eef1e1
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  • Official Full Name
  • eukaryotic translation elongation factor 1 epsilon 1
  • Background
  • This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2.
  • Synonyms
  • EEF1E1; eukaryotic translation elongation factor 1 epsilon 1; P18; eukaryotic translation elongation factor 1 epsilon-1; AIMP3; aminoacyl tRNA synthetase complex interacting multifunctional protein 3; AIMP 3; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; ARS interacting multifunctional protein 3; Cyclin dependent kinase 6 inhibitor; Elongation factor p18; Homolog of rat elongation factor p18; MCA3_HUMAN; Multisynthase complex auxiliary component p18; Multisynthetase complex auxiliary component p18; p18 component of aminoacyl tRNA synthetase complex; p18 INK4c; p18 NK6; ARS-interacting multifunctional protein 3; p18 component of aminoacyl-tRNA synthetase complex
Cat.#:EEF1E1-3073HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EEF1E1 Protein, GST-tagged
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Cat.#:EEF1E1-12292HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EEF1E1, GST-tagged
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Cat.#:EEF1E1-131HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EEF1E1, His tagged
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Cat.#:EEF1E1-27130THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EEF1E1, His-tagged
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Cat.#:EEF1E1-3510HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EEF1E1 protein, His-tagged
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Cat.#:Eef1e1-1395MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Eef1e1 protein, His & T7-tagged
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Cat.#:EEF1E1-5002MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EEF1E1 Protein
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Cat.#:EEF1E1-1384RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EEF1E1 Protein, His-tagged
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Cat.#:EEF1E1-6713HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EEF1E1 293 Cell Lysate
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Involved Pathway

EEF1E1 involved in several pathways and played different roles in them. We selected most pathways EEF1E1 participated on our site, such as Cytosolic tRNA aminoacylation, Gene Expression, tRNA Aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EEF1E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytosolic tRNA aminoacylation
FARSB; AIMP2; DARS; AARS; MADD; AIMP1; KARS; EEF1E1
Gene Expression
TSEN15; ELAC2; MED31; TAF1D; BRF1; TRMT112; ZNF202; ZNF560; ZNF561; ZNF436
tRNA Aminoacylation
MADD; AARS; FARS2; FARSB; WARS2; DARS; AIMP1; EEF1E1; AIMP2; KARS

Protein Function

EEF1E1 has several biochemical functions, for example, glutathione transferase activity, protein binding, translation elongation factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EEF1E1 itself. We selected most functions EEF1E1 had, and list some proteins which have the same functions with EEF1E1. You can find most of the proteins on our site.
Function
Related Protein
Function glutathione transferase activity
Related Protein GSTM5; GSTM4; GSTO2; GSTT1; GSTA; GSTAL; GSTZ1; GSTM2; GSTT1B; GSTK1
Function protein binding
Related Protein SLC5A1; ACTN1; CDC25A; FAM124B; GSTM4; TAE1; STARD3; MAPK7; SLC39A7; SOX14
Function translation elongation factor activity
Related Protein EEF1A1A; EEF1B2; TSFM; TUFM; EEF2B; ABTB1; EFTUD1; EEF1A1L2; EEF1A1; EIF5A

Interacting Protein

EEF1E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EEF1E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EEF1E1.
NAT9; gag; CALCOCO2; EIF1B; ARF6; Dlgap4; ssrna_ug

EEF1E1 Related Articles

Kaiser, A; et al. Translational control of eIF5A in various diseases. AMINO ACIDS 42:679-684(2012).
Park, JH; Dias, CAO; et al. Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes. PROTEIN ENGINEERING DESIGN & SELECTION 24:301-309(2011).