EIF2AK3 Protein, eukaryotic translation initiation factor 2-alpha kinase 3


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Official Full Name eukaryotic translation initiation factor 2-alpha kinase 3
Background PERK (PKR-like ER kinase) is a single-pass type I ER membrane protein with a stress-sensing luminal domain connected by a transmembrane segment to a cytoplasmic-kinase domain.
Synonyms EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3; PEK; PERK; hsPEK; pancreatic EIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase; eukaryotic translation initiation factor 2 alpha kinase 3; WRS; DKFZp781H1925
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF2AK3-1010H Recombinant Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, GST-tagged E.coli GST
    Human EIF2AK3-1020H Recombinant Human EIF2AK3 Protein, His-tagged E.coli His
    Human EIF2AK3-30644TH Recombinant Human EIF2AK3 E.coli N/A
    Human EIF2AK3-3150H Recombinant Human EIF2AK3 Protein, GST-tagged E.coli GST
    Human EIF2AK3-3151H Recombinant Human EIF2AK3 Protein, GST-tagged Wheat Germ GST
    Human EIF2AK3-337H Recombinant Human EIF2AK3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EIF2AK3-6673HCL Recombinant Human EIF2AK3 293 Cell Lysate HEK293 N/A
    Mouse Eif2ak3-1392M Recombinant Mouse Eif2ak3 protein, His & T7-tagged E.coli His/T7
    Rat EIF2AK3-2045R Recombinant Rat EIF2AK3 Protein Mammalian Cell His

    EIF2AK3 involved in several pathways and played different roles in them. We selected most pathways EIF2AK3 participated on our site, such as Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum HSP90B1; CALRL2; SEC61A1; UBE2D2; SELS; HSP70; SEC24C; MBTPS2; NFE2L2; CRYAA
    Non-alcoholic fatty liver disease (NAFLD) AKT2; ITCH; NDUFA9; IRS1; TRAF2; ATF4; LEPR; UQCRC1; ADIPOR2; NDUFB3
    Alzheimers disease APH1B; NDUFB5; IDE; NDUFA1; NDUFB2; NDUFS3; GRIN2D; ITPR3; UQCR10; NDUFS2
    Measles IRAK1; PIK3R1; HSPA1B; TBK1; TNFRSF10B; TYK2; NFKB1; CD209A; FYN; CD46
    Herpes simplex infection IFNA5; BLA; TAF9B; SRSF7A; TRAF2; CASP3B; Hc; TTC6; IRF7; SRSF2
    Epstein-Barr virus infection MAP3K14; GTF2E2; MAP2K3; PLCG1; PRKACG; EIF2AK1; MAPK10; HSPA1L; HSPA1A; POLR2L

    EIF2AK3 has several biochemical functions, for example, ATP binding, Hsp90 protein binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK3 itself. We selected most functions EIF2AK3 had, and list some proteins which have the same functions with EIF2AK3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DHX33; NTRK2; MSH5; TTL; MCM9; MYH11A; DDX10; ACOT12; HARS2; TBK1
    Hsp90 protein binding PPID; UNC45A; EIF2AK3; STUB1; CHORDC1; PPEF2; RPS3; TELO2; FKBP6; HDAC6
    enzyme binding DIS3L; NPM2; RAD9A; NOTCH3; BCR; YES1; YWHAB; PRTN3; HIST1H2AI; CBX3
    eukaryotic translation initiation factor 2alpha kinase activity EIF2AK3; ALPK2; EIF2AK2; EIF2AK4; EIF2AK1
    identical protein binding GOT2; TTC32; CIDEB; SEPT7; PAICS; DES; ADORA2A; PLDN; CEP170L; STXBP1
    protein binding KIAA1191; SEMA4A; MOBKL1A; NKX3; CELSR1; HIST1H4B; ACCS; TRIM39; SF3A3; FGFR3
    protein homodimerization activity ADSSL1; APOBEC3G; ADH1; ATPIF1; TENM3; SPPL3; TRIM37; RAB11FIP4A; FLRT3; DGCR8
    protein kinase activity SIK2A; PLK5; TNNI3K; ADRBK2; NLK1; CAD; EEF2K; MAPK8B; CDK14; EK1
    protein phosphatase binding KCNN4; TRP53; STAT6; VRK3; PIK3R1; CDH2; VCP; SHOC2; ITPR1; ERBB2
    protein serine/threonine kinase activity NEK12; MAPK12B; ACVR2B; STK35L; RIPK2; UHMK1; CSNK1G1; HIPK3; DCAMKL2; AURKB

    EIF2AK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK3.

    HSPA5; HSP90B1; aroE; BCL6

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