|Official Full Name||DR1-associated protein 1 (negative cofactor 2 alpha)|
|Background||Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.|
|Synonyms||DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; DR1 associated corepressor; NC2 alpha; negative cofactor 2 alpha; DR1 associated protein 1 (negative cofactor 2 alpha); DR1 associated protein 1; DR1 associated protein1; DRAP 1; NC 2 alpha; NC 2alpha; Negative cofactor 2alpha; OTTHUMP00000234061; OTTHUMP00000234062; OTTHUMP00000234063; OTTHUMP00000234065; OTTHUMP00000234066; negative co-factor 2-alpha; NC2-alpha|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
DRAP1 involved in several pathways and played different roles in them. We selected most pathways DRAP1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Developmental Biology||SPAG9; GFRA4; SPNA1; HIF3A; NKX2.2A; MED10; COL9A1B; COL9A1A; CNTN6; KBTBD7|
|Signal Transduction||ARHGAP6; MLN; UCHL5; PLEKHG2; GPR55A; GDI1; SCUBE2; CXCL11.8; SDR16C5; NPB|
|Signaling by Activin||FSTB; ACVR1C; FST; FSTL3; INHBAA; FOXH1; DRAP1|
|Signaling by NODAL||FOXH1; LEFTY1; DRAP1; PCSK6; CFC1; ACVR1C; TDGF1; GDF1|
DRAP1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by DRAP1 itself. We selected most functions DRAP1 had, and list some proteins which have the same functions with DRAP1. You can find most of the proteins on our site.
|DNA binding||HIST1H2B5; E2F6; ZFP13; ZNF707; JUN; SNAPC4; OTX1A; IRX2A; NABP2; ZFP865|
|protein binding||SCNN1G; SF3A2; YARS2; TUBB4A; URM1; PROL1; NACC2; ATG5; GABRG2; GSDMD|
|protein heterodimerization activity||KCNH5; ADRA1B; SCUBE1; CUL3; H3F3B; TFDP3; GABRR1; BCL2L2; PAFAH1B2; ANO9A|
|transcription corepressor activity||CBFA2T3; HSF4; PIAS1; SAP30; RCOR2; NCOR2; SSX3; MSC; HDAC4; SIRT1|
|transcription factor activity, sequence-specific DNA binding||TBR1B; TAL1; DEAF1; NFIL3-2; HIF1A; ZFP354C; SMAD6A; EGR1; CREB3; GATA1A|
|transcription factor binding||CAMTA2; ID1; PSMD10; TAF12; MAPK1; LCOR; H2-AB1; SMARCA4; PER1; SOX10|
DRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRAP1.
TAF9; NFYB; TAF9B; POLE3; LMO2