Description : |
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
125.26 kDa |
AA Sequence : |
MERAISPGLLVRALLLLLLLLGLAA RTVAAGRARGLPAPTAEAAFGLGAA AAPTSATRVPAAGAVAAAEVTVEDA EALPAAAGEQEPRGPEPDDETELRP RGRSLVIISTLDGRIAALDPENHGK KQWDLDVGSGSLVSSSLSKPEVFGN KMIIPSLDGALFQWDRDRESMETVP FTVESLLESSYKFGDDVVLVGGKSL TTYGLSAYSGKVRYICSALGCRQWD SDEMEQEEDILLLQRTQKTVRAVGP RSGNEKWNFSVGHFELRYIPDMETR AGFIESTFKPNENTEESKIISDVEE QEAAIMDIVIKVSVADWKVMAFSKK GGHLEWEYQFCTPIASAWLLKDGKV IPISLFDDTSYTSNDDVLEDEEDIV EAARGATENSVYLGMYRGQLYLQSS VRISEKFPSSPKALESVTNENAIIP LPTIKWKPLIHSPSRTPVLVGSDEF DKCLSNDKFSHEEYSNGALSILQYP YDNGYYLPYYKRERNKRSTQITVRF LDNPHYNKNIRKKDPVLLLHWWKEI VATILFCIIATTFIVRRLFHPHPHR QRKESETQCQTENKYDSVSGEANDS SWNDIKNSGYISRYLTDFEPIQCLG RGGFGVVFEAKNKVDDCNYAIKRIR LPNRELAREKVMREVKALAKLEHPG IVRYFNAWLEAPPEKWQEKMDEIWL KDESTDWPLSSPSPMDAPSVKIRRM DPFSTKEHIEIIAPSPQRSRSFSVG ISCDQTSSSESQFSPLEFSGMDHED ISESVDAAYNLQDSCLTDCDVEDGT MDGNDEGHSFELCPSEASPYVRSRE RTSSSIVFEDSGCDNASSKEEPKTN RLHIGNHCANKLTAFKPTSSKSSSE ATLSISPPRPTTLSLDLTKNTTEKL QPSSPKVYLYIQMQLCRKENLKDWM NGRCTIEERERSVCLHIFLQIAEAV EFLHSKGLMHRDLKPSNIFFTMDDV VKVGDFGLVTAMDQDEEEQTVLTPM PAYARHTGQVGTKLYMSPEQIHGNS YSHKVDIFSLGLILFELLYPFSTQM ERVRTLTDVRNLKFPPLFTQKYPCE YVMVQDMLSPSPMERPEAINIIENA VFEDLDFPGKTVLRQRSRSLSSSGT KHSRQSNNSHSPLPSNTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |