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EFNA5

  • Official Full Name

    ephrin-A5

  • Overview

    Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
  • Synonyms

    EFNA5; ephrin-A5; EPLG7; AF1; LERK7; AL-1; LERK-7; eph-related receptor tyrosine kinase ligand 7; EFL5; RAGS; GLC1M;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • hFc
  • His
  • GST
  • hIgG
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EFNA5-700H Active Recombinant Human EFNA5, His tagged HEK293 His Met 1-Asn 203
Human EFNA5-79H Recombinant Human EFNA5 protein, hFc-tagged HEK293 hFc Met1-Asn203
Human EFNA5-1133H Recombinant Human EFNA5 protein, His & T7-tagged E.coli His/T7 Gln21~Asn203 (Accession # P52803)
Human EFNA5-1611H Recombinant Human Ephrin-A5 Mammalian cells N/A
Human EFNA5-28471TH Recombinant Human EFNA5 Wheat Germ N/A 90 amino acids
Human EFNA5-3101H Recombinant Human EFNA5 Protein, GST-tagged Wheat Germ GST
Human EFNA5-2734HCL Recombinant Human EFNA5 cell lysate Human Cell N/A
Human EFNA5-4397H-B Recombinant Human EFNA5 Protein Pre-coupled Magnetic Beads HEK293
Human EFNA5-4397H Recombinant Human EFNA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EFNA5-16H Recombinant Human EFNA5 Protein, hIgG/His-tagged Insect Cell hIgG/His 21-203
Human EFNA5-2033H Recombinant Human EFNA5 Protein (Gln21-Asn203), N-His tagged E.coli N-His Gln21-Asn203
Human EFNA5-2692H Active Recombinant Human EFNA5 protein, hFc&His-tagged HEK293 hFc&His Gln21-Asn203
Human EFNA5-3006H Recombinant Human EFNA5 Protein (Gln21-Asn203), C-Fc tagged Mammalian cells C-Fc Gln21-Asn203
Mouse Efna5-880M Active Recombinant Mouse Efna5 Protein, Fc Chimera Mammalian cells Fc
Mouse Efna5-4060M Active Recombinant Mouse Efna5 protein, His-tagged HEK293 His Met1-Asn203
Mouse Efna5-4059M Active Recombinant Mouse Efna5 protein, hFc-tagged HEK293 hFc Met1-Asn203
Mouse EFNA5-2156MCL Recombinant Mouse EFNA5 cell lysate Human Cell N/A
Mouse Efna5-29M Recombinant Mouse Efna5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Efna5-5645M Recombinant Mouse Efna5 Protein (Gln21-Gln206), C-His tagged Mammalian cells C-His Gln21-Gln206
Mouse Efna5-29M-B Recombinant Mouse Efna5 Protein Pre-coupled Magnetic Beads HEK293
Rat Efna5-1574R Active Recombinant Rat Efna5 protein, Fc-tagged HEK293 Fc Met 1-Glu 202
Rat Efna5-1620R Active Recombinant Rat Efna5 protein, His-tagged HEK293 His Met 1-Glu 202
Rat EFNA5-2025R Recombinant Rat EFNA5 Protein Mammalian Cell His
Rat EFNA5-1574RCL Recombinant Rat EFNA5 cell lysate Human Cell N/A
Rat Efna5-5393R Recombinant Rat Efna5 protein, His-tagged Yeast His 21-203aa
Rat EFNA5-1682R-B Recombinant Rat EFNA5 Protein Pre-coupled Magnetic Beads HEK293
Rat EFNA5-470R Recombinant Rat EFNA5 Protein (21-203 aa), His-tagged E.coli His 21-203 aa
Rat EFNA5-1682R Recombinant Rat EFNA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine EFNA5-993C Active Recombinant Canine EFNA5 protein, Fc-tagged HEK293 Fc Met1-Asn203
Canine EFNA5-993CCL Recombinant Canine EFNA5 cell lysate Human Cell N/A
Cynomolgus Monkey EFNA5-1430C Active Recombinant Cynomolgus EFNA5 protein, His-tagged HEK293 His Met1-Asn203
Cynomolgus Monkey EFNA5-1431C Active Recombinant Cynomolgus EFNA5 protein, Fc-tagged HEK293 Fc Met1-Asn203
Cynomolgus Monkey EFNA5-1430CCL Recombinant Cynomolgus EFNA5 cell lysate Human Cell N/A
Rhesus EFNA5-1285R Acitve Recombinant Rhesus EFNA5 protein(Met1-Asn203), hFc-tagged HEK293 C-hFc Met1-Asn203
Rhesus EFNA5-130R Active Recombinant Rhesus EFNA5 protein, hFc-tagged HEK293 hFc Met 1-Asn 203
Rhesus EFNA5-1093R Active Recombinant Rhesus EFNA5 protein, His-tagged HEK293 His Met1-Asn203
Rhesus Macaque EFNA5-1393R Recombinant Rhesus monkey EFNA5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EFNA5-1218R Recombinant Rhesus Macaque EFNA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EFNA5-1218R-B Recombinant Rhesus Macaque EFNA5 Protein Pre-coupled Magnetic Beads HEK293
Chicken EFNA5-6739C Recombinant Chicken EFNA5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EFNA5 Related Articles
  • EFNA5 Related Research Area

EFNA5 involved in several pathways and played different roles in them. We selected most pathways EFNA5 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceGFRA2;GFRA1;SHB;MYL12A;DPYSL5A;NTN1;PPP3CC;SCN3A;HFE2
Developmental BiologyKCNQ2;CTNNA2;SCN3A;LIN28A;NRG2A;RHOC;TDGF1;DPYSL5B;MED20
EPH-Ephrin signalingCFL1;AP2B1;EFNB1;MYL12B;ACTR3;EPHB4B;ARPC3;EFNA2;CLTC
EPH-ephrin mediated repulsion of cellsEPHA4A;EFNA2;EFNA3B;EPHB4A;EFNB3;AP2B1;EFNB2;EFNA4;EFNA1A
EPHA forward signalingEFNA1;ARHGEF15;EFNA3;EPHA2;EFNA2;CRKL;BLK;EFNA5
EPHA-mediated growth cone collapseEFNA1B;EPHA10;EFNA4;EPHA4A;EFNA5;MYL9;EFNA3B;SHB;EPHA2A
EPHB forward signalingITSN1;EFNB2;EFNA5;GRB7;EFNB3;EFNB1
Ephrin A reverse signaling

EFNA5 has several biochemical functions, for example, chemorepellent activity, ephrin receptor binding, neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNA5 itself. We selected most functions EFNA5 had, and list some proteins which have the same functions with EFNA5. You can find most of the proteins on our site.

Function Related Protein
chemorepellent activitySEMA6D;SEMA3A;SEMA4A;EPHA7;SEMA3G;SEMA6E;SEMA4BA;NRG1;SEMA3GA
ephrin receptor bindingPIK3CG;EFNB3;EFNA4;EPHA7;CDK5R1;EFNA5B;PTPN1;CHN1;EFNA2A
neurotrophin TRKA receptor bindingNGFR;SHC1;FRS2;PIK3R1;EFNA5;GRB2;PLCG1
neurotrophin TRKB receptor bindingEFNA5;BDNF
neurotrophin TRKC receptor binding
transmembrane receptor protein tyrosine kinase activator activityNRG3;GREM1;NRG1;ANGPT4;EGF;EFNA5

EFNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNA5.

EPHA7; ABL1

Ramanan, VK; Risacher, SL; et al. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. MOLECULAR PSYCHIATRY 19:351-357(2014).
Lin, QH; Zhou, N; et al. Mutational Screening of EFNA5 in Chinese Age-Related Cataract Patients. OPHTHALMIC RESEARCH 52:124-129(2014).
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