efna5
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  • Official Full Name
  • ephrin-A5
  • Background
  • Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
  • Synonyms
  • EFNA5; ephrin-A5; EPLG7; AF1; LERK7; AL-1; LERK-7; eph-related receptor tyrosine kinase ligand 7; EFL5; RAGS; GLC1M
Cat.#:EFNA5-470RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat EFNA5 Protein (21-203 aa), His-tagged
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Cat.#:EFNA5-3101HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EFNA5 Protein, GST-tagged
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Cat.#:EFNA5-1133HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EFNA5 protein, His & T7-tagged
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Cat.#:EFNA5-28471THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EFNA5
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Cat.#:EFNA5-700HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNA5, His tagged
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Cat.#:EFNA5-79HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNA5, Fc tagged
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Cat.#:Efna5-4059MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efna5, Fc tagged
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Cat.#:Efna5-4060MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Efna5, His tagged
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Cat.#:Efna5-880MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Efna5 Protein, Fc Chimera
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Cat.#:Efna5-1574RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Efna5 protein, Fc-tagged
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Cat.#:Efna5-1620RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Efna5 protein, His-tagged
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Cat.#:EFNA5-2025RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EFNA5 Protein
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Cat.#:EFNA5-1430CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EFNA5 protein, His-tagged
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Cat.#:EFNA5-1431CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EFNA5 protein, Fc-tagged
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Cat.#:EFNA5-1393RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EFNA5 Protein, His-tagged
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Cat.#:EFNA5-993CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine EFNA5 protein, Fc-tagged
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Cat.#:EFNA5-6739CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EFNA5
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Cat.#:EFNA5-1611HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Ephrin-A5
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Cat.#:EFNA5-2734HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human EFNA5 cell lysate
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Cat.#:EFNA5-2156MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EFNA5 cell lysate
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Cat.#:EFNA5-1574RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat EFNA5 cell lysate
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Cat.#:EFNA5-1430CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EFNA5 cell lysate
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Cat.#:EFNA5-993CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine EFNA5 cell lysate
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Involved Pathway

EFNA5 involved in several pathways and played different roles in them. We selected most pathways EFNA5 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
SLIT3; RAC3; ROBO2; SEMA3A; EPHA5; PTK2; NCAN; NADL1.1; ST8SIA2; SEMA3C
Developmental Biology
ITSN1; SEMA3AB; SCN2A; GFRA2; FRS2A; NRTN; CNTN1; EFNB2; SPTA1; LGI1A
EPH-Ephrin signaling
ARHGEF28; AP2A2; SHB; EFNB3; EPHA2; EFNB3B; ARPC3; ITSN1; DNM1; MYL9
EPH-ephrin mediated repulsion of cells
EFNA4; EFNA1B; EFNA2; EPHA2; EPHB3A; EFNA5; AP2A2; AP2S1; EPHA4A; EFNA3
EPHA forward signaling
CRKL; EFNA2; EFNA3; EPHA2; EFNA1; BLK; EFNA5; ARHGEF15
EPHA-mediated growth cone collapse
EFNA2A; EFNA1B; EPHA2; EPHA2A; EFNA2; EFNA3B; MYL12B; EFNA4; EPHA10; SHB
EPHB forward signaling
EFNB2; EFNB1; EFNB3; GRB7; ITSN1; EFNA5
Ephrin A reverse signaling
EFNA5

Protein Function

EFNA5 has several biochemical functions, for example, chemorepellent activity, ephrin receptor binding, neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNA5 itself. We selected most functions EFNA5 had, and list some proteins which have the same functions with EFNA5. You can find most of the proteins on our site.
Function
Related Protein
Function chemorepellent activity
Related Protein SLIT2; SEMA3D; SEMA6B; FLRT2; NRG1; SEMA3H; SEMA6E; SEMA6DL; SEMA3GB; SEMA3C
Function ephrin receptor binding
Related Protein PTPN1; EFNA5; CBL; GRB2; EFNB3; EFNA2A; Anks1; SDCBP; EFNA1; CHN1
Function neurotrophin TRKA receptor binding
Related Protein GRB2; EFNA5; FRS2; PLCG1; SHC1; NGFR; PIK3R1
Function neurotrophin TRKB receptor binding
Related Protein EFNA5; BDNF
Function neurotrophin TRKC receptor binding
Related Protein EFNA5
Function transmembrane receptor protein tyrosine kinase activator activity
Related Protein ANGPT4; EFNA5; GREM1; NRG1; NRG3; EGF

Interacting Protein

EFNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNA5.
EPHA7; ABL1

EFNA5 Related Articles

Ramanan, VK; Risacher, SL; et al. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. MOLECULAR PSYCHIATRY 19:351-357(2014).
Lin, QH; Zhou, N; et al. Mutational Screening of EFNA5 in Chinese Age-Related Cataract Patients. OPHTHALMIC RESEARCH 52:124-129(2014).