e2f1
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  • Official Full Name
  • E2F transcription factor 1
  • Background
  • The E2F transcription factors are essential for regulation of the cell cycle. Physiological E2F is a heterodimer composed of an E2F subunit together with a DP subunit. Six members of the E2F family have been identified, and each E2F subunit has a DNA bind
  • Synonyms
  • E2F1; E2F transcription factor 1; RBBP3; transcription factor E2F1; RBP3; PBR3; RBAP-1; RBBP-3; PRB-binding protein E2F-1; retinoblastoma-binding protein 3; retinoblastoma-associated protein 1; E2F-1; RBAP1
Cat.#:E2F1-3002HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human E2F1 Protein, GST-tagged
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Cat.#:E2F1-1031HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human E2F1, His-tagged
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Cat.#:E2F1-12245HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E2F1, GST-tagged
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Cat.#:E2F1-238HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human E2F1, MYC/DDK-tagged
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Cat.#:E2F1-26458THTag:
Source (Host):Species:Human
Product nameRecombinant Human E2F1
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Cat.#:E2F1-8451HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human E2F1, His-tagged
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Cat.#:E2F1-6772CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken E2F1
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Cat.#:E2F1-6743HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human E2F1 293 Cell Lysate
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Involved Pathway

E2F1 involved in several pathways and played different roles in them. We selected most pathways E2F1 participated on our site, such as Activation of BH3-only proteins, Activation of NOXA and translocation to mitochondria, Activation of PUMA and translocation to mitochondria, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of BH3-only proteins
AKT3; DYNLL2; CDK5RAP2; E2F1; BCL2L11; YWHAQ
Activation of NOXA and translocation to mitochondria
E2F1
Activation of PUMA and translocation to mitochondria
E2F1
Adipogenesis
SMAD3B; NCOA2; CNTFR; MBNL1; CEBPB; E2F4; EBF1; NDN; RORAA; BSCL2
Apoptosis
PPP3CB; CDKN2A; NTRK1; NGF; CASP6; CSF2RB; PPP3CA; RELA; IKBKB; PIK3CD
Assembly of the pre-replicative complex
E2F3; E2F2; E2F1; MCM8; CDT1; GMNN
Association of licensing factors with the pre-replicative complex
CDT1; E2F3; E2F2; E2F1; GMNN
Bladder cancer
HRAS; RPS6KA5; MDM2; CDH1; RB1; MMP1A; NRAS; DAPK2; CXCL8; CDK4

Protein Function

E2F1 has several biochemical functions, for example, DNA binding, core promoter binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F1 itself. We selected most functions E2F1 had, and list some proteins which have the same functions with E2F1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein CEBPA; CTC1; GATA3; SOX1; HOXA4A; HIST1H2AA; ZNF683; ZBTB7B; FOXG1C; HOXC3A
Function core promoter binding
Related Protein MTA1; ARNTL; NPAS2; E2F8; HDAC4; NEUROG3; FOXO3; HDAC6; INSM1A; NKX3
Function protein binding
Related Protein MAPK10; ARMC1; PLEKHG4; RNF138; ARMC8; TARS; GLRB; Itga10&Itgb1; NUF2; MOBP
Function protein kinase binding
Related Protein CCNA2; ITGB1BP1; CDC25C; YWHAZ; CDKN2B; MAVS; DLG1; TRIM6; DUSP3; AP1B1
Function sequence-specific DNA binding
Related Protein ELF2A; LBX1; LHX9; GRHL3; HOXA3A; BCL11AB; NKX6-1; FOXB1B; DBX1B; FOXQ2
Function transcription factor activity, sequence-specific DNA binding
Related Protein STAT1B; FOXD4; GCM1; ATF7B; PLAG1; SOX11B; ELF2; BATF; HIF1A; ZNF192
Function transcription factor binding
Related Protein BCL2; HMGA1-RS1; PDX1; TCF3; PBX1; KCTD1; JUNBA; AHR; NR0B2A; DACT2

Interacting Protein

E2F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F1.
RB1

E2F1 Related Articles

Wu, M; Zhou, JL; et al. E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression. CARDIOVASCULAR RESEARCH 104:412-422(2014).
Jiang, DF; Aguiar, RCT; et al. MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-beta 1/SMAD5 signaling module. BLOOD 123:86-93(2014).