION BASED ON INDIVIDUAL GENE PROFILING COMBINED WITH DOSE-VOLUME HISTOGRAM SHAPES IN PROSTATE CANCER PATIENTS UNDERGOING THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 74:1431-1440(2009).