e2f1
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  • Official Full Name
  • E2F transcription factor 1
  • Background
  • The E2F transcription factors are essential for regulation of the cell cycle. Physiological E2F is a heterodimer composed of an E2F subunit together with a DP subunit. Six members of the E2F family have been identified, and each E2F subunit has a DNA bind
  • Synonyms
  • E2F1; E2F transcription factor 1; RBBP3; transcription factor E2F1; RBP3; PBR3; RBAP-1; RBBP-3; PRB-binding protein E2F-1; retinoblastoma-binding protein 3; retinoblastoma-associated protein 1; E2F-1; RBAP1
Cat.#:E2F1-3002HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human E2F1 Protein, GST-tagged
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Cat.#:E2F1-1031HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human E2F1, His-tagged
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Cat.#:E2F1-12245HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E2F1, GST-tagged
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Cat.#:E2F1-238HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human E2F1, MYC/DDK-tagged
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Cat.#:E2F1-26458THTag:
Source (Host):Species:Human
Product nameRecombinant Human E2F1
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Cat.#:E2F1-8451HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human E2F1, His-tagged
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Cat.#:E2F1-6772CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken E2F1
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Cat.#:E2F1-6743HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human E2F1 293 Cell Lysate
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Involved Pathway

E2F1 involved in several pathways and played different roles in them. We selected most pathways E2F1 participated on our site, such as Activation of BH3-only proteins, Activation of NOXA and translocation to mitochondria, Activation of PUMA and translocation to mitochondria, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of BH3-only proteins
CDK5RAP2; BCL2L11; E2F1; YWHAQ; DYNLL2; AKT3
Activation of NOXA and translocation to mitochondria
E2F1
Activation of PUMA and translocation to mitochondria
E2F1
Adipogenesis
GADD45A; AHR; GDF10; CEBPA; MIXL1; NDN; GATA2A; E2F4; CFD; DDIT3
Apoptosis
TICAM1; NTRK1; PPP3CC; HIST1H1C; IRAK4; BOK; NMT1; Casp3; Fasl; BCL2
Assembly of the pre-replicative complex
GMNN; E2F1; MCM8; E2F2; CDT1; E2F3
Association of licensing factors with the pre-replicative complex
GMNN; E2F3; E2F2; CDT1; E2F1
Bladder cancer
TRP53; CDH1; FGFR3; RB1; MAPK3; TP53; HBEGF; RASSF1; CCND1; DAPK1

Protein Function

E2F1 has several biochemical functions, for example, DNA binding, core promoter binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F1 itself. We selected most functions E2F1 had, and list some proteins which have the same functions with E2F1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF367; SOX8; ZNF490; THAP6; POU5F1; FOSB; RNF11; CSDE1; GATA5; CERS5
Function core promoter binding
Related Protein AGO2; E2F2; HMGA2; KLF4; ELK1; NOTCH1; CLOCK; RBMX; DHX36; SFPQ
Function protein binding
Related Protein FBXO44; KRTAP19-5; TAL1; PPP1R15A; RBMX; TRAF3; TRAF3IP2; RCAN3; C10orf119; CST9L
Function protein kinase binding
Related Protein GYS1; KCNQ3; CAV1; LATS1; CDK5RAP1; RHOD; SV2A; MEF2A; FGF19; C10orf46
Function sequence-specific DNA binding
Related Protein RXRAA; SIX1B; MAFBA; HMX3; ZSCAN16; LHX1B; NKX1-2; LBX1B; HOXB2A; ZKSCAN4
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZKSCAN1; DMRTC2; ZNF471; GTF2I; TBX10; NCOR1; TULP4; NEUROG1; MEOX2; CREBZF
Function transcription factor binding
Related Protein APBB2; DAXX; FIGLA; ADD1; RBL1; TRIB1; POU5F1; TBL1X; PAXBP1; PARP1

Interacting Protein

E2F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F1.
RB1

E2F1 Related Articles

Wu, M; Zhou, JL; et al. E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression. CARDIOVASCULAR RESEARCH 104:412-422(2014).
Jiang, DF; Aguiar, RCT; et al. MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-beta 1/SMAD5 signaling module. BLOOD 123:86-93(2014).