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EDNRA

  • Official Full Name

    endothelin receptor type A

  • Overview

    This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms

    EDNRA; endothelin receptor type A; ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR; endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EDNRA-764H Active Recombinant Human EDNRA Full Length Transmembrane protein(VLPs) HEK293 N/A Asp 21 - Asn 427
Human EDNRA-3058H Recombinant Human EDNRA Protein, GST-tagged Wheat Germ GST
Human EDNRA-28562TH Recombinant Human EDNRA Wheat Germ N/A 63 amino acids
Human EDNRA-6718HCL Recombinant Human EDNRA 293 Cell Lysate HEK293 N/A
Human EDNRA-5392H Recombinant Human EDNRA protein, His-tagged Yeast His 21-80aa
Human EDNRA-2371H Recombinant Human EDNRA Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 21–427aa
Human EDNRA-6775HF Recombinant Full Length Human EDNRA Protein In Vitro Cell Free System was amino acids
Human EDNRA-22H Recombinant Human EDNRA Protein Wheat Germ N/A
Human EDNRA-1405H Recombinant Human EDNRA Protein, His-tagged E.coli N-His Asp21-Lys80
Human EDNRA-4202HF Recombinant Full Length Human EDNRA Protein, GST-tagged In Vitro Cell Free System GST 427 amino acids
Mouse EDNRA-4994M Recombinant Mouse EDNRA Protein Mammalian Cell His
Mouse EDNRA-2641M Recombinant Mouse EDNRA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EDNRA-2641M-B Recombinant Mouse EDNRA Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL2534BF Recombinant Full Length Bovine Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system His Full Length (21-427)
Canis lupus familiaris (Dog) (Canis familiaris) RFL7029CF Recombinant Full Length Dog Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system His Full Length (21-426)
Mus musculus (Mouse) RFL27599MF Recombinant Full Length Mouse Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system His Full Length (21-427)
Ovis aries (Sheep) RFL7142OF Recombinant Full Length Sheep Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system His Full Length (21-427)
Rattus norvegicus (Rat) RFL24996RF Recombinant Full Length Rat Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system His Full Length (21-426)
Rhesus Macaque EDNRA-1380R Recombinant Rhesus monkey EDNRA Protein, His-tagged Mammalian Cell His
Rhesus Macaque EDNRA-1205R-B Recombinant Rhesus Macaque EDNRA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EDNRA-1205R Recombinant Rhesus Macaque EDNRA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL6245SF Recombinant Full Length Pig Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system His Full Length (21-427)
Chicken EDNRA-5695C Recombinant Chicken EDNRA Mammalian Cell His
Kit-0914 CYP2J2 Cyan Screening Kit N/A
Kit-1229 EDNRA CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EDNRA Related Gene Family
  • EDNRA Related Research Area

EDNRA involved in several pathways and played different roles in them. We selected most pathways EDNRA participated on our site, such as Calcium signaling pathway, Class A/1 (Rhodopsin-like receptors), EGFR-dependent Endothelin signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDNRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPPP3CCA;SLC25A31;GNAQ;HTR5A;CACNA1D;ADRB2A;PLCG2;ITPKB;PLCG1
Class A/1 (Rhodopsin-like receptors)LPAR1;HEBP1;GPR55A;ZFPM2B;GPR55;OPN1LW2;PROK1;OPN1MW2;GPR132B
EGFR-dependent Endothelin signaling eventsEDN1;EDNRA
EndothelinCNN1;CALCRL;MYL1;CALCA;EDNRA;EDNRB;EDN1;RAMP1;ECE1
EndothelinsEDN2;EDN1;CYSLTR1;COL1A2;EDNRA;EDN3;EDNRB;COL3A1
G alpha (q) signalling eventsPROK1;CHRM1;ABHD6B;CYSLTR1;PRKCHB;AGTR1;UTS2;QRFP;CHRM3
GPCR downstream signalingABHD6B;OBSCN;OXGR1A.2;ADORA2A;PENKB;APLNR;ANXA1B;UTS2D;CCL27
GPCR ligand bindingGPR4;PNOC;NPFF;EMR1;GPRC6A;GPR37L1;OPN4A;S1PR3;RGR

EDNRA has several biochemical functions, for example, endothelin receptor activity, phosphatidylinositol phospholipase C activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDNRA itself. We selected most functions EDNRA had, and list some proteins which have the same functions with EDNRA. You can find most of the proteins on our site.

Function Related Protein
endothelin receptor activityEDNRBA;EDNRB;EDNRAA;EDNRAB;EDNRA
phosphatidylinositol phospholipase C activityPLCE1;PLCL1;CCR5;PLCD4;PLCL2;PLCB1;PLCD3A;PLCB4;CCL5
protein bindingCCL7;EIF1AD;UNC13A;MYLK;NAE1;BCL2L11;NKG7;AGR2;ZNF423

EDNRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDNRA here. Most of them are supplied by our site. Hope this information will be useful for your research of EDNRA.

EDN1

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