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EIF2AK3

  • Official Full Name

    eukaryotic translation initiation factor 2-alpha kinase 3

  • Overview

    PERK (PKR-like ER kinase) is a single-pass type I ER membrane protein with a stress-sensing luminal domain connected by a transmembrane segment to a cytoplasmic-kinase domain.
  • Synonyms

    EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3; PEK; PERK; hsPEK; pancreatic EIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase; eukaryotic translation initiation factor 2 alpha kinase 3; WRS; DKFZp781H1925;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF2AK3-30644TH Recombinant Human EIF2AK3 E.coli N/A 554 amino acids
Human EIF2AK3-3150H Active Recombinant Human EIF2AK3 Protein, GST-tagged E.coli GST
Human EIF2AK3-337H Recombinant Human EIF2AK3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EIF2AK3-1010H Recombinant Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, GST-tagged E.coli GST
Human EIF2AK3-3151H Recombinant Human EIF2AK3 Protein, GST-tagged Wheat Germ GST
Human EIF2AK3-6673HCL Recombinant Human EIF2AK3 293 Cell Lysate HEK293 N/A
Human EIF2AK3-186HFL Active Recombinant Full Length Human EIF2AK3 Protein, C-Flag-tagged Mammalian cells Flag
Human EIF2AK3-2744H Recombinant Human EIF2AK3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF2AK3-819H Recombinant Human EIF2AK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EIF2AK3-1413H Recombinant Human EIF2AK3 Protein, His-tagged E.coli N-His Phe593-Phe1077
Human EIF2AK3-819H-B Recombinant Human EIF2AK3 Protein Pre-coupled Magnetic Beads HEK293
Human EIF2AK3-1020H Recombinant Human EIF2AK3 Protein, His-tagged E.coli His
Mouse Eif2ak3-1392M Recombinant Mouse Eif2ak3 protein, His & T7-tagged E.coli His/T7 Met973~Asn1114 (Accession # Q9Z2B5)
Mouse Eif2ak3-2772M Recombinant Mouse Eif2ak3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat EIF2AK3-2045R Recombinant Rat EIF2AK3 Protein Mammalian Cell His
Rat EIF2AK3-1702R Recombinant Rat EIF2AK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF2AK3-1702R-B Recombinant Rat EIF2AK3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

EIF2AK3 involved in several pathways and played different roles in them. We selected most pathways EIF2AK3 participated on our site, such as Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumGANAB;HSPA1A;UBQLN4;HSPA1B;RAD23A;CRYAA;MAP3K5;ATF4;DNAJB1A
Non-alcoholic fatty liver disease (NAFLD)PRKAA2;CASP8;LEPR;SDHD;XBP1;UQCRFS1;ADIPOR1;COX6A2;NDUFA10
Alzheimers diseaseADAM10;COX4I1;ITPR1;CAPN1;COX7B2;UQCRC2;TNFRSF1A;CALM1;UQCRH
Hepatitis CCXCL8;CLDN7;BAD;CLDN17;IFNA4;PPP2CA;RAF1;MAVS;CLDN1
MeaslesIFNGR2;MAVS;IL1B;IL6;DDX58;IL1A;OAS1;TRAF6;IRAK4
Influenza AEIF2AK4;CPSF4;IFNA2;AGFG1;HSPA2;EIF2AK1;TNFRSF10A;PIK3CB;HLA-DRB5
Herpes simplex infectionMAVS;C1QBP;PER1A;PER1;PKZ;TAF6L;GLTSCR2;IFNA4;PTPN11A
Epstein-Barr virus infectionTRAF5;MAP3K7;FGR;POLR3C;YWHAH;SFPI1;HSPB2;PRKACB;GTF2B

EIF2AK3 has several biochemical functions, for example, ATP binding, Hsp90 protein binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK3 itself. We selected most functions EIF2AK3 had, and list some proteins which have the same functions with EIF2AK3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP2B2;DGKAA;CSNK1DB;EPB42;EIF4A1B;P2RX5;ATRX;DDX17;ACTR2
Hsp90 protein bindingERN1;UNC45B;ARNTL;HIF1A;UNC45A;USP19;GBP1;ERBB2;EIF2AK3
enzyme bindingHNRNPUL1;CUTA;RXRA;C2orf56;CYP3A4;NOTCH3;TNKS2;N4BP2L2;FAM84B
eukaryotic translation initiation factor 2alpha kinase activityALPK2;EIF2AK2;EIF2AK1;EIF2AK3;EIF2AK4
identical protein bindingSNX8;CAD;FHIT;NDC80;IMPA1;HSD17B10;CBX3;LUC7L;PACSIN2
protein bindingTCEB2;PIK3CG;PIP5K1B;PIN1;DYNLL1;LTF;C12orf50;STBD1;RXRA
protein homodimerization activityATPIF1;NKX2;RBM11;PLDN;MTUS2;QPRT;GPD1B;IL12B;Il6ra
protein kinase activityPLK5;PRKACBB;CAMK2B1;KDRL;CDC42BPB;GUCY2F;CSF1RA;CAMK2D2;CAMKK1B
protein phosphatase bindingANAPC4;RPA2;PIK3R2;MAP3K5;TRP53;RPA3;ANAPC5;STAT3;PIK3R1
protein serine/threonine kinase activityMAPK14;TSSK4;PRKD2;TNIK;HUNK;CAMK2B1;LIMK1;PIK3R4;ACVRL1

EIF2AK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK3.

HSPA5; HSP90B1; aroE; BCL6

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