Recombinant Human DRAP1, His-tagged

• Cat.No.: DRAP1-2670H
• Product Overview: Recombinant Human DRAP1with a His tag is expressed inE. coli.MW: 28±5 KDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex.
• Formulation: 20% Glycerol solution at 0.20 mg/ml.
• Activity: Interacts with TBP and prevents the TBP-IIB-IIA complex required for transcription.
• Storage: Store at -80°C. At least 1 year at -80°C.

Gene Information

• Gene Name: DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) [ Homo sapiens ]
• Synonyms:
  DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; negative co-factor 2-alpha; negative cofactor 2 alpha; NC2-alpha
• Gene ID: 10589
• mRNA Refseq: NM_006442
• Protein Refseq: NP_006433
• MIM: 602289
• UniProt ID: Q14919
• Chromosome Location: 11q13.3
• Pathway: Cell Cycle, Mitotic; Nucleotide excision repair; DNA Repair; Gene Expression; HIV Infection; Transcription; mRNA Processing
• Function: DNA binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity